Ammonium ionic liquids as green solvents for drugs 

Detalhes bibliográficos
Autor(a) principal: Melo, Catarina I.
Data de Publicação: 2013
Outros Autores: Lukasik, Rafal M., Ponte, Manuel Nunes, Bogel-Lukasik, Ewa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.9/2326
Resumo: A high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and corresponding enthalpies for both isoniazid and pyrazinecarboxamide as well as for three ammonium salts were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in analysed ILs was found to be higher than that of pyrazinecarboxamide. Considering ammonium salts examined in this work, didecyldimethylammonium nitrate is the best solvent for both antibiotics. The solid–liquid phase equilibria were described using six different correlation equations which revealed a relatively good description with an acceptable standard deviation temperature range.
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spelling Ammonium ionic liquids as green solvents for drugs AntibioticTuberculosisIonic liquidsSolubilityPhase equilibriaThermochemical propertiesA high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and corresponding enthalpies for both isoniazid and pyrazinecarboxamide as well as for three ammonium salts were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in analysed ILs was found to be higher than that of pyrazinecarboxamide. Considering ammonium salts examined in this work, didecyldimethylammonium nitrate is the best solvent for both antibiotics. The solid–liquid phase equilibria were described using six different correlation equations which revealed a relatively good description with an acceptable standard deviation temperature range.ElsevierRepositório do LNEGMelo, Catarina I.Lukasik, Rafal M.Ponte, Manuel NunesBogel-Lukasik, Ewa2014-03-19T15:11:53Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.9/2326engMelo, Catarina I.; Bogel-Lukasik, R.; Ponte, Manuel N.; Bogel-Lukasik, E. Ammonium ionic liquids as green solvents for drugs. In: Fluid Phase Equilibria, 2013, Vol. 338, p. 209-2160378-3812info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-12T05:23:50Zoai:repositorio.lneg.pt:10400.9/2326Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:35:13.200951Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ammonium ionic liquids as green solvents for drugs 
title Ammonium ionic liquids as green solvents for drugs 
spellingShingle Ammonium ionic liquids as green solvents for drugs 
Melo, Catarina I.
Antibiotic
Tuberculosis
Ionic liquids
Solubility
Phase equilibria
Thermochemical properties
title_short Ammonium ionic liquids as green solvents for drugs 
title_full Ammonium ionic liquids as green solvents for drugs 
title_fullStr Ammonium ionic liquids as green solvents for drugs 
title_full_unstemmed Ammonium ionic liquids as green solvents for drugs 
title_sort Ammonium ionic liquids as green solvents for drugs 
author Melo, Catarina I.
author_facet Melo, Catarina I.
Lukasik, Rafal M.
Ponte, Manuel Nunes
Bogel-Lukasik, Ewa
author_role author
author2 Lukasik, Rafal M.
Ponte, Manuel Nunes
Bogel-Lukasik, Ewa
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do LNEG
dc.contributor.author.fl_str_mv Melo, Catarina I.
Lukasik, Rafal M.
Ponte, Manuel Nunes
Bogel-Lukasik, Ewa
dc.subject.por.fl_str_mv Antibiotic
Tuberculosis
Ionic liquids
Solubility
Phase equilibria
Thermochemical properties
topic Antibiotic
Tuberculosis
Ionic liquids
Solubility
Phase equilibria
Thermochemical properties
description A high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and corresponding enthalpies for both isoniazid and pyrazinecarboxamide as well as for three ammonium salts were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in analysed ILs was found to be higher than that of pyrazinecarboxamide. Considering ammonium salts examined in this work, didecyldimethylammonium nitrate is the best solvent for both antibiotics. The solid–liquid phase equilibria were described using six different correlation equations which revealed a relatively good description with an acceptable standard deviation temperature range.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2014-03-19T15:11:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.9/2326
url http://hdl.handle.net/10400.9/2326
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Melo, Catarina I.; Bogel-Lukasik, R.; Ponte, Manuel N.; Bogel-Lukasik, E. Ammonium ionic liquids as green solvents for drugs. In: Fluid Phase Equilibria, 2013, Vol. 338, p. 209-216
0378-3812
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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