A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents

Detalhes bibliográficos
Autor(a) principal: Forte, Andreia
Data de Publicação: 2012
Outros Autores: Melo, Catarina I., Lukasik, Rafal M., Bogel-Lukasik, Ewa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.9/1915
Resumo: The sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid–liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range.
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spelling A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solventsIsoniazidIonic liquidsSolubilitySolid–liquid equilibriumThermochemical propertiesDrugAntibioticThe sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid–liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range.ElsevierRepositório do LNEGForte, AndreiaMelo, Catarina I.Lukasik, Rafal M.Bogel-Lukasik, Ewa2013-07-11T12:07:00Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.9/1915engForte, Andreia; Melo, Catarina, I.; Bogel-Lukasik, R.; Bogel-Lukasik, E. A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents. In: Fluid Phase Equilibria, 2012, vol. 318, p. 89-950378-3812info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-26T06:44:13Zoai:repositorio.lneg.pt:10400.9/1915Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:34:42.291012Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
title A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
spellingShingle A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
Forte, Andreia
Isoniazid
Ionic liquids
Solubility
Solid–liquid equilibrium
Thermochemical properties
Drug
Antibiotic
title_short A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
title_full A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
title_fullStr A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
title_full_unstemmed A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
title_sort A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents
author Forte, Andreia
author_facet Forte, Andreia
Melo, Catarina I.
Lukasik, Rafal M.
Bogel-Lukasik, Ewa
author_role author
author2 Melo, Catarina I.
Lukasik, Rafal M.
Bogel-Lukasik, Ewa
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório do LNEG
dc.contributor.author.fl_str_mv Forte, Andreia
Melo, Catarina I.
Lukasik, Rafal M.
Bogel-Lukasik, Ewa
dc.subject.por.fl_str_mv Isoniazid
Ionic liquids
Solubility
Solid–liquid equilibrium
Thermochemical properties
Drug
Antibiotic
topic Isoniazid
Ionic liquids
Solubility
Solid–liquid equilibrium
Thermochemical properties
Drug
Antibiotic
description The sufficient solubility of isoniazid in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of isoniazid were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in bis(trifluoromethylsulfonyl)amide ionic liquids was found to be significantly lower than in the studied trifluoromethanesulfonate ionic liquid. The best solvent amongst studied for this common antibiotic against tuberculosis was discovered. The solid–liquid phase equilibria were described using the six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-07-11T12:07:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.9/1915
url http://hdl.handle.net/10400.9/1915
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Forte, Andreia; Melo, Catarina, I.; Bogel-Lukasik, R.; Bogel-Lukasik, E. A favourable solubility of isoniazid, an antitubercular antibiotic drug, in alternative solvents. In: Fluid Phase Equilibria, 2012, vol. 318, p. 89-95
0378-3812
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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