Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers
Main Author: | |
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Publication Date: | 1997 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10198/1148 |
Summary: | The objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results. |
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Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomersSimulated moving bed chromatographyEnantiomer separationComputer simulationBinaphtholThe objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results.ElsevierBiblioteca Digital do IPBPais, Luís S.Loureiro, José M.Rodrigues, Alírio2009-04-17T15:22:13Z199719971997-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/1148engengPais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (1997). Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers. Journal of Chromatography A. ISSN 0021-9673. 769:1, p.25-360021-9673J. Chromatogr. A10.1016/S0021-9673(96)01076-Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:04:28Zoai:bibliotecadigital.ipb.pt:10198/1148Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:54:42.844403Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
title |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
spellingShingle |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers Pais, Luís S. Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
title_short |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
title_full |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
title_fullStr |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
title_full_unstemmed |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
title_sort |
Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers |
author |
Pais, Luís S. |
author_facet |
Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
author_role |
author |
author2 |
Loureiro, José M. Rodrigues, Alírio |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Pais, Luís S. Loureiro, José M. Rodrigues, Alírio |
dc.subject.por.fl_str_mv |
Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
topic |
Simulated moving bed chromatography Enantiomer separation Computer simulation Binaphthol |
description |
The objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as eluent by simulated moving bed chromatography (SMB). A model for the prediction of the cyclic steady state performance of the SMB, based on the analogy with the true moving bed, is developed assuming axial dispersion flow, linear driving force approximation for intraparticle mass transfer and multicomponent adsorption equilibria. The SMB package allows the simulation of the pilot unit. The effect of several operating parameters on the SMB performance is analyzed. The performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package is an important tool for learning and training operators, allowing the choice of best operating conditions. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures using a 8-column configuration. Purities and recoveries higher than 95% in the extract and raffinate were obtained. Model and experimental results are compared and the package is also used to predict the steady state internal profiles for the SMB operation in good agreement with experimental results. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997 1997 1997-01-01T00:00:00Z 2009-04-17T15:22:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/1148 |
url |
http://hdl.handle.net/10198/1148 |
dc.language.iso.fl_str_mv |
eng eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pais, L.S.; Loureiro, J.M.; Rodrigues, A.E. (1997). Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1'-bi-2-naphthol enantiomers. Journal of Chromatography A. ISSN 0021-9673. 769:1, p.25-36 0021-9673 J. Chromatogr. A 10.1016/S0021-9673(96)01076-X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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