Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy

Detalhes bibliográficos
Autor(a) principal: Prasad, Rajendra
Data de Publicação: 2020
Outros Autores: Jain, Nishant K., Yadav, Amit S., Chauhan, Deepak S., Devrukhkar, Janhavi, Kumawat, Mukesh K., Shinde, Shweta, Gorain, Mahadeo, Thakor, Avnesh S., Kundu, Gopal C., Conde, João, Srivastava, Rohit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/99540
Resumo: This work was supported by the Department of Biotechnology, Government of India. We are grateful to the National Center for Cell Science, Pune, for in vivo studies. J.C. acknowledges ERC-2019-STG. We are thankful to Mr. Anand and Dr. Ashish Kumar (MD, medical radiologist) for fruitful discussion on tomography imaging and analysis.
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spelling Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapyBiochemistry, Genetics and Molecular Biology(all)Agricultural and Biological Sciences(all)Medicine (miscellaneous)SDG 3 - Good Health and Well-beingThis work was supported by the Department of Biotechnology, Government of India. We are grateful to the National Center for Cell Science, Pune, for in vivo studies. J.C. acknowledges ERC-2019-STG. We are thankful to Mr. Anand and Dr. Ashish Kumar (MD, medical radiologist) for fruitful discussion on tomography imaging and analysis.Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is a challenging task. Herein, we established a light mediated phototriggered strategy for enhanced tumor accumulation of nanohybrids. A multifunctional liposome based nanotheranostics loaded with gold nanoparticles (AuNPs) and emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit phototriggered chemotherapy and functionalized with folic acid targeting ligands. Encapsulated agents showed imaging bimodality for in vivo tumor diagnosis due to their high contrast and emissive nature. Targeted NFGL nanohybrids demonstrated near infrared light (NIR, 750 nm) mediated tumor reduction because of generated heat and Reactive Oxygen Species (ROS). Moreover, NFGL nanohybrids exhibited remarkable ROS scavenging ability as compared to GQDs loaded liposomes validated by antitumor study. Hence, this approach and engineered system could open new direction for targeted imaging and cancer therapy.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPrasad, RajendraJain, Nishant K.Yadav, Amit S.Chauhan, Deepak S.Devrukhkar, JanhaviKumawat, Mukesh K.Shinde, ShwetaGorain, MahadeoThakor, Avnesh S.Kundu, Gopal C.Conde, JoãoSrivastava, Rohit2020-06-17T22:48:13Z2020-12-012020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/99540eng2399-3642PURE: 18623722https://doi.org/10.1038/s42003-020-1016-zinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:46:26Zoai:run.unl.pt:10362/99540Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:39:12.393823Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
title Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
spellingShingle Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
Prasad, Rajendra
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Medicine (miscellaneous)
SDG 3 - Good Health and Well-being
title_short Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
title_full Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
title_fullStr Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
title_full_unstemmed Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
title_sort Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
author Prasad, Rajendra
author_facet Prasad, Rajendra
Jain, Nishant K.
Yadav, Amit S.
Chauhan, Deepak S.
Devrukhkar, Janhavi
Kumawat, Mukesh K.
Shinde, Shweta
Gorain, Mahadeo
Thakor, Avnesh S.
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
author_role author
author2 Jain, Nishant K.
Yadav, Amit S.
Chauhan, Deepak S.
Devrukhkar, Janhavi
Kumawat, Mukesh K.
Shinde, Shweta
Gorain, Mahadeo
Thakor, Avnesh S.
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Prasad, Rajendra
Jain, Nishant K.
Yadav, Amit S.
Chauhan, Deepak S.
Devrukhkar, Janhavi
Kumawat, Mukesh K.
Shinde, Shweta
Gorain, Mahadeo
Thakor, Avnesh S.
Kundu, Gopal C.
Conde, João
Srivastava, Rohit
dc.subject.por.fl_str_mv Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Medicine (miscellaneous)
SDG 3 - Good Health and Well-being
topic Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Medicine (miscellaneous)
SDG 3 - Good Health and Well-being
description This work was supported by the Department of Biotechnology, Government of India. We are grateful to the National Center for Cell Science, Pune, for in vivo studies. J.C. acknowledges ERC-2019-STG. We are thankful to Mr. Anand and Dr. Ashish Kumar (MD, medical radiologist) for fruitful discussion on tomography imaging and analysis.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-17T22:48:13Z
2020-12-01
2020-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/99540
url http://hdl.handle.net/10362/99540
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2399-3642
PURE: 18623722
https://doi.org/10.1038/s42003-020-1016-z
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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