Quantification of the TMS-EEG response in epilepsy

Detalhes bibliográficos
Autor(a) principal: Santos, Maria Inês Fonseca Silva
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/8502
Resumo: Dissertação para obtenção do Grau de Mestre em Engenharia Biomédica
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spelling Quantification of the TMS-EEG response in epilepsyEpilepsyQuantificationTMS-EEGPowerTopographyAmplitudeDissertação para obtenção do Grau de Mestre em Engenharia BiomédicaPurpose: The purpose of this thesis was to provide quantitative measures of the co-registration of transcranial magnetic stimulation (TMS) and electroencephalogram (EEG). The EEG is used to study changes in the neuronal activity evoked by the non-invasive technique TMS. These effects are determined mainly based on clinical judgment. Current uses in the diagnosis of epilepsy are based only on EEG, not taking into consideration the low sensitivity in the interictal period, in particular if routine recordings are used. Methods: Patient data was gathered, analyzed and compared to healthy controls. A total of ten patients and eighteen healthy subjects underwent sessions of 75 TMS pulses. The responses to the pulses were filtered and averaged. The use of topographical scalp plots of amplitude and power, and time-series analysis of power in search for late responses provide results which enable separation of epilepsy patients and healthy controls. By investigating the significance of the results it is also possible to determine, in a quantitative way how reliable the methods are for distinguishing between the two groups. Results: The definition of what is a response is critical in this project, and as such must consider: significant power change, be above a certain amplitude, and be localized. Still, this procedure results in a non distinguishable threshold to separate both groups. Conclusions: Analysis of the receiver operating characteristic (ROC) curves also led to the understanding the method established is not entirely reliable because it cannot in fact determine differences. Since all patients were under treatment with anti-epileptic drugs(AEDs), it becomes necessary to elaborate a pilot study with recently diagnosed subjects where hyperexcitability is still present.Faculdade de Ciências e TecnologiaBraack, EstherPereira, CarlaRUNSantos, Maria Inês Fonseca Silva2013-01-11T09:59:59Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/8502enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:41:09Zoai:run.unl.pt:10362/8502Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:18:14.408456Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Quantification of the TMS-EEG response in epilepsy
title Quantification of the TMS-EEG response in epilepsy
spellingShingle Quantification of the TMS-EEG response in epilepsy
Santos, Maria Inês Fonseca Silva
Epilepsy
Quantification
TMS-EEG
Power
Topography
Amplitude
title_short Quantification of the TMS-EEG response in epilepsy
title_full Quantification of the TMS-EEG response in epilepsy
title_fullStr Quantification of the TMS-EEG response in epilepsy
title_full_unstemmed Quantification of the TMS-EEG response in epilepsy
title_sort Quantification of the TMS-EEG response in epilepsy
author Santos, Maria Inês Fonseca Silva
author_facet Santos, Maria Inês Fonseca Silva
author_role author
dc.contributor.none.fl_str_mv Braack, Esther
Pereira, Carla
RUN
dc.contributor.author.fl_str_mv Santos, Maria Inês Fonseca Silva
dc.subject.por.fl_str_mv Epilepsy
Quantification
TMS-EEG
Power
Topography
Amplitude
topic Epilepsy
Quantification
TMS-EEG
Power
Topography
Amplitude
description Dissertação para obtenção do Grau de Mestre em Engenharia Biomédica
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-01-11T09:59:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/8502
url http://hdl.handle.net/10362/8502
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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