Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1038/s41598-017-02885-9 |
Resumo: | The authors thank Giles Yeo (University of Cambridge, Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Cambridge, United Kingdom) for the excellent mentoring support regarding the microarray data analysis and functional profiling. The excellent contribution of the technicians from the Department of Clinical Pathology (Hospital S. Joao, Porto, Portugal) with the determination of biochemical markers is also gratefully acknowledged. This article was supported by ERDF (European Regional Development Fund) through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013); PEst-OE/SAU/UI0038/2011; SFRH/BPD/109158/2015; SFRH/BD/46640/2008, SFRH/BD/64691/2009, SFRH/BD/78367/2011, SFRH/BD/93073/2013, SFRH/BPD/109153/2015, SFRH/BD/47200/2008, SFRH/BPD/75294/2010; and SFRH/BPD/40110/2007. Editor |
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Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDEPERSISTENT ORGANIC POLLUTANTSENDOCRINE-DISRUPTING CHEMICALSDIPEPTIDYL PEPTIDASE-4 GENE2ND SCIENTIFIC STATEMENTMETABOLIC SYNDROMECARDIOVASCULAR-DISEASEENVIRONMENTAL DISRUPTIONINSULIN-RESISTANCEPROMOTES OBESITYNERVOUS-SYSTEMGeneralSDG 3 - Good Health and Well-beingThe authors thank Giles Yeo (University of Cambridge, Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Cambridge, United Kingdom) for the excellent mentoring support regarding the microarray data analysis and functional profiling. The excellent contribution of the technicians from the Department of Clinical Pathology (Hospital S. Joao, Porto, Portugal) with the determination of biochemical markers is also gratefully acknowledged. This article was supported by ERDF (European Regional Development Fund) through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013); PEst-OE/SAU/UI0038/2011; SFRH/BPD/109158/2015; SFRH/BD/46640/2008, SFRH/BD/64691/2009, SFRH/BD/78367/2011, SFRH/BD/93073/2013, SFRH/BPD/109153/2015, SFRH/BD/47200/2008, SFRH/BPD/75294/2010; and SFRH/BPD/40110/2007. EditorEndocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of metabolic, biochemical and histological parameters. p,p'-DDE -treatment exacerbated several of the metabolic syndrome-accompanying features induced by high-fat diet (HF), such as dyslipidaemia, glucose intolerance and hypertension. A transcriptome analysis comparing mesenteric visceral AT (vAT) of HF and HF/DDE groups revealed a decrease in expression of nervous system and tissue development-related genes, with special relevance for the neuropeptide galanin that also revealed DNA methylation changes at its promoter region. Additionally, we observed an increase in transcription of dipeptidylpeptidase 4, as well as a plasmatic increase of the pro-inflammatory cytokine IL-1β. Our results suggest that p,p'-DDE impairs vAT normal function and effectively decreases the dynamic response to energy surplus. We conclude that p,p'-DDE does not merely accumulate in fat, but may contribute significantly to the development of metabolic dysfunction and inflammation. Our findings reinforce their recognition as metabolism disrupting chemicals, even in non-obesogenic contexts.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPestana, DiogoTeixeira, DianaMeireles, ManuelaMarques, Cláudia SNorberto, SóniaSá, CarlaFernandes, Virgínia C.Correia-Sá, LuísaFaria, Ana S.Guardão, LuísaGuimarães, João T.Cooper, Wendy N.Sandovici, IonelDomingues, Valentina F.Delerue-Matos, CristinaMonteiro, RosárioConstância, MiguelCalhau, Conceição2017-09-22T22:03:38Z2017-06-012017-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttps://doi.org/10.1038/s41598-017-02885-9eng2045-2322PURE: 2985471http://www.scopus.com/inward/record.url?scp=85020232654&partnerID=8YFLogxKhttps://doi.org/10.1038/s41598-017-02885-9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:47Zoai:run.unl.pt:10362/23520Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:49.698854Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| title |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| spellingShingle |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE Pestana, Diogo PERSISTENT ORGANIC POLLUTANTS ENDOCRINE-DISRUPTING CHEMICALS DIPEPTIDYL PEPTIDASE-4 GENE 2ND SCIENTIFIC STATEMENT METABOLIC SYNDROME CARDIOVASCULAR-DISEASE ENVIRONMENTAL DISRUPTION INSULIN-RESISTANCE PROMOTES OBESITY NERVOUS-SYSTEM General SDG 3 - Good Health and Well-being |
| title_short |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| title_full |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| title_fullStr |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| title_full_unstemmed |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| title_sort |
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE |
| author |
Pestana, Diogo |
| author_facet |
Pestana, Diogo Teixeira, Diana Meireles, Manuela Marques, Cláudia S Norberto, Sónia Sá, Carla Fernandes, Virgínia C. Correia-Sá, Luísa Faria, Ana S. Guardão, Luísa Guimarães, João T. Cooper, Wendy N. Sandovici, Ionel Domingues, Valentina F. Delerue-Matos, Cristina Monteiro, Rosário Constância, Miguel Calhau, Conceição |
| author_role |
author |
| author2 |
Teixeira, Diana Meireles, Manuela Marques, Cláudia S Norberto, Sónia Sá, Carla Fernandes, Virgínia C. Correia-Sá, Luísa Faria, Ana S. Guardão, Luísa Guimarães, João T. Cooper, Wendy N. Sandovici, Ionel Domingues, Valentina F. Delerue-Matos, Cristina Monteiro, Rosário Constância, Miguel Calhau, Conceição |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Pestana, Diogo Teixeira, Diana Meireles, Manuela Marques, Cláudia S Norberto, Sónia Sá, Carla Fernandes, Virgínia C. Correia-Sá, Luísa Faria, Ana S. Guardão, Luísa Guimarães, João T. Cooper, Wendy N. Sandovici, Ionel Domingues, Valentina F. Delerue-Matos, Cristina Monteiro, Rosário Constância, Miguel Calhau, Conceição |
| dc.subject.por.fl_str_mv |
PERSISTENT ORGANIC POLLUTANTS ENDOCRINE-DISRUPTING CHEMICALS DIPEPTIDYL PEPTIDASE-4 GENE 2ND SCIENTIFIC STATEMENT METABOLIC SYNDROME CARDIOVASCULAR-DISEASE ENVIRONMENTAL DISRUPTION INSULIN-RESISTANCE PROMOTES OBESITY NERVOUS-SYSTEM General SDG 3 - Good Health and Well-being |
| topic |
PERSISTENT ORGANIC POLLUTANTS ENDOCRINE-DISRUPTING CHEMICALS DIPEPTIDYL PEPTIDASE-4 GENE 2ND SCIENTIFIC STATEMENT METABOLIC SYNDROME CARDIOVASCULAR-DISEASE ENVIRONMENTAL DISRUPTION INSULIN-RESISTANCE PROMOTES OBESITY NERVOUS-SYSTEM General SDG 3 - Good Health and Well-being |
| description |
The authors thank Giles Yeo (University of Cambridge, Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Cambridge, United Kingdom) for the excellent mentoring support regarding the microarray data analysis and functional profiling. The excellent contribution of the technicians from the Department of Clinical Pathology (Hospital S. Joao, Porto, Portugal) with the determination of biochemical markers is also gratefully acknowledged. This article was supported by ERDF (European Regional Development Fund) through the operation POCI-01-0145-FEDER-007746 funded by the Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 and by National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013); PEst-OE/SAU/UI0038/2011; SFRH/BPD/109158/2015; SFRH/BD/46640/2008, SFRH/BD/64691/2009, SFRH/BD/78367/2011, SFRH/BD/93073/2013, SFRH/BPD/109153/2015, SFRH/BD/47200/2008, SFRH/BPD/75294/2010; and SFRH/BPD/40110/2007. Editor |
| publishDate |
2017 |
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2017-09-22T22:03:38Z 2017-06-01 2017-06-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://doi.org/10.1038/s41598-017-02885-9 |
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https://doi.org/10.1038/s41598-017-02885-9 |
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eng |
| language |
eng |
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2045-2322 PURE: 2985471 http://www.scopus.com/inward/record.url?scp=85020232654&partnerID=8YFLogxK https://doi.org/10.1038/s41598-017-02885-9 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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16 application/pdf |
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