Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108954 https://doi.org/10.5935/abc.20140206 |
Resumo: | Background: Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. Objectives: To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. Methods: We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years. The control group consisted of 40 children with normal body mass index within the same age range. Markers of adiposity, plasma lipids and lipoproteins, homeostasis model assessment-insulin resistance, common carotid artery intima-media thickness and left ventricular diameters were analyzed. Results: There were statistically significant differences between the control and obese groups for the variables analyzed, all higher in the obese group, except for age, high-density lipoprotein cholesterol and adiponectin, higher in the control group. In the obese group, body mass index was directly correlated to left ventricular mass (r = 0.542; p = 0.001), the homeostasis model assessment-insulin resistance (r = 0.378; p ≤ 0.001) and mean common carotid artery intima‑media thickness (r = 0.378; p ≤ 0.001). In that same group, insulin resistance was present in 38.1%, 12.5% had a combined dyslipidemic pattern, and eccentric hypertrophy was the most common left ventricular geometric pattern. Conclusions: These results suggest that these markers may be used in clinical practice to stratify cardiovascular risk, as well as to assess the impact of weight control programs. (Arq Bras Cardiol. 2015; 104(4):266-273) |
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Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese childrenPediatric ObesityInsulin ResistanceDyslipidemiasCardiovascular DiseasesAcanthosis NigricansAdiponectinAdolescentAge FactorsBiomarkersBody Mass IndexCardiovascular DiseasesCarotid Intima-Media ThicknessCase-Control StudiesChildCross-Sectional StudiesFemaleHumansHypertrophy, Left VentricularLeptinLipoproteinsMaleRisk FactorsSex FactorsWaist CircumferenceAdiposityDyslipidemiasInsulin ResistancePediatric ObesityBackground: Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. Objectives: To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. Methods: We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years. The control group consisted of 40 children with normal body mass index within the same age range. Markers of adiposity, plasma lipids and lipoproteins, homeostasis model assessment-insulin resistance, common carotid artery intima-media thickness and left ventricular diameters were analyzed. Results: There were statistically significant differences between the control and obese groups for the variables analyzed, all higher in the obese group, except for age, high-density lipoprotein cholesterol and adiponectin, higher in the control group. In the obese group, body mass index was directly correlated to left ventricular mass (r = 0.542; p = 0.001), the homeostasis model assessment-insulin resistance (r = 0.378; p ≤ 0.001) and mean common carotid artery intima‑media thickness (r = 0.378; p ≤ 0.001). In that same group, insulin resistance was present in 38.1%, 12.5% had a combined dyslipidemic pattern, and eccentric hypertrophy was the most common left ventricular geometric pattern. Conclusions: These results suggest that these markers may be used in clinical practice to stratify cardiovascular risk, as well as to assess the impact of weight control programs. (Arq Bras Cardiol. 2015; 104(4):266-273)Sociedad Brasileira De Cardiologia2015-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108954http://hdl.handle.net/10316/108954https://doi.org/10.5935/abc.20140206eng0066-782XPires, AntónioMartins, PaulaPereira, Ana MargaridaSilva, Patricia VazMarinho, JoanaMarques, MargaridaCastela, EduardoSena, Cristina M.Seiça, Raquelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-26T10:31:22Zoai:estudogeral.uc.pt:10316/108954Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:11.346853Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
title |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
spellingShingle |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children Pires, António Pediatric Obesity Insulin Resistance Dyslipidemias Cardiovascular Diseases Acanthosis Nigricans Adiponectin Adolescent Age Factors Biomarkers Body Mass Index Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Child Cross-Sectional Studies Female Humans Hypertrophy, Left Ventricular Leptin Lipoproteins Male Risk Factors Sex Factors Waist Circumference Adiposity Dyslipidemias Insulin Resistance Pediatric Obesity |
title_short |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
title_full |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
title_fullStr |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
title_full_unstemmed |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
title_sort |
Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children |
author |
Pires, António |
author_facet |
Pires, António Martins, Paula Pereira, Ana Margarida Silva, Patricia Vaz Marinho, Joana Marques, Margarida Castela, Eduardo Sena, Cristina M. Seiça, Raquel |
author_role |
author |
author2 |
Martins, Paula Pereira, Ana Margarida Silva, Patricia Vaz Marinho, Joana Marques, Margarida Castela, Eduardo Sena, Cristina M. Seiça, Raquel |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pires, António Martins, Paula Pereira, Ana Margarida Silva, Patricia Vaz Marinho, Joana Marques, Margarida Castela, Eduardo Sena, Cristina M. Seiça, Raquel |
dc.subject.por.fl_str_mv |
Pediatric Obesity Insulin Resistance Dyslipidemias Cardiovascular Diseases Acanthosis Nigricans Adiponectin Adolescent Age Factors Biomarkers Body Mass Index Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Child Cross-Sectional Studies Female Humans Hypertrophy, Left Ventricular Leptin Lipoproteins Male Risk Factors Sex Factors Waist Circumference Adiposity Dyslipidemias Insulin Resistance Pediatric Obesity |
topic |
Pediatric Obesity Insulin Resistance Dyslipidemias Cardiovascular Diseases Acanthosis Nigricans Adiponectin Adolescent Age Factors Biomarkers Body Mass Index Cardiovascular Diseases Carotid Intima-Media Thickness Case-Control Studies Child Cross-Sectional Studies Female Humans Hypertrophy, Left Ventricular Leptin Lipoproteins Male Risk Factors Sex Factors Waist Circumference Adiposity Dyslipidemias Insulin Resistance Pediatric Obesity |
description |
Background: Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders. Objectives: To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort. Methods: We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years. The control group consisted of 40 children with normal body mass index within the same age range. Markers of adiposity, plasma lipids and lipoproteins, homeostasis model assessment-insulin resistance, common carotid artery intima-media thickness and left ventricular diameters were analyzed. Results: There were statistically significant differences between the control and obese groups for the variables analyzed, all higher in the obese group, except for age, high-density lipoprotein cholesterol and adiponectin, higher in the control group. In the obese group, body mass index was directly correlated to left ventricular mass (r = 0.542; p = 0.001), the homeostasis model assessment-insulin resistance (r = 0.378; p ≤ 0.001) and mean common carotid artery intima‑media thickness (r = 0.378; p ≤ 0.001). In that same group, insulin resistance was present in 38.1%, 12.5% had a combined dyslipidemic pattern, and eccentric hypertrophy was the most common left ventricular geometric pattern. Conclusions: These results suggest that these markers may be used in clinical practice to stratify cardiovascular risk, as well as to assess the impact of weight control programs. (Arq Bras Cardiol. 2015; 104(4):266-273) |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108954 http://hdl.handle.net/10316/108954 https://doi.org/10.5935/abc.20140206 |
url |
http://hdl.handle.net/10316/108954 https://doi.org/10.5935/abc.20140206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0066-782X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedad Brasileira De Cardiologia |
publisher.none.fl_str_mv |
Sociedad Brasileira De Cardiologia |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134135081500672 |