Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment

Detalhes bibliográficos
Autor(a) principal: Mano, J. F.
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/34561
Resumo: Strategies in Tissue Engineering and Regenerative Medicine are often based on the use of biomaterials able to support and control cellular activity. Two aspects should be considered in the development of high performance bioinstructive biomaterials. (i) The inherent complexity associated with the multiple possibilities in the biomaterials/cells selection, usually addressed using high-throughput combinatorial tests; and (ii) the unpredictability of the biological outcome of a particular solution. The last facet requires a rational decomposition of the main spatial and temporal cues at the cellular level that drive new-tissue formation upon injury, to be then transposed into adequate biomaterialsâ design. Several nano/micro-technologies may be used to process biomaterials with different shapes and sizes, permitting to engineer biomimetic and hierarchical biomedical devices. As a particular case study, the layer-by-layer assembly method is suggested as a versatile and robust framework to formulate multifunctional and tunable polymer-based biomaterials able to address this exercise of deconstruction and reconstruction.
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spelling Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environmentBiomaterialsBiomimeticsNanobiomaterialsProcessingRegenerative medicineStem cell nicheScience & TechnologyStrategies in Tissue Engineering and Regenerative Medicine are often based on the use of biomaterials able to support and control cellular activity. Two aspects should be considered in the development of high performance bioinstructive biomaterials. (i) The inherent complexity associated with the multiple possibilities in the biomaterials/cells selection, usually addressed using high-throughput combinatorial tests; and (ii) the unpredictability of the biological outcome of a particular solution. The last facet requires a rational decomposition of the main spatial and temporal cues at the cellular level that drive new-tissue formation upon injury, to be then transposed into adequate biomaterialsâ design. Several nano/micro-technologies may be used to process biomaterials with different shapes and sizes, permitting to engineer biomimetic and hierarchical biomedical devices. As a particular case study, the layer-by-layer assembly method is suggested as a versatile and robust framework to formulate multifunctional and tunable polymer-based biomaterials able to address this exercise of deconstruction and reconstruction.The author is grateful for the Portuguese Foundation for Science and Technology (FCT) financial support in the scope of project PTDC/CTM-BIO/1814/2012. The author acknowledges Dr. Iva Pashkuleva for the critical review of the manuscript and Dr. Luca Gasperini for preparation of several schemes.ElsevierUniversidade do MinhoMano, J. F.2015-02-152015-02-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/34561engMano J. F. Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment, Materials Letters, Vol. 141, pp. 198-202, doi:10.1016/j.matlet.2014.11.061, 20150167-577X10.1016/j.matlet.2014.11.061http://www.sciencedirect.com/science/article/pii/S0167577X14020497info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:51:08Zoai:repositorium.sdum.uminho.pt:1822/34561Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:57.788890Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
title Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
spellingShingle Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
Mano, J. F.
Biomaterials
Biomimetics
Nanobiomaterials
Processing
Regenerative medicine
Stem cell niche
Science & Technology
title_short Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
title_full Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
title_fullStr Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
title_full_unstemmed Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
title_sort Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment
author Mano, J. F.
author_facet Mano, J. F.
author_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Mano, J. F.
dc.subject.por.fl_str_mv Biomaterials
Biomimetics
Nanobiomaterials
Processing
Regenerative medicine
Stem cell niche
Science & Technology
topic Biomaterials
Biomimetics
Nanobiomaterials
Processing
Regenerative medicine
Stem cell niche
Science & Technology
description Strategies in Tissue Engineering and Regenerative Medicine are often based on the use of biomaterials able to support and control cellular activity. Two aspects should be considered in the development of high performance bioinstructive biomaterials. (i) The inherent complexity associated with the multiple possibilities in the biomaterials/cells selection, usually addressed using high-throughput combinatorial tests; and (ii) the unpredictability of the biological outcome of a particular solution. The last facet requires a rational decomposition of the main spatial and temporal cues at the cellular level that drive new-tissue formation upon injury, to be then transposed into adequate biomaterialsâ design. Several nano/micro-technologies may be used to process biomaterials with different shapes and sizes, permitting to engineer biomimetic and hierarchical biomedical devices. As a particular case study, the layer-by-layer assembly method is suggested as a versatile and robust framework to formulate multifunctional and tunable polymer-based biomaterials able to address this exercise of deconstruction and reconstruction.
publishDate 2015
dc.date.none.fl_str_mv 2015-02-15
2015-02-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/34561
url http://hdl.handle.net/1822/34561
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mano J. F. Designing biomaterials for tissue engineering based on the deconstruction of the native cellular environment, Materials Letters, Vol. 141, pp. 198-202, doi:10.1016/j.matlet.2014.11.061, 2015
0167-577X
10.1016/j.matlet.2014.11.061
http://www.sciencedirect.com/science/article/pii/S0167577X14020497
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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