Exploring NAD(+) metabolism in host-pathogen interactions

Detalhes bibliográficos
Autor(a) principal: Belinha, Ana
Data de Publicação: 2016
Outros Autores: Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/46276
Resumo: Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
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spelling Exploring NAD(+) metabolism in host-pathogen interactionsNicotinamide adenine dinucleotide (NAD?)Host-pathogen interactionNAD?/NADH ratioNADPH SSirtuinsL-tryptophanNADPHScience & TechnologyNicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.JG was supported by PD/BD/106053/2015. BV was supported by IRD (Institut de Recherche pour le Développement) institutional funding. JE was supported by a European Community’s Seventh Framework Program under grant agreement No. 602773 (Project KINDRED), an ANR grant (LEISH-APO, France) and a Partenariat Hubert Curien (PHC) (program Volubilis, MA/11/262). JE also thanks the Canada Research Chair program for his support. RS thank FCT—Foundation for Science and Technology—for their Investigator FCT Grant (IF/00021/2014)info:eu-repo/semantics/publishedVersionSpringerUniversidade do MinhoBelinha, AnaGaifem, JoanaMesquita, Inês MoraisSilvestre, Ricardo Jorge Leal20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/46276eng1420-682X10.1007/s00018-015-2119-426718485http://link.springer.com/journal/18info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:03Zoai:repositorium.sdum.uminho.pt:1822/46276Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:52:18.402582Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring NAD(+) metabolism in host-pathogen interactions
title Exploring NAD(+) metabolism in host-pathogen interactions
spellingShingle Exploring NAD(+) metabolism in host-pathogen interactions
Belinha, Ana
Nicotinamide adenine dinucleotide (NAD?)
Host-pathogen interaction
NAD?/NADH ratio
NADPH S
Sirtuins
L-tryptophan
NADPH
Science & Technology
title_short Exploring NAD(+) metabolism in host-pathogen interactions
title_full Exploring NAD(+) metabolism in host-pathogen interactions
title_fullStr Exploring NAD(+) metabolism in host-pathogen interactions
title_full_unstemmed Exploring NAD(+) metabolism in host-pathogen interactions
title_sort Exploring NAD(+) metabolism in host-pathogen interactions
author Belinha, Ana
author_facet Belinha, Ana
Gaifem, Joana
Mesquita, Inês Morais
Silvestre, Ricardo Jorge Leal
author_role author
author2 Gaifem, Joana
Mesquita, Inês Morais
Silvestre, Ricardo Jorge Leal
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Belinha, Ana
Gaifem, Joana
Mesquita, Inês Morais
Silvestre, Ricardo Jorge Leal
dc.subject.por.fl_str_mv Nicotinamide adenine dinucleotide (NAD?)
Host-pathogen interaction
NAD?/NADH ratio
NADPH S
Sirtuins
L-tryptophan
NADPH
Science & Technology
topic Nicotinamide adenine dinucleotide (NAD?)
Host-pathogen interaction
NAD?/NADH ratio
NADPH S
Sirtuins
L-tryptophan
NADPH
Science & Technology
description Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/46276
url http://hdl.handle.net/1822/46276
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-682X
10.1007/s00018-015-2119-4
26718485
http://link.springer.com/journal/18
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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