Psoriasis-Associated Vascular Disease: the Role of HDL

Detalhes bibliográficos
Autor(a) principal: Paiva-Lopes, MJ
Data de Publicação: 2017
Outros Autores: Delgado Alves, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2776
Resumo: Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Several cardiovascular disease classical risk factors are also increased in psoriasis but the psoriasis-associated risk persists after adjusting for other risk factors.Investigation has focused on finding explanations for these epidemiological data. Several studies have demonstrated significant lipid metabolism and HDL composition and function alterations in psoriatic patients. Altered HDL function is clearly one of the mechanisms involved, as these particles are of the utmost importance in atherosclerosis defense. Recent data indicate that biologic therapy can reverse both structural and functional HDL alterations in psoriasis, reinforcing their therapeutic potential.
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spelling Psoriasis-Associated Vascular Disease: the Role of HDLHSAC DERPsoriasis/complicationsAtherosclerosis/chemically inducedPsoriasis/epidemiologyAtherosclerosis/epidemiologyCardiovascular Diseases/chemically inducedCardiovascular Diseases/epidemiologyLipid MetabolismLipoproteins, HDL/adverse effectsRisk FactorsPsoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Several cardiovascular disease classical risk factors are also increased in psoriasis but the psoriasis-associated risk persists after adjusting for other risk factors.Investigation has focused on finding explanations for these epidemiological data. Several studies have demonstrated significant lipid metabolism and HDL composition and function alterations in psoriatic patients. Altered HDL function is clearly one of the mechanisms involved, as these particles are of the utmost importance in atherosclerosis defense. Recent data indicate that biologic therapy can reverse both structural and functional HDL alterations in psoriasis, reinforcing their therapeutic potential.BioMed CentralRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEPaiva-Lopes, MJDelgado Alves, J2017-11-03T16:35:35Z2017-09-142017-09-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2776engJ Biomed Sci. 2017 Sep 14;24(1):73.10.1186/s12929-017-0382-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:39:34Zoai:repositorio.chlc.min-saude.pt:10400.17/2776Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:06.552481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Psoriasis-Associated Vascular Disease: the Role of HDL
title Psoriasis-Associated Vascular Disease: the Role of HDL
spellingShingle Psoriasis-Associated Vascular Disease: the Role of HDL
Paiva-Lopes, MJ
HSAC DER
Psoriasis/complications
Atherosclerosis/chemically induced
Psoriasis/epidemiology
Atherosclerosis/epidemiology
Cardiovascular Diseases/chemically induced
Cardiovascular Diseases/epidemiology
Lipid Metabolism
Lipoproteins, HDL/adverse effects
Risk Factors
title_short Psoriasis-Associated Vascular Disease: the Role of HDL
title_full Psoriasis-Associated Vascular Disease: the Role of HDL
title_fullStr Psoriasis-Associated Vascular Disease: the Role of HDL
title_full_unstemmed Psoriasis-Associated Vascular Disease: the Role of HDL
title_sort Psoriasis-Associated Vascular Disease: the Role of HDL
author Paiva-Lopes, MJ
author_facet Paiva-Lopes, MJ
Delgado Alves, J
author_role author
author2 Delgado Alves, J
author2_role author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Paiva-Lopes, MJ
Delgado Alves, J
dc.subject.por.fl_str_mv HSAC DER
Psoriasis/complications
Atherosclerosis/chemically induced
Psoriasis/epidemiology
Atherosclerosis/epidemiology
Cardiovascular Diseases/chemically induced
Cardiovascular Diseases/epidemiology
Lipid Metabolism
Lipoproteins, HDL/adverse effects
Risk Factors
topic HSAC DER
Psoriasis/complications
Atherosclerosis/chemically induced
Psoriasis/epidemiology
Atherosclerosis/epidemiology
Cardiovascular Diseases/chemically induced
Cardiovascular Diseases/epidemiology
Lipid Metabolism
Lipoproteins, HDL/adverse effects
Risk Factors
description Psoriasis is a chronic inflammatory systemic disease with a prevalence of 2-3%. Overwhelming evidence show an epidemiological association between psoriasis, cardiovascular disease and atherosclerosis. Cardiovascular disease is the most frequent cause of death in patients with severe psoriasis. Several cardiovascular disease classical risk factors are also increased in psoriasis but the psoriasis-associated risk persists after adjusting for other risk factors.Investigation has focused on finding explanations for these epidemiological data. Several studies have demonstrated significant lipid metabolism and HDL composition and function alterations in psoriatic patients. Altered HDL function is clearly one of the mechanisms involved, as these particles are of the utmost importance in atherosclerosis defense. Recent data indicate that biologic therapy can reverse both structural and functional HDL alterations in psoriasis, reinforcing their therapeutic potential.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-03T16:35:35Z
2017-09-14
2017-09-14T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2776
url http://hdl.handle.net/10400.17/2776
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Biomed Sci. 2017 Sep 14;24(1):73.
10.1186/s12929-017-0382-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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