Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes

Detalhes bibliográficos
Autor(a) principal: Taccone, F.
Data de Publicação: 2015
Outros Autores: Van den Abeele, A., Bulpa, P., Misset, B., Meersseman, W., Cardoso, T., Paiva, J., Blasco-Navalpotro, M., De Laere, E., Dimopoulos, G., Rello, J., Vogelaers, D., Blot, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/1985
Resumo: INTRODUCTION: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting.
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spelling Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomesINTRODUCTION: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting.METHODS: An observational study including all patients with a positive Aspergillus culture during ICU stay was performed in 30 ICUs in 8 countries. Cases were classified as proven IA, putative IA or Aspergillus colonization according to recently validated criteria. Demographic, microbiologic and diagnostic data were collected. Outcome was recorded 12 weeks after Aspergillus isolation.RESULTS: A total of 563 patients were included, of whom 266 were colonized (47%), 203 had putative IA (36%) and 94 had proven IA (17%). The lung was the most frequent site of infection (94%), and Aspergillus fumigatus the most commonly isolated species (92%). Patients with IA had higher incidences of cancer and organ transplantation than those with colonization. Compared with other patients, they were more frequently diagnosed with sepsis on ICU admission and more frequently received vasopressors and renal replacement therapy (RRT) during the ICU stay. Mortality was 38% among colonized patients, 67% in those with putative IA and 79% in those with proven IA (P < 0.001). Independent risk factors for death among patients with IA included older age, history of bone marrow transplantation, and mechanical ventilation, RRT and higher Sequential Organ Failure Assessment score at diagnosisCONCLUSIONS: IA among critically ill patients is associated with high mortality. Patients diagnosed with proven or putative IA had greater severity of illness and more frequently needed organ support than those with Aspergillus spp colonization.BioMed CentralRepositório Científico do Centro Hospitalar Universitário de Santo AntónioTaccone, F.Van den Abeele, A.Bulpa, P.Misset, B.Meersseman, W.Cardoso, T.Paiva, J.Blasco-Navalpotro, M.De Laere, E.Dimopoulos, G.Rello, J.Vogelaers, D.Blot, S.2016-08-01T10:08:37Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/1985engCrit Care. 2015 Jan 12;19:7.1364-853510.1186/s13054-014-0722-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:58:33Zoai:repositorio.chporto.pt:10400.16/1985Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:17.405852Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
title Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
spellingShingle Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
Taccone, F.
title_short Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
title_full Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
title_fullStr Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
title_full_unstemmed Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
title_sort Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes
author Taccone, F.
author_facet Taccone, F.
Van den Abeele, A.
Bulpa, P.
Misset, B.
Meersseman, W.
Cardoso, T.
Paiva, J.
Blasco-Navalpotro, M.
De Laere, E.
Dimopoulos, G.
Rello, J.
Vogelaers, D.
Blot, S.
author_role author
author2 Van den Abeele, A.
Bulpa, P.
Misset, B.
Meersseman, W.
Cardoso, T.
Paiva, J.
Blasco-Navalpotro, M.
De Laere, E.
Dimopoulos, G.
Rello, J.
Vogelaers, D.
Blot, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Taccone, F.
Van den Abeele, A.
Bulpa, P.
Misset, B.
Meersseman, W.
Cardoso, T.
Paiva, J.
Blasco-Navalpotro, M.
De Laere, E.
Dimopoulos, G.
Rello, J.
Vogelaers, D.
Blot, S.
description INTRODUCTION: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2016-08-01T10:08:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/1985
url http://hdl.handle.net/10400.16/1985
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Crit Care. 2015 Jan 12;19:7.
1364-8535
10.1186/s13054-014-0722-7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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