IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice

Detalhes bibliográficos
Autor(a) principal: Ball, E. A.
Data de Publicação: 2013
Outros Autores: Sambo, M. R., Martins, M., Trovoada, M. J., Benchimol, C., Costa, J., Antunes Goncalves, L., Coutinho, A., Penha-Goncalves, C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/592
Resumo: This publication hasn't any creative commons license associated. There is no public supplementary material available.
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spelling IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected MiceCD8+ T cellsCerebral malariaExperimental Cerebral malariaGenetic associationIFNAR1This publication hasn't any creative commons license associated. There is no public supplementary material available.Development of cerebral malaria (CM), a severe and fatal form of clinical Plasmodium falciparum infection, results from a damaging cascade of vascular, inflammatory, and immunological host responses that leads to brain injury. Progression to CM can be modified by host genetic factors. Our case-control study in Angolan children aimed at highlighting the role of IFN (α, β) receptor 1 (IFNAR1) in progression to CM. We report a robust association between IFNAR1 and CM protection, as well as detailed studies showing analogous protection from experimental CM in Ifnar1(-/-) mice infected with P. berghei ANKA. We developed a novel cell-transfer protocol that enables spleen cell priming in the absence of disease. This led to the discovery that IFNAR1 expression in CD8(+) T cells is crucial and can abrogate resistance to experimental CM in Ifnar1(-/-) mice. Splenic CD8(+) T cells from Ifnar1(-/-) mice are functionally activated upon infection, yet are unable to mediate experimental CM development within the brain tissue. Our findings prove that IFNAR1 signaling unleashes CD8(+) T cell effector capacity, which is vital for CM, and raises the hypothesis that the cohesive role of IFNAR1 in both human and mouse CM operates through CD8(+) T cell triggering.FCT fellowships: (SFRH/BD/33564/2008, SFRH/BPD/29354/2006).The American Association of ImmunologistsARCABall, E. A.Sambo, M. R.Martins, M.Trovoada, M. J.Benchimol, C.Costa, J.Antunes Goncalves, L.Coutinho, A.Penha-Goncalves, C.2016-05-03T17:36:15Z2013-03-062013-03-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/592engBall, E. A., Sambo, M. R., Martins, M., Trovoada, M. J., Benchimol, C., Costa, J., Antunes Goncalves, L., Coutinho, A., Penha-Goncalves, C. (2013). IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice. The Journal of Immunology, 190(10), 5118–5127.10.4049/jimmunol.1300114info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:58Zoai:arca.igc.gulbenkian.pt:10400.7/592Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:50.346611Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
title IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
spellingShingle IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
Ball, E. A.
CD8+ T cells
Cerebral malaria
Experimental Cerebral malaria
Genetic association
IFNAR1
title_short IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
title_full IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
title_fullStr IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
title_full_unstemmed IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
title_sort IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice
author Ball, E. A.
author_facet Ball, E. A.
Sambo, M. R.
Martins, M.
Trovoada, M. J.
Benchimol, C.
Costa, J.
Antunes Goncalves, L.
Coutinho, A.
Penha-Goncalves, C.
author_role author
author2 Sambo, M. R.
Martins, M.
Trovoada, M. J.
Benchimol, C.
Costa, J.
Antunes Goncalves, L.
Coutinho, A.
Penha-Goncalves, C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Ball, E. A.
Sambo, M. R.
Martins, M.
Trovoada, M. J.
Benchimol, C.
Costa, J.
Antunes Goncalves, L.
Coutinho, A.
Penha-Goncalves, C.
dc.subject.por.fl_str_mv CD8+ T cells
Cerebral malaria
Experimental Cerebral malaria
Genetic association
IFNAR1
topic CD8+ T cells
Cerebral malaria
Experimental Cerebral malaria
Genetic association
IFNAR1
description This publication hasn't any creative commons license associated. There is no public supplementary material available.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-06
2013-03-06T00:00:00Z
2016-05-03T17:36:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/592
url http://hdl.handle.net/10400.7/592
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ball, E. A., Sambo, M. R., Martins, M., Trovoada, M. J., Benchimol, C., Costa, J., Antunes Goncalves, L., Coutinho, A., Penha-Goncalves, C. (2013). IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice. The Journal of Immunology, 190(10), 5118–5127.
10.4049/jimmunol.1300114
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The American Association of Immunologists
publisher.none.fl_str_mv The American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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