Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Detalhes bibliográficos
Autor(a) principal: Fernandes, A
Data de Publicação: 2024
Outros Autores: Avraam, D, Cadman, T, Dadvand, P, Guxens, M, Binter, A-C, Pinot de Moira, A, Nieuwenhuijsen, M, Duijts, L, Julvez, J, De Castro, M, Fossati, S, Márquez, S, Vrijkotte, T, Elhakeem, A, McEachan, R, Yang, T, Pedersen, M, Vinther, J, Lepeule, J, Heude, B, Jaddoe, VWV, Santos, S, Welten, M, El Marroun, H, Mian, A, Andrušaitytė, S, Lertxundi, A, Ibarluzea, J, Ballester, F, Esplugues, A, Torres Toda, M, Harris, JR, Lucia Thorbjørnsrud Nader, J, Moirano, G, Maritano, S, Catherine Wilson, R, Vrijheid, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/161154
Resumo: Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European birth cohorts across eight countries. For each participant, we calculated residential Normalized Difference Vegetation Index (NDVI) within a 300 m buffer and the linear distance to green spaces (meters) during prenatal life and childhood. Multiple harmonized health outcomes were selected: asthma and wheezing, lung function, body mass index, diastolic and systolic blood pressure, non-verbal intelligence, internalizing and externalizing problems, and ADHD symptoms. We conducted a two-stage IPD meta-analysis and evaluated effect modification by socioeconomic status (SES) and sex. Between-study heterogeneity was assessed via random-effects meta-regression. Residential surrounding green spaces in childhood, not pregnancy, was associated with improved lung function, particularly higher FEV1 (β = 0.06; 95 %CI: 0.03, 0.09 I2 = 4.03 %, p < 0.001) and FVC (β = 0.07; 95 %CI: 0.04, 0.09 I2 = 0 %, p < 0.001) with a stronger association observed in females (p < 0.001). This association remained robust after multiple testing correction and did not change notably after adjusting for ambient air pollution. Increased distance to green spaces showed an association with lower FVC (β = −0.04; 95 %CI: −0.07, −0.02, I2 = 4.8, p = 0.001), with a stronger effect in children from higher SES backgrounds (p < 0.001). No consistent associations were found between green spaces and asthma, wheezing, cardiometabolic, or neurodevelopmental outcomes, with direction of effect varying across cohorts. Wheezing and neurodevelopmental outcomes showed high between-study heterogeneity, and the age at outcome assessment was only associated with heterogeneity in internalizing problems. This large European meta-analysis suggests that childhood exposure to green spaces may lead to better lung function. Associations with other respiratory outcomes and selected cardiometabolic and neurodevelopmental outcomes remain inconclusive. © 2024 The Authors
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spelling Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European childrenStudies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European birth cohorts across eight countries. For each participant, we calculated residential Normalized Difference Vegetation Index (NDVI) within a 300 m buffer and the linear distance to green spaces (meters) during prenatal life and childhood. Multiple harmonized health outcomes were selected: asthma and wheezing, lung function, body mass index, diastolic and systolic blood pressure, non-verbal intelligence, internalizing and externalizing problems, and ADHD symptoms. We conducted a two-stage IPD meta-analysis and evaluated effect modification by socioeconomic status (SES) and sex. Between-study heterogeneity was assessed via random-effects meta-regression. Residential surrounding green spaces in childhood, not pregnancy, was associated with improved lung function, particularly higher FEV1 (β = 0.06; 95 %CI: 0.03, 0.09 I2 = 4.03 %, p < 0.001) and FVC (β = 0.07; 95 %CI: 0.04, 0.09 I2 = 0 %, p < 0.001) with a stronger association observed in females (p < 0.001). This association remained robust after multiple testing correction and did not change notably after adjusting for ambient air pollution. Increased distance to green spaces showed an association with lower FVC (β = −0.04; 95 %CI: −0.07, −0.02, I2 = 4.8, p = 0.001), with a stronger effect in children from higher SES backgrounds (p < 0.001). No consistent associations were found between green spaces and asthma, wheezing, cardiometabolic, or neurodevelopmental outcomes, with direction of effect varying across cohorts. Wheezing and neurodevelopmental outcomes showed high between-study heterogeneity, and the age at outcome assessment was only associated with heterogeneity in internalizing problems. This large European meta-analysis suggests that childhood exposure to green spaces may lead to better lung function. Associations with other respiratory outcomes and selected cardiometabolic and neurodevelopmental outcomes remain inconclusive. © 2024 The AuthorsElsevier20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/161154eng0160-412010.1016/j.envint.2024.108853Fernandes, AAvraam, DCadman, TDadvand, PGuxens, MBinter, A-CPinot de Moira, ANieuwenhuijsen, MDuijts, LJulvez, JDe Castro, MFossati, SMárquez, SVrijkotte, TElhakeem, AMcEachan, RYang, TPedersen, MVinther, JLepeule, JHeude, BJaddoe, VWVSantos, SWelten, MEl Marroun, HMian, AAndrušaitytė, SLertxundi, AIbarluzea, JBallester, FEsplugues, ATorres Toda, MHarris, JRLucia Thorbjørnsrud Nader, JMoirano, GMaritano, SCatherine Wilson, RVrijheid, Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T08:10:20Zoai:repositorio-aberto.up.pt:10216/161154Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T08:10:20Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
title Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
spellingShingle Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
Fernandes, A
title_short Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
title_full Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
title_fullStr Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
title_full_unstemmed Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
title_sort Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
author Fernandes, A
author_facet Fernandes, A
Avraam, D
Cadman, T
Dadvand, P
Guxens, M
Binter, A-C
Pinot de Moira, A
Nieuwenhuijsen, M
Duijts, L
Julvez, J
De Castro, M
Fossati, S
Márquez, S
Vrijkotte, T
Elhakeem, A
McEachan, R
Yang, T
Pedersen, M
Vinther, J
Lepeule, J
Heude, B
Jaddoe, VWV
Santos, S
Welten, M
El Marroun, H
Mian, A
Andrušaitytė, S
Lertxundi, A
Ibarluzea, J
Ballester, F
Esplugues, A
Torres Toda, M
Harris, JR
Lucia Thorbjørnsrud Nader, J
Moirano, G
Maritano, S
Catherine Wilson, R
Vrijheid, M
author_role author
author2 Avraam, D
Cadman, T
Dadvand, P
Guxens, M
Binter, A-C
Pinot de Moira, A
Nieuwenhuijsen, M
Duijts, L
Julvez, J
De Castro, M
Fossati, S
Márquez, S
Vrijkotte, T
Elhakeem, A
McEachan, R
Yang, T
Pedersen, M
Vinther, J
Lepeule, J
Heude, B
Jaddoe, VWV
Santos, S
Welten, M
El Marroun, H
Mian, A
Andrušaitytė, S
Lertxundi, A
Ibarluzea, J
Ballester, F
Esplugues, A
Torres Toda, M
Harris, JR
Lucia Thorbjørnsrud Nader, J
Moirano, G
Maritano, S
Catherine Wilson, R
Vrijheid, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, A
Avraam, D
Cadman, T
Dadvand, P
Guxens, M
Binter, A-C
Pinot de Moira, A
Nieuwenhuijsen, M
Duijts, L
Julvez, J
De Castro, M
Fossati, S
Márquez, S
Vrijkotte, T
Elhakeem, A
McEachan, R
Yang, T
Pedersen, M
Vinther, J
Lepeule, J
Heude, B
Jaddoe, VWV
Santos, S
Welten, M
El Marroun, H
Mian, A
Andrušaitytė, S
Lertxundi, A
Ibarluzea, J
Ballester, F
Esplugues, A
Torres Toda, M
Harris, JR
Lucia Thorbjørnsrud Nader, J
Moirano, G
Maritano, S
Catherine Wilson, R
Vrijheid, M
description Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiometabolic, and neurodevelopmental outcomes in school-age children. We performed an Individual-Participant Data (IPD) meta-analysis involving 35,000 children from ten European birth cohorts across eight countries. For each participant, we calculated residential Normalized Difference Vegetation Index (NDVI) within a 300 m buffer and the linear distance to green spaces (meters) during prenatal life and childhood. Multiple harmonized health outcomes were selected: asthma and wheezing, lung function, body mass index, diastolic and systolic blood pressure, non-verbal intelligence, internalizing and externalizing problems, and ADHD symptoms. We conducted a two-stage IPD meta-analysis and evaluated effect modification by socioeconomic status (SES) and sex. Between-study heterogeneity was assessed via random-effects meta-regression. Residential surrounding green spaces in childhood, not pregnancy, was associated with improved lung function, particularly higher FEV1 (β = 0.06; 95 %CI: 0.03, 0.09 I2 = 4.03 %, p < 0.001) and FVC (β = 0.07; 95 %CI: 0.04, 0.09 I2 = 0 %, p < 0.001) with a stronger association observed in females (p < 0.001). This association remained robust after multiple testing correction and did not change notably after adjusting for ambient air pollution. Increased distance to green spaces showed an association with lower FVC (β = −0.04; 95 %CI: −0.07, −0.02, I2 = 4.8, p = 0.001), with a stronger effect in children from higher SES backgrounds (p < 0.001). No consistent associations were found between green spaces and asthma, wheezing, cardiometabolic, or neurodevelopmental outcomes, with direction of effect varying across cohorts. Wheezing and neurodevelopmental outcomes showed high between-study heterogeneity, and the age at outcome assessment was only associated with heterogeneity in internalizing problems. This large European meta-analysis suggests that childhood exposure to green spaces may lead to better lung function. Associations with other respiratory outcomes and selected cardiometabolic and neurodevelopmental outcomes remain inconclusive. © 2024 The Authors
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/161154
url https://hdl.handle.net/10216/161154
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0160-4120
10.1016/j.envint.2024.108853
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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