Neurodevelopmental outcomes in children with congenital hypothyroidism

Detalhes bibliográficos
Autor(a) principal: Almeida, Carolina Lopes de
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/33417
Resumo: Trabalho de revisão do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.
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spelling Neurodevelopmental outcomes in children with congenital hypothyroidismCongenital HypothyroidismChildScreening programNeurodevelopmental disorderCognitionTrabalho de revisão do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.Although prognosis of Congenital Hypothyroidism (CH) has been greatly modified since the introduction of newborn screening programs, persistent cognitive deficits are still reported. The aim of this study was to evaluate neurodevelopmental outcomes of children with CH and to determine whether severity of CH, age of start of L-thyroxine supplementation and control of CH play an important role. We analyzed a sample of children with CH (N=44) using neurodevelopmental assessment tests according to child’s age and level of functioning: Griffiths Scale of Mental Development (GSMD), Portuguese version of Wechsler Intelligence Scale for Children – Third Edition (WISC-III), and Vineland Adaptive Behaviour Scale (VABS) and early developmental milestones. We further compared this data with screening TSH values and follow-up mean values of TSH, fT4 and L-thyroxine dosage. Communication Disorders and Attention-Deficit/Hyperactivity Disorder were the most common diagnosis, 25% and 15.9% respectively, found among children with neurodevelopmental problems (59.1%). Average scores in Practical Reasoning Quotient in the Griffiths subscale and Adaptive Behaviour Composite, Daily Living Skills and Socialization (VABS domains) in children with CH were significantly lower than in normal population. A correlation was found between mean L-thyroxine dosage and Full Scale Intelligence Quotient (WISC-III). No correlation was found between screening level of TSH, age of treatment initiation, follow-up mean TSH, mean fT4 values and results in the three global scales of neurodevelopmental tests. Even though prognosis of CH has been greatly modified since early detection through screening programs, careful monitoring of these children is crucial to guarantee an early intervention and to assure optimal neuro- and sociodevelopmental outcomes.2016-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10316/33417http://hdl.handle.net/10316/33417engAlmeida, Carolina Lopes deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-01-20T17:48:45Zoai:estudogeral.uc.pt:10316/33417Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:44:07.492554Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Neurodevelopmental outcomes in children with congenital hypothyroidism
title Neurodevelopmental outcomes in children with congenital hypothyroidism
spellingShingle Neurodevelopmental outcomes in children with congenital hypothyroidism
Almeida, Carolina Lopes de
Congenital Hypothyroidism
Child
Screening program
Neurodevelopmental disorder
Cognition
title_short Neurodevelopmental outcomes in children with congenital hypothyroidism
title_full Neurodevelopmental outcomes in children with congenital hypothyroidism
title_fullStr Neurodevelopmental outcomes in children with congenital hypothyroidism
title_full_unstemmed Neurodevelopmental outcomes in children with congenital hypothyroidism
title_sort Neurodevelopmental outcomes in children with congenital hypothyroidism
author Almeida, Carolina Lopes de
author_facet Almeida, Carolina Lopes de
author_role author
dc.contributor.author.fl_str_mv Almeida, Carolina Lopes de
dc.subject.por.fl_str_mv Congenital Hypothyroidism
Child
Screening program
Neurodevelopmental disorder
Cognition
topic Congenital Hypothyroidism
Child
Screening program
Neurodevelopmental disorder
Cognition
description Trabalho de revisão do 6º ano médico com vista à atribuição do grau de mestre (área científica de pediatria) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/33417
http://hdl.handle.net/10316/33417
url http://hdl.handle.net/10316/33417
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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