The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate

Detalhes bibliográficos
Autor(a) principal: Alves, Rosana
Data de Publicação: 2017
Outros Autores: Mota, Sandra, Silva, Sónia, F. Rodrigues, Célia, P. Brown, Alistair J., Henriques, Mariana, Casal, Margarida, Paiva, Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/14499
Resumo: Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process. The results show that growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole and that both Jen1 and Jen2 might play a role in these processes. These results support the view that the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity.
id RCAP_d79612ca32c95b2b8eefda0f0d8f1f64
oai_identifier_str oai:recipp.ipp.pt:10400.22/14499
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactateAdaptation, PhysiologicalAntifungal AgentsBiofilmsBiofoulingCandida albicansCarboxylic AcidsCellular MicroenvironmentDrug Resistance, FungalFluconazoleFungal ProteinsGlucoseLactic AcidMonocarboxylic Acid TransportersCandida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process. The results show that growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole and that both Jen1 and Jen2 might play a role in these processes. These results support the view that the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity.Taylor & FrancisRepositório Científico do Instituto Politécnico do PortoAlves, RosanaMota, SandraSilva, SóniaF. Rodrigues, CéliaP. Brown, Alistair J.Henriques, MarianaCasal, MargaridaPaiva, Sandra2019-07-29T16:19:56Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/14499eng10.1080/08927014.2017.1392514info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:57:57Zoai:recipp.ipp.pt:10400.22/14499Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:34:21.586510Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
title The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
spellingShingle The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
Alves, Rosana
Adaptation, Physiological
Antifungal Agents
Biofilms
Biofouling
Candida albicans
Carboxylic Acids
Cellular Microenvironment
Drug Resistance, Fungal
Fluconazole
Fungal Proteins
Glucose
Lactic Acid
Monocarboxylic Acid Transporters
title_short The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
title_full The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
title_fullStr The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
title_full_unstemmed The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
title_sort The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
author Alves, Rosana
author_facet Alves, Rosana
Mota, Sandra
Silva, Sónia
F. Rodrigues, Célia
P. Brown, Alistair J.
Henriques, Mariana
Casal, Margarida
Paiva, Sandra
author_role author
author2 Mota, Sandra
Silva, Sónia
F. Rodrigues, Célia
P. Brown, Alistair J.
Henriques, Mariana
Casal, Margarida
Paiva, Sandra
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Alves, Rosana
Mota, Sandra
Silva, Sónia
F. Rodrigues, Célia
P. Brown, Alistair J.
Henriques, Mariana
Casal, Margarida
Paiva, Sandra
dc.subject.por.fl_str_mv Adaptation, Physiological
Antifungal Agents
Biofilms
Biofouling
Candida albicans
Carboxylic Acids
Cellular Microenvironment
Drug Resistance, Fungal
Fluconazole
Fungal Proteins
Glucose
Lactic Acid
Monocarboxylic Acid Transporters
topic Adaptation, Physiological
Antifungal Agents
Biofilms
Biofouling
Candida albicans
Carboxylic Acids
Cellular Microenvironment
Drug Resistance, Fungal
Fluconazole
Fungal Proteins
Glucose
Lactic Acid
Monocarboxylic Acid Transporters
description Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process. The results show that growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole and that both Jen1 and Jen2 might play a role in these processes. These results support the view that the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2019-07-29T16:19:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/14499
url http://hdl.handle.net/10400.22/14499
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1080/08927014.2017.1392514
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799131435662049280