Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.79.1.1287 |
Resumo: | Introduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy. |
id |
RCAP_d7aa6e7d1c0336882b4e361837ee8b56 |
---|---|
oai_identifier_str |
oai:ojs.revista.spdv.com.pt:article/1287 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic DermatitisAnálise da Correlação Entre os Níveis Séricos de Vitamina D e a Gravidade da Dermatite AtópicaVitamin D/bloodDermatitis, AtopicVitamin D DeficiencyDeficiência de Vitamina DDermatite AtópicaVitamina D/sangueIntroduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.Introdução: A dermatite atópica (DA) é uma doença inflamatória crônica e multifatorial. Casos graves afetam a qualidade de vida. A patogénese é complexa, marcada por resposta imune celular defeituosa, exacerbação da resposta inflamatória Th2 e comprometimento da função de barreira da pele. Evidências sugerem que a vitamina D atua na regulação da resposta imune inata e adaptativa, na redução do processo inflamatório e na melhora da barreira cutânea. O nosso objectivo foi correlacionar os níveis séricos de vitamina D com a gravidade da DA. Material e Métodos: Foram analisados prontuários de 30 pacientes assistidos em um ambulatório de Dermatologia, entre 2015 e 2018. Os pacientes foram divididos em 2 grupos: doença leve (terapia tópica) e doença moderada a grave (usuários de imunossupressores). Resultados: Foram selecionados 10 casos com DA leve e 20 com DA moderada a grave. Entre os pacientes com doença leve, 20% apresentaram deficiência de vitamina D. Quanto aos pacientes com doença moderada a grave, 40% apresentaram vitamina D deficiente. Comparando a média de vitamina D nos dois grupos, não houve diferença estatística entre o valor médio. Conclusão: Estudos sobre associação entre os níveis de vitamina D e gravidade da DA permanecem controversos. Alguns trabalhos reforçam essa associação. Neste estudo, apesar da proporção de pacientes com deficiência de vitamina D ser duas vezes maior entre os pacientes com DA moderada a grave, não houve significância estatística entre os dois grupos, corroborando estudos já publicados. Mais estudos relacionando a dermatite atópica à vitamina D são desejáveis, tendo em vista a sua possível aplicabilidade como terapêutica auxiliar.Sociedade Portuguesa de Dermatologia e Venereologia2021-04-05T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.79.1.1287oai:ojs.revista.spdv.com.pt:article/1287Journal of the Portuguese Society of Dermatology and Venereology; Vol 79 No 1 (2021): January - March; 37-40Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 79 n. 1 (2021): Janeiro - Março; 37-402182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/1287https://doi.org/10.29021/spdv.79.1.1287https://revista.spdv.com.pt/index.php/spdv/article/view/1287/883Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereologyhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCâmara Mariz, Julianade Moura Barros, Noramide Oliveira Martins, BárbaraLopes Bressan, Aline2022-10-06T12:35:17Zoai:ojs.revista.spdv.com.pt:article/1287Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:18.534437Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis Análise da Correlação Entre os Níveis Séricos de Vitamina D e a Gravidade da Dermatite Atópica |
title |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
spellingShingle |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis Câmara Mariz, Juliana Vitamin D/blood Dermatitis, Atopic Vitamin D Deficiency Deficiência de Vitamina D Dermatite Atópica Vitamina D/sangue |
title_short |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
title_full |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
title_fullStr |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
title_full_unstemmed |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
title_sort |
Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis |
author |
Câmara Mariz, Juliana |
author_facet |
Câmara Mariz, Juliana de Moura Barros, Norami de Oliveira Martins, Bárbara Lopes Bressan, Aline |
author_role |
author |
author2 |
de Moura Barros, Norami de Oliveira Martins, Bárbara Lopes Bressan, Aline |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Câmara Mariz, Juliana de Moura Barros, Norami de Oliveira Martins, Bárbara Lopes Bressan, Aline |
dc.subject.por.fl_str_mv |
Vitamin D/blood Dermatitis, Atopic Vitamin D Deficiency Deficiência de Vitamina D Dermatite Atópica Vitamina D/sangue |
topic |
Vitamin D/blood Dermatitis, Atopic Vitamin D Deficiency Deficiência de Vitamina D Dermatite Atópica Vitamina D/sangue |
description |
Introduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-05T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.79.1.1287 oai:ojs.revista.spdv.com.pt:article/1287 |
url |
https://doi.org/10.29021/spdv.79.1.1287 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/1287 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/1287 https://doi.org/10.29021/spdv.79.1.1287 https://revista.spdv.com.pt/index.php/spdv/article/view/1287/883 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereology https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 79 No 1 (2021): January - March; 37-40 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 79 n. 1 (2021): Janeiro - Março; 37-40 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799130568526397440 |