Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis

Detalhes bibliográficos
Autor(a) principal: Câmara Mariz, Juliana
Data de Publicação: 2021
Outros Autores: de Moura Barros, Norami, de Oliveira Martins, Bárbara, Lopes Bressan, Aline
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.79.1.1287
Resumo: Introduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.
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spelling Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic DermatitisAnálise da Correlação Entre os Níveis Séricos de Vitamina D e a Gravidade da Dermatite AtópicaVitamin D/bloodDermatitis, AtopicVitamin D DeficiencyDeficiência de Vitamina DDermatite AtópicaVitamina D/sangueIntroduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.Introdução: A dermatite atópica (DA) é uma doença inflamatória crônica e multifatorial. Casos graves afetam a qualidade de vida. A patogénese é complexa, marcada por resposta imune celular defeituosa, exacerbação da resposta inflamatória Th2 e comprometimento da função de barreira da pele. Evidências sugerem que a vitamina D atua na regulação da resposta imune inata e adaptativa, na redução do processo inflamatório e na melhora da barreira cutânea. O nosso objectivo foi correlacionar os níveis séricos de vitamina D com a gravidade da DA. Material e Métodos: Foram analisados prontuários de 30 pacientes assistidos em um ambulatório de Dermatologia, entre 2015 e 2018. Os pacientes foram divididos em 2 grupos: doença leve (terapia tópica) e doença moderada a grave (usuários de imunossupressores). Resultados: Foram selecionados 10 casos com DA leve e 20 com DA moderada a grave. Entre os pacientes com doença leve, 20% apresentaram deficiência de vitamina D. Quanto aos pacientes com doença moderada a grave, 40% apresentaram vitamina D deficiente. Comparando a média de vitamina D nos dois grupos, não houve diferença estatística entre o valor médio. Conclusão: Estudos sobre associação entre os níveis de vitamina D e gravidade da DA permanecem controversos. Alguns trabalhos reforçam essa associação. Neste estudo, apesar da proporção de pacientes com deficiência de vitamina D ser duas vezes maior entre os pacientes com DA moderada a grave, não houve significância estatística entre os dois grupos, corroborando estudos já publicados. Mais estudos relacionando a dermatite atópica à vitamina D são desejáveis, tendo em vista a sua possível aplicabilidade como terapêutica auxiliar.Sociedade Portuguesa de Dermatologia e Venereologia2021-04-05T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.79.1.1287oai:ojs.revista.spdv.com.pt:article/1287Journal of the Portuguese Society of Dermatology and Venereology; Vol 79 No 1 (2021): January - March; 37-40Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 79 n. 1 (2021): Janeiro - Março; 37-402182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/1287https://doi.org/10.29021/spdv.79.1.1287https://revista.spdv.com.pt/index.php/spdv/article/view/1287/883Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereologyhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCâmara Mariz, Julianade Moura Barros, Noramide Oliveira Martins, BárbaraLopes Bressan, Aline2022-10-06T12:35:17Zoai:ojs.revista.spdv.com.pt:article/1287Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:18.534437Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
Análise da Correlação Entre os Níveis Séricos de Vitamina D e a Gravidade da Dermatite Atópica
title Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
spellingShingle Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
Câmara Mariz, Juliana
Vitamin D/blood
Dermatitis, Atopic
Vitamin D Deficiency
Deficiência de Vitamina D
Dermatite Atópica
Vitamina D/sangue
title_short Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
title_full Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
title_fullStr Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
title_full_unstemmed Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
title_sort Analysis of the Correlation Between Serum Vitamin D Levels and Severity of Atopic Dermatitis
author Câmara Mariz, Juliana
author_facet Câmara Mariz, Juliana
de Moura Barros, Norami
de Oliveira Martins, Bárbara
Lopes Bressan, Aline
author_role author
author2 de Moura Barros, Norami
de Oliveira Martins, Bárbara
Lopes Bressan, Aline
author2_role author
author
author
dc.contributor.author.fl_str_mv Câmara Mariz, Juliana
de Moura Barros, Norami
de Oliveira Martins, Bárbara
Lopes Bressan, Aline
dc.subject.por.fl_str_mv Vitamin D/blood
Dermatitis, Atopic
Vitamin D Deficiency
Deficiência de Vitamina D
Dermatite Atópica
Vitamina D/sangue
topic Vitamin D/blood
Dermatitis, Atopic
Vitamin D Deficiency
Deficiência de Vitamina D
Dermatite Atópica
Vitamina D/sangue
description Introduction: Atopic dermatitis (AD) is a chronic inflammatory multifactorial disease. Severe cases affect the quality of life. The pathogenesis is complex, marked by defective cellular immune system, exacerbation of Th2-type immune response and impaired skin barrier function. Studies suggest that vitamin D acts in the regulation of the innate and adaptive immune response, reduces the inflammatory process and improves the skin barrier. Our objective was to correlate vitamin D serum levels with the severity of AD. Material and Methods: Between 2015 and 2018 the authors evaluated 30 patients aged between 18 and 90 years old, under treatment at a Dermatology ambulatory clinic. Patients were divided into 2 groups: mild disease (only topical therapy) and moderate to severe disease (under immunosuppressive treatment). Results: Ten cases with mild AD and 20 with moderate to severe AD were selected. Among patients with mild disease, 20% had vitamin D deficiency. As for patients with moderate to severe disease, 40% had a deficient serum level of 25-hydroxyvitamin D. Comparing the average vitamin D in the two groups, there was no statistical difference between them. Conclusion: In the literature, the association between vitamin D levels and the severity of AD remain controversial, although some studies support this association. In this study, despite the proportion of patients with 25-hydroxyvitamin D deficiency being twice as high among patients with moderate to severe AD, there was no statistical significance between the groups, corroborating previous manuscripts. Clinical studies relating atopic dermatitis to vitamin D are warranted, considering its possible use as a concomitant therapy.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-05T00:00:00Z
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dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.79.1.1287
oai:ojs.revista.spdv.com.pt:article/1287
url https://doi.org/10.29021/spdv.79.1.1287
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/1287
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dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/1287
https://doi.org/10.29021/spdv.79.1.1287
https://revista.spdv.com.pt/index.php/spdv/article/view/1287/883
dc.rights.driver.fl_str_mv Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereology
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Journal of the Portuguese Society of Dermatology and Venereology
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 79 No 1 (2021): January - March; 37-40
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 79 n. 1 (2021): Janeiro - Março; 37-40
2182-2409
2182-2395
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