Atopic dermatitis and vitamin D: facts and controversies

Detalhes bibliográficos
Autor(a) principal: Mesquita,Kleyton de Carvalho
Data de Publicação: 2013
Outros Autores: Igreja,Ana Carolina de Souza Machado, Costa,Izelda Maria Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600945
Resumo: Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. In this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.
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spelling Atopic dermatitis and vitamin D: facts and controversiesDefensinsDermatitis, atopicVitamin DVitamin D DeficiencyPatients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. In this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.Sociedade Brasileira de Dermatologia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600945Anais Brasileiros de Dermatologia v.88 n.6 2013reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20132660info:eu-repo/semantics/openAccessMesquita,Kleyton de CarvalhoIgreja,Ana Carolina de Souza MachadoCosta,Izelda Maria Carvalhoeng2014-08-29T00:00:00Zoai:scielo:S0365-05962013000600945Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2014-08-29T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Atopic dermatitis and vitamin D: facts and controversies
title Atopic dermatitis and vitamin D: facts and controversies
spellingShingle Atopic dermatitis and vitamin D: facts and controversies
Mesquita,Kleyton de Carvalho
Defensins
Dermatitis, atopic
Vitamin D
Vitamin D Deficiency
title_short Atopic dermatitis and vitamin D: facts and controversies
title_full Atopic dermatitis and vitamin D: facts and controversies
title_fullStr Atopic dermatitis and vitamin D: facts and controversies
title_full_unstemmed Atopic dermatitis and vitamin D: facts and controversies
title_sort Atopic dermatitis and vitamin D: facts and controversies
author Mesquita,Kleyton de Carvalho
author_facet Mesquita,Kleyton de Carvalho
Igreja,Ana Carolina de Souza Machado
Costa,Izelda Maria Carvalho
author_role author
author2 Igreja,Ana Carolina de Souza Machado
Costa,Izelda Maria Carvalho
author2_role author
author
dc.contributor.author.fl_str_mv Mesquita,Kleyton de Carvalho
Igreja,Ana Carolina de Souza Machado
Costa,Izelda Maria Carvalho
dc.subject.por.fl_str_mv Defensins
Dermatitis, atopic
Vitamin D
Vitamin D Deficiency
topic Defensins
Dermatitis, atopic
Vitamin D
Vitamin D Deficiency
description Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. In this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600945
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600945
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20132660
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.88 n.6 2013
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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