A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ana Catarina Freitas Salazar
Data de Publicação: 2020
Outros Autores: Neves, N. M., Reis, R. L., Martins, Albino, Silva, Tiago H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65368
Resumo: "Available online 09 March 2020"
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spelling A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systemsFucoidanAntitumorCompoundSystemsScience & Technology"Available online 09 March 2020"Due to the severe side-effects and the toxicity to healthy tissues, cancer treatments based in chemotherapy have not fully achieved the desire outcomes so far. The use of natural compound may be of great value to develop better tolerated therapies. Fucoidan is a marine sulfated polysaccharide extracted from brown algae that, besides other biological activities, has been reported to present interesting anti-cancer potential. This review briefly introduces fucoidan chemical structure, physicochemical properties and the above-mentioned biological feature. Fucoidan usage as soluble agent presents promising results herein described for different types of cancer. Trying to enhance and optimize fucoidan usage in the cancer field, different systems, namely drug delivery, have been recently developed to target different types of cancers. This aspect will be presented in detail, highlighting the role of fucoidan on their reported or envisaged performance.This work was developed under the scope of the Structured projects for R&D&I NORTE-01-0145-FEDER-000021 and NORTE-01-0145-FEDER-000023 supported by the Northern Portugal Regional Operational Programme (NORTE 2020), and the Mobilizing Project ValorMar, POCI-01-0247-FEDER-024517, supported by the Operational Programme for Competitiveness and Internationalization (COMPETE 2020), under the Portugal 2020 Partnership Agreement, co-funded by European Regional Development Fund (ERDF). The authors would like also to thank NORTE 2020, for financing the PhD scholarship of C.O. “Norte-08-5369-000037” and Portuguese Foundation for Science and Technology for the Investigator grant of A.M. (IF/00376/2014).ElsevierUniversidade do MinhoOliveira, Ana Catarina Freitas SalazarNeves, N. M.Reis, R. L.Martins, AlbinoSilva, Tiago H.2020-072020-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65368engOliveira C., Neves N. M., Reis R. L., Martins A., Silva T. H. A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems, Carbohydrate Polymers, Vol. 239, doi:10.1016/j.carbpol.2020.116131, 20200144-86171879-134410.1016/j.carbpol.2020.1161313241445510.1016/j.carbpol.2020.116131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:40Zoai:repositorium.sdum.uminho.pt:1822/65368Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:23:31.009083Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
title A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
spellingShingle A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
Oliveira, Ana Catarina Freitas Salazar
Fucoidan
Antitumor
Compound
Systems
Science & Technology
title_short A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
title_full A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
title_fullStr A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
title_full_unstemmed A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
title_sort A review on fucoidan antitumor strategies: from a biological active agent to a structural component of fucoidan-based systems
author Oliveira, Ana Catarina Freitas Salazar
author_facet Oliveira, Ana Catarina Freitas Salazar
Neves, N. M.
Reis, R. L.
Martins, Albino
Silva, Tiago H.
author_role author
author2 Neves, N. M.
Reis, R. L.
Martins, Albino
Silva, Tiago H.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Ana Catarina Freitas Salazar
Neves, N. M.
Reis, R. L.
Martins, Albino
Silva, Tiago H.
dc.subject.por.fl_str_mv Fucoidan
Antitumor
Compound
Systems
Science & Technology
topic Fucoidan
Antitumor
Compound
Systems
Science & Technology
description "Available online 09 March 2020"
publishDate 2020
dc.date.none.fl_str_mv 2020-07
2020-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65368
url http://hdl.handle.net/1822/65368
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira C., Neves N. M., Reis R. L., Martins A., Silva T. H. A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems, Carbohydrate Polymers, Vol. 239, doi:10.1016/j.carbpol.2020.116131, 2020
0144-8617
1879-1344
10.1016/j.carbpol.2020.116131
32414455
10.1016/j.carbpol.2020.116131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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