Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/20049 |
Resumo: | The final publication is available at Springer via http://dx.doi.org/10.1007/s13346-016-0303-1 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modelingControlled drug releaseHydrogelsContact lensesMicrofluidicsNumerical simulationThe final publication is available at Springer via http://dx.doi.org/10.1007/s13346-016-0303-1Currently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo. In this work, a microfluidic cell was designed and used to mimic the continuous, volumetric flow rate of tear fluid and its low volume. The suitable operation of the cell, in terms of uniformity and symmetry of flux, was proved using a numerical model based in the Navier-Stokes and continuity equations. The release profile of a model system (a hydroxyethyl methacrylate-based hydrogel (HEMA/PVP) for soft contact lenses (SCLs) loaded with diclofenac) obtained with the microfluidic cell was compared with that obtained in static conditions, showing that the kinetics of release in dynamic conditions is slower. The application of the numerical model demonstrated that the designed cell can be used to simulate the drug release in the whole range of the human eye tear film volume and allowed to estimate the drug concentration in the volume of liquid in direct contact with the hydrogel. The knowledge of this concentration, which is significantly different from that measured in the experimental tests during the first hours of release, is critical to predict the toxicity of the drug release system and its in vivo efficacy. In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug-loaded SCLs.SpringerRepositório ComumPimenta, A. F. R.Valente, A.Pereira, J. M. C.Pereira, J. C. F.Filipe, H. P.Mata, J. L. G.Colaço, R.Saramago, B.Serro, A. P.2018-01-10T15:38:49Z2016-12-01T00:00:00Z2016-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/20049engPimenta, A.F.R., Valente, A., Pereira, J.M.C. et al. Drug Deliv. and Transl. Res. (2016) 6: 755. https://doi.org/10.1007/s13346-016-0303-12190-393X10.1007/s13346-016-0303-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:13Zoai:comum.rcaap.pt:10400.26/20049Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:09.093590Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| title |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| spellingShingle |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling Pimenta, A. F. R. Controlled drug release Hydrogels Contact lenses Microfluidics Numerical simulation |
| title_short |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| title_full |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| title_fullStr |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| title_full_unstemmed |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| title_sort |
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling |
| author |
Pimenta, A. F. R. |
| author_facet |
Pimenta, A. F. R. Valente, A. Pereira, J. M. C. Pereira, J. C. F. Filipe, H. P. Mata, J. L. G. Colaço, R. Saramago, B. Serro, A. P. |
| author_role |
author |
| author2 |
Valente, A. Pereira, J. M. C. Pereira, J. C. F. Filipe, H. P. Mata, J. L. G. Colaço, R. Saramago, B. Serro, A. P. |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Pimenta, A. F. R. Valente, A. Pereira, J. M. C. Pereira, J. C. F. Filipe, H. P. Mata, J. L. G. Colaço, R. Saramago, B. Serro, A. P. |
| dc.subject.por.fl_str_mv |
Controlled drug release Hydrogels Contact lenses Microfluidics Numerical simulation |
| topic |
Controlled drug release Hydrogels Contact lenses Microfluidics Numerical simulation |
| description |
The final publication is available at Springer via http://dx.doi.org/10.1007/s13346-016-0303-1 |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-12-01T00:00:00Z 2016-12-01T00:00:00Z 2018-01-10T15:38:49Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/20049 |
| url |
http://hdl.handle.net/10400.26/20049 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Pimenta, A.F.R., Valente, A., Pereira, J.M.C. et al. Drug Deliv. and Transl. Res. (2016) 6: 755. https://doi.org/10.1007/s13346-016-0303-1 2190-393X 10.1007/s13346-016-0303-1 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Springer |
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Springer |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129960342880256 |