MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/18581 |
Resumo: | Long-term behavioral consequences of the neurotoxicity produced by 3,4-methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% saline in the same protocol. Ten days after exposure, the behavioral effects of MDMA were assessed in the elevated plus-maze (n = 6 per group). After behavioral testing, animals were sacrificed and the amygdalae were dissected and processed for HPLC determination of dopamine (DA), serotonin (5-HT), and metabolites. Results showed a significant decrease in the 5-HT content (P < 0.05), but no significant alterations in DA or its metabolites. Behavioral observation in the elevated plus-maze showed a decreased number of entries in the unprotected arms (P < 0.05), which were correlated to the number of entries and time spent in the central platform. Rearing was also decreased (P < 0.05). No differences were observed in head dips, grooming, or number of entries in the protected arms of the apparatus. Therefore, we conclude that, as in the adult rat, exposure to MDMA in the adolescent rat is associated to long-term depletion of the 5-HT content and increased anxiety-like behavior. |
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MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze testMDMAEcstasySerotoninDopamineAmygdalaAnxietyLong-term behavioral consequences of the neurotoxicity produced by 3,4-methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% saline in the same protocol. Ten days after exposure, the behavioral effects of MDMA were assessed in the elevated plus-maze (n = 6 per group). After behavioral testing, animals were sacrificed and the amygdalae were dissected and processed for HPLC determination of dopamine (DA), serotonin (5-HT), and metabolites. Results showed a significant decrease in the 5-HT content (P < 0.05), but no significant alterations in DA or its metabolites. Behavioral observation in the elevated plus-maze showed a decreased number of entries in the unprotected arms (P < 0.05), which were correlated to the number of entries and time spent in the central platform. Rearing was also decreased (P < 0.05). No differences were observed in head dips, grooming, or number of entries in the protected arms of the apparatus. Therefore, we conclude that, as in the adult rat, exposure to MDMA in the adolescent rat is associated to long-term depletion of the 5-HT content and increased anxiety-like behavior.WileyRepositório Científico do Instituto Politécnico do PortoFaria, RaquelMagalhães, AnaMonteiro, PedroSilva, Joana Gomes daTavares, Maria AméliaSummavielle, Teresa2021-09-28T07:54:40Z2006-09-062006-09-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/18581engFaria, R., Magalhães, A., Monteiro, P. R. R., Gomes-da-Silva, J., Tavares, M. A., & Summavielle, T. (2006). MDMA in adolescent male rats. Annals of the New York Academy of Sciences, 1074(1), 643-649. https://doi.org/https://doi.org/10.1196/annals.1369.0621749-663210.1196/annals.1369.062info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:10:20Zoai:recipp.ipp.pt:10400.22/18581Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:38:07.571363Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
title |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
spellingShingle |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test Faria, Raquel MDMA Ecstasy Serotonin Dopamine Amygdala Anxiety |
title_short |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
title_full |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
title_fullStr |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
title_full_unstemmed |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
title_sort |
MDA in adolescent male rats - decreased serotonin in the amygdala and behavioral effects in the elevated plus-maze test |
author |
Faria, Raquel |
author_facet |
Faria, Raquel Magalhães, Ana Monteiro, Pedro Silva, Joana Gomes da Tavares, Maria Amélia Summavielle, Teresa |
author_role |
author |
author2 |
Magalhães, Ana Monteiro, Pedro Silva, Joana Gomes da Tavares, Maria Amélia Summavielle, Teresa |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Faria, Raquel Magalhães, Ana Monteiro, Pedro Silva, Joana Gomes da Tavares, Maria Amélia Summavielle, Teresa |
dc.subject.por.fl_str_mv |
MDMA Ecstasy Serotonin Dopamine Amygdala Anxiety |
topic |
MDMA Ecstasy Serotonin Dopamine Amygdala Anxiety |
description |
Long-term behavioral consequences of the neurotoxicity produced by 3,4-methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% saline in the same protocol. Ten days after exposure, the behavioral effects of MDMA were assessed in the elevated plus-maze (n = 6 per group). After behavioral testing, animals were sacrificed and the amygdalae were dissected and processed for HPLC determination of dopamine (DA), serotonin (5-HT), and metabolites. Results showed a significant decrease in the 5-HT content (P < 0.05), but no significant alterations in DA or its metabolites. Behavioral observation in the elevated plus-maze showed a decreased number of entries in the unprotected arms (P < 0.05), which were correlated to the number of entries and time spent in the central platform. Rearing was also decreased (P < 0.05). No differences were observed in head dips, grooming, or number of entries in the protected arms of the apparatus. Therefore, we conclude that, as in the adult rat, exposure to MDMA in the adolescent rat is associated to long-term depletion of the 5-HT content and increased anxiety-like behavior. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-09-06 2006-09-06T00:00:00Z 2021-09-28T07:54:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/18581 |
url |
http://hdl.handle.net/10400.22/18581 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Faria, R., Magalhães, A., Monteiro, P. R. R., Gomes-da-Silva, J., Tavares, M. A., & Summavielle, T. (2006). MDMA in adolescent male rats. Annals of the New York Academy of Sciences, 1074(1), 643-649. https://doi.org/https://doi.org/10.1196/annals.1369.062 1749-6632 10.1196/annals.1369.062 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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