E-cadherin deregulation in breast cancer

Detalhes bibliográficos
Autor(a) principal: Corso, G
Data de Publicação: 2020
Outros Autores: Figueiredo, J, Angelis, SP, Corso, F, Girardi, A, Pereira, J, Seruca, R, Bonanni, B, Carneiro, P, Pravettoni, G, Guerini Rocco, E, Veronesi, P, Montagna, G, Sacchini, V, Gandini, S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/142516
Resumo: E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
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spelling E-cadherin deregulation in breast cancerE-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.Wiley20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/142516eng1582-183810.1111/jcmm.15140Corso, GFigueiredo, JAngelis, SPCorso, FGirardi, APereira, JSeruca, RBonanni, BCarneiro, PPravettoni, GGuerini Rocco, EVeronesi, PMontagna, GSacchini, VGandini, Sinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:45:01Zoai:repositorio-aberto.up.pt:10216/142516Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:31:08.875578Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv E-cadherin deregulation in breast cancer
title E-cadherin deregulation in breast cancer
spellingShingle E-cadherin deregulation in breast cancer
Corso, G
title_short E-cadherin deregulation in breast cancer
title_full E-cadherin deregulation in breast cancer
title_fullStr E-cadherin deregulation in breast cancer
title_full_unstemmed E-cadherin deregulation in breast cancer
title_sort E-cadherin deregulation in breast cancer
author Corso, G
author_facet Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
author_role author
author2 Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
description E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/142516
url https://hdl.handle.net/10216/142516
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1582-1838
10.1111/jcmm.15140
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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