Biotechnological applications of bacteriophages: state of the art
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/54758 |
Resumo: | Bacteriophage particles are the most abundant biological entities on our planet, infecting specific bacterial hosts in every known environment and being major drivers of bacterial adaptive evolution. The study of bacteriophage particles potentially sheds light on the development of new biotechnology products. Bacteriophage therapy, although not new, makes use of strictly lytic phage particles as an alternative in the antimicrobial treatment of resistant bacterial infections and is being rediscovered as a safe method due to the fact that these biological entities devoid of any metabolic machinery do not have affinity to eukaryotic cells. Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. This review paper discusses the biological nature of bacteriophage particles, their mode(s) of action and potential exploitation in modern biotechnology. Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene delivery, food biopreservation and safety, biocontrol of plant pathogens, phage display, bacterial biosensing devices, vaccines and vaccine carriers, biofilm and bacterial growth control, surface disinfection, corrosion control, together with structural and functional stabilization issues. |
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Biotechnological applications of bacteriophages: state of the artBacteriophagesPhage therapyPhage displayBacterial biosensingVaccine carriersGene deliveryFood biopreservation and safetyBiofilm controlSurface disinfectionCorrosion controlStructural and functional stabilizationScience & TechnologyBacteriophage particles are the most abundant biological entities on our planet, infecting specific bacterial hosts in every known environment and being major drivers of bacterial adaptive evolution. The study of bacteriophage particles potentially sheds light on the development of new biotechnology products. Bacteriophage therapy, although not new, makes use of strictly lytic phage particles as an alternative in the antimicrobial treatment of resistant bacterial infections and is being rediscovered as a safe method due to the fact that these biological entities devoid of any metabolic machinery do not have affinity to eukaryotic cells. Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. This review paper discusses the biological nature of bacteriophage particles, their mode(s) of action and potential exploitation in modern biotechnology. Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene delivery, food biopreservation and safety, biocontrol of plant pathogens, phage display, bacterial biosensing devices, vaccines and vaccine carriers, biofilm and bacterial growth control, surface disinfection, corrosion control, together with structural and functional stabilization issues.Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) (FAPESP Refs. No. 2016/08884- 3 (Project PneumoPhageColor) and 2016/12234-4 (Project TransAppIL)), is hereby gratefully acknowledged. Funding by Fundação de Amparo à Pesquisa do Estado de São Paulo(FAPESP Ref. No. 2016/ 16641-3) in the form of an M.Sc. fellowship granted to Liliam Harada is hereby gratefully acknowledged. This work also received support from CNPq, National Council for Scientific and Technological Development Brazil, in the form of Research Productivity (PQ) fellowships granted to Victor M. Balcão (Refs. No. 306113/2014-7 and 308208/2017-0). Financial support to Krystyna Dąbrowska by the National Science Centre in Poland (Grant UMO-2012/05/E/NZ6/03314) is also gratefully acknowledged. The authors have no conflicts of interest whatsoever to declare.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoHarada, Liliam K.Silva, Erica C.Campos, Welida F.Del Fiol, Fernando S.Vila, Marta M. D. C.Dabrowska, KrystynaKrylov, Victor N.Balcão, Victor M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/54758engHarada, Liliam K.; Silva, Erica C.; Campos, Welida F.; Del Fiol, Fernando S.; Vila, Marta; Dabrowska, Krystyna; Krylov, Victor N.; Balcão, Victor M., Biotechnological applications of bacteriophages: State of the art. Microbiological Research, 212-213, 38-58, 20180944-50130944-501310.1016/j.micres.2018.04.00729853167https://www.journals.elsevier.com/microbiological-researchinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:38:50Zoai:repositorium.sdum.uminho.pt:1822/54758Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:38:50Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biotechnological applications of bacteriophages: state of the art |
title |
Biotechnological applications of bacteriophages: state of the art |
spellingShingle |
Biotechnological applications of bacteriophages: state of the art Harada, Liliam K. Bacteriophages Phage therapy Phage display Bacterial biosensing Vaccine carriers Gene delivery Food biopreservation and safety Biofilm control Surface disinfection Corrosion control Structural and functional stabilization Science & Technology |
title_short |
Biotechnological applications of bacteriophages: state of the art |
title_full |
Biotechnological applications of bacteriophages: state of the art |
title_fullStr |
Biotechnological applications of bacteriophages: state of the art |
title_full_unstemmed |
Biotechnological applications of bacteriophages: state of the art |
title_sort |
Biotechnological applications of bacteriophages: state of the art |
author |
Harada, Liliam K. |
author_facet |
Harada, Liliam K. Silva, Erica C. Campos, Welida F. Del Fiol, Fernando S. Vila, Marta M. D. C. Dabrowska, Krystyna Krylov, Victor N. Balcão, Victor M. |
author_role |
author |
author2 |
Silva, Erica C. Campos, Welida F. Del Fiol, Fernando S. Vila, Marta M. D. C. Dabrowska, Krystyna Krylov, Victor N. Balcão, Victor M. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Harada, Liliam K. Silva, Erica C. Campos, Welida F. Del Fiol, Fernando S. Vila, Marta M. D. C. Dabrowska, Krystyna Krylov, Victor N. Balcão, Victor M. |
dc.subject.por.fl_str_mv |
Bacteriophages Phage therapy Phage display Bacterial biosensing Vaccine carriers Gene delivery Food biopreservation and safety Biofilm control Surface disinfection Corrosion control Structural and functional stabilization Science & Technology |
topic |
Bacteriophages Phage therapy Phage display Bacterial biosensing Vaccine carriers Gene delivery Food biopreservation and safety Biofilm control Surface disinfection Corrosion control Structural and functional stabilization Science & Technology |
description |
Bacteriophage particles are the most abundant biological entities on our planet, infecting specific bacterial hosts in every known environment and being major drivers of bacterial adaptive evolution. The study of bacteriophage particles potentially sheds light on the development of new biotechnology products. Bacteriophage therapy, although not new, makes use of strictly lytic phage particles as an alternative in the antimicrobial treatment of resistant bacterial infections and is being rediscovered as a safe method due to the fact that these biological entities devoid of any metabolic machinery do not have affinity to eukaryotic cells. Furthermore, bacteriophage-based vaccination is emerging as one of the most promising preventive strategies. This review paper discusses the biological nature of bacteriophage particles, their mode(s) of action and potential exploitation in modern biotechnology. Topics covered in detail include the potential of bacteriophage particles in human infections (bacteriophage therapy), nanocages for gene delivery, food biopreservation and safety, biocontrol of plant pathogens, phage display, bacterial biosensing devices, vaccines and vaccine carriers, biofilm and bacterial growth control, surface disinfection, corrosion control, together with structural and functional stabilization issues. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/54758 |
url |
http://hdl.handle.net/1822/54758 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Harada, Liliam K.; Silva, Erica C.; Campos, Welida F.; Del Fiol, Fernando S.; Vila, Marta; Dabrowska, Krystyna; Krylov, Victor N.; Balcão, Victor M., Biotechnological applications of bacteriophages: State of the art. Microbiological Research, 212-213, 38-58, 2018 0944-5013 0944-5013 10.1016/j.micres.2018.04.007 29853167 https://www.journals.elsevier.com/microbiological-research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545389756121088 |