Different genomic changes underlie adaptive evolution in populations of contrasting history

Detalhes bibliográficos
Autor(a) principal: Seabra, Sofia G.
Data de Publicação: 2018
Outros Autores: Fragata, Inês, Antunes, M. A., Faria, Gonçalo S., Santos, Marta A., Sousa, Vitor C., Simões, Pedro, Matos, Margarida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149353
Resumo: Funding Information: This work was supported by Portuguese National Funds through “Fundac¸ão para a Ciência e a Tecnologia” (projects PTDC/ BIA-BEC/098213/2008, PTDC/BIA-BIC/2165/2012 and cE3c Unit FCT funding UID/BIA/00329/2013, grants SFRH/BD/ 60734/2009 to I.F. and SFRH/BPD/86186/2012 to P.S.). We thank Miguel Lopes-Cunha for help in the laboratory, Francisco Pina-Martins for help with computing, Josiane Santos and Ana Sofia Quina for discussions, and Mauro Santos and Anthony Long for advice on the study and comments on the manuscript. We also thank the three anonymous reviewers for their constructive suggestions.
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spelling Different genomic changes underlie adaptive evolution in populations of contrasting historyAdaptationAllele trajectoriesEvolveExperimental evolutionGenomic evolutionHistoryResequenceEcology, Evolution, Behavior and SystematicsMolecular BiologyGeneticsFunding Information: This work was supported by Portuguese National Funds through “Fundac¸ão para a Ciência e a Tecnologia” (projects PTDC/ BIA-BEC/098213/2008, PTDC/BIA-BIC/2165/2012 and cE3c Unit FCT funding UID/BIA/00329/2013, grants SFRH/BD/ 60734/2009 to I.F. and SFRH/BPD/86186/2012 to P.S.). We thank Miguel Lopes-Cunha for help in the laboratory, Francisco Pina-Martins for help with computing, Josiane Santos and Ana Sofia Quina for discussions, and Mauro Santos and Anthony Long for advice on the study and comments on the manuscript. We also thank the three anonymous reviewers for their constructive suggestions.Experimental evolution is a powerful tool to understand the adaptive potential of populations under environmental change. Here, we study the importance of the historical genetic background in the outcome of evolution at the genomewide level. Using the natural clinal variation of Drosophila subobscura, we sampled populations from two contrasting latitudes (Adraga, Portugal and Groningen, Netherlands) and introduced them in a new common environment in the laboratory. We characterized the genome-wide temporal changes underlying the evolutionary dynamics of these populations, which had previously shown fast convergence at the phenotypic level, but not at chromosomal inversion frequencies. We found that initially differentiated populations did not converge either at genome-wide level or at candidate SNPs with signs of selection. In contrast, populations from Portugal showed convergence to the control population that derived from the same geographical origin and had been long-established in the laboratory. Candidate SNPs showed a variety of different allele frequency change patterns across generations, indicative of an underlying polygenic basis. We did not detect strong linkage around candidate SNPs, but rather a small but long-ranging effect. In conclusion, we found that history played a major role in genomic variation and evolution, with initially differentiated populations reaching the same adaptive outcome through different genetic routes.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSeabra, Sofia G.Fragata, InêsAntunes, M. A.Faria, Gonçalo S.Santos, Marta A.Sousa, Vitor C.Simões, PedroMatos, Margarida2023-02-16T22:23:19Z2018-03-012018-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/149353eng0737-4038PURE: 53454088https://doi.org/10.1093/molbev/msx247info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:18Zoai:run.unl.pt:10362/149353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:44.065158Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Different genomic changes underlie adaptive evolution in populations of contrasting history
title Different genomic changes underlie adaptive evolution in populations of contrasting history
spellingShingle Different genomic changes underlie adaptive evolution in populations of contrasting history
Seabra, Sofia G.
Adaptation
Allele trajectories
Evolve
Experimental evolution
Genomic evolution
History
Resequence
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
title_short Different genomic changes underlie adaptive evolution in populations of contrasting history
title_full Different genomic changes underlie adaptive evolution in populations of contrasting history
title_fullStr Different genomic changes underlie adaptive evolution in populations of contrasting history
title_full_unstemmed Different genomic changes underlie adaptive evolution in populations of contrasting history
title_sort Different genomic changes underlie adaptive evolution in populations of contrasting history
author Seabra, Sofia G.
author_facet Seabra, Sofia G.
Fragata, Inês
Antunes, M. A.
Faria, Gonçalo S.
Santos, Marta A.
Sousa, Vitor C.
Simões, Pedro
Matos, Margarida
author_role author
author2 Fragata, Inês
Antunes, M. A.
Faria, Gonçalo S.
Santos, Marta A.
Sousa, Vitor C.
Simões, Pedro
Matos, Margarida
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Seabra, Sofia G.
Fragata, Inês
Antunes, M. A.
Faria, Gonçalo S.
Santos, Marta A.
Sousa, Vitor C.
Simões, Pedro
Matos, Margarida
dc.subject.por.fl_str_mv Adaptation
Allele trajectories
Evolve
Experimental evolution
Genomic evolution
History
Resequence
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
topic Adaptation
Allele trajectories
Evolve
Experimental evolution
Genomic evolution
History
Resequence
Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics
description Funding Information: This work was supported by Portuguese National Funds through “Fundac¸ão para a Ciência e a Tecnologia” (projects PTDC/ BIA-BEC/098213/2008, PTDC/BIA-BIC/2165/2012 and cE3c Unit FCT funding UID/BIA/00329/2013, grants SFRH/BD/ 60734/2009 to I.F. and SFRH/BPD/86186/2012 to P.S.). We thank Miguel Lopes-Cunha for help in the laboratory, Francisco Pina-Martins for help with computing, Josiane Santos and Ana Sofia Quina for discussions, and Mauro Santos and Anthony Long for advice on the study and comments on the manuscript. We also thank the three anonymous reviewers for their constructive suggestions.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-01
2018-03-01T00:00:00Z
2023-02-16T22:23:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149353
url http://hdl.handle.net/10362/149353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0737-4038
PURE: 53454088
https://doi.org/10.1093/molbev/msx247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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