Host adaptation to viruses relies on few genes with different cross-resistance properties

Detalhes bibliográficos
Autor(a) principal: Martins, N. E.
Data de Publicação: 2014
Outros Autores: Faria, V. G., Nolte, V., Schlotterer, C., Teixeira, L., Sucena, E., Magalhaes, S.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/801
Resumo: The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.
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spelling Host adaptation to viruses relies on few genes with different cross-resistance propertieshost–parasite interactionsexperimental evolutionDrosophila immunityevolve and resequenceThe deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.Host adaptation to one parasite may affect its response to others. However, the genetics of these direct and correlated responses remains poorly studied. The overlap between these responses is instrumental for the understanding of host evolution in multiparasite environments. We determined the genetic and phenotypic changes underlying adaptation of Drosophila melanogaster to Drosophila C virus (DCV). Within 20 generations, flies selected with DCV showed increased survival after DCV infection, but also after cricket paralysis virus (CrPV) and flock house virus (FHV) infection. Whole-genome sequencing identified two regions of significant differentiation among treatments, from which candidate genes were functionally tested with RNAi. Three genes were validated--pastrel, a known DCV-response gene, and two other loci, Ubc-E2H and CG8492. Knockdown of Ubc-E2H and pastrel also led to increased sensitivity to CrPV, whereas knockdown of CG8492 increased susceptibility to FHV infection. Therefore, Drosophila adaptation to DCV relies on few major genes, each with different cross-resistance properties, conferring host resistance to several parasites.Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/62964/2009, SFRH/BD/82299/2011, PTDC/SAU-IMU/120673/2010); Austrian Science Fund grants: (P22725, P19467); European Research Council grant: (ArchAdapt); Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian; Vetmeduni.National Academy of SciencesARCAMartins, N. E.Faria, V. G.Nolte, V.Schlotterer, C.Teixeira, L.Sucena, E.Magalhaes, S.2017-11-06T19:05:28Z2014-04-222014-04-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/801porNelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 2014 111 (16) 5938-5943; published ahead of print April 7, 2014, doi:10.1073/pnas.140037811110.1073/pnas.1400378111info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:12Zoai:arca.igc.gulbenkian.pt:10400.7/801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:01.537335Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Host adaptation to viruses relies on few genes with different cross-resistance properties
title Host adaptation to viruses relies on few genes with different cross-resistance properties
spellingShingle Host adaptation to viruses relies on few genes with different cross-resistance properties
Martins, N. E.
host–parasite interactions
experimental evolution
Drosophila immunity
evolve and resequence
title_short Host adaptation to viruses relies on few genes with different cross-resistance properties
title_full Host adaptation to viruses relies on few genes with different cross-resistance properties
title_fullStr Host adaptation to viruses relies on few genes with different cross-resistance properties
title_full_unstemmed Host adaptation to viruses relies on few genes with different cross-resistance properties
title_sort Host adaptation to viruses relies on few genes with different cross-resistance properties
author Martins, N. E.
author_facet Martins, N. E.
Faria, V. G.
Nolte, V.
Schlotterer, C.
Teixeira, L.
Sucena, E.
Magalhaes, S.
author_role author
author2 Faria, V. G.
Nolte, V.
Schlotterer, C.
Teixeira, L.
Sucena, E.
Magalhaes, S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Martins, N. E.
Faria, V. G.
Nolte, V.
Schlotterer, C.
Teixeira, L.
Sucena, E.
Magalhaes, S.
dc.subject.por.fl_str_mv host–parasite interactions
experimental evolution
Drosophila immunity
evolve and resequence
topic host–parasite interactions
experimental evolution
Drosophila immunity
evolve and resequence
description The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-22
2014-04-22T00:00:00Z
2017-11-06T19:05:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/801
url http://hdl.handle.net/10400.7/801
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Nelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 2014 111 (16) 5938-5943; published ahead of print April 7, 2014, doi:10.1073/pnas.1400378111
10.1073/pnas.1400378111
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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