Host adaptation to viruses relies on few genes with different cross-resistance properties
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/801 |
Resumo: | The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Host adaptation to viruses relies on few genes with different cross-resistance propertieshost–parasite interactionsexperimental evolutionDrosophila immunityevolve and resequenceThe deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.Host adaptation to one parasite may affect its response to others. However, the genetics of these direct and correlated responses remains poorly studied. The overlap between these responses is instrumental for the understanding of host evolution in multiparasite environments. We determined the genetic and phenotypic changes underlying adaptation of Drosophila melanogaster to Drosophila C virus (DCV). Within 20 generations, flies selected with DCV showed increased survival after DCV infection, but also after cricket paralysis virus (CrPV) and flock house virus (FHV) infection. Whole-genome sequencing identified two regions of significant differentiation among treatments, from which candidate genes were functionally tested with RNAi. Three genes were validated--pastrel, a known DCV-response gene, and two other loci, Ubc-E2H and CG8492. Knockdown of Ubc-E2H and pastrel also led to increased sensitivity to CrPV, whereas knockdown of CG8492 increased susceptibility to FHV infection. Therefore, Drosophila adaptation to DCV relies on few major genes, each with different cross-resistance properties, conferring host resistance to several parasites.Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/62964/2009, SFRH/BD/82299/2011, PTDC/SAU-IMU/120673/2010); Austrian Science Fund grants: (P22725, P19467); European Research Council grant: (ArchAdapt); Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian; Vetmeduni.National Academy of SciencesARCAMartins, N. E.Faria, V. G.Nolte, V.Schlotterer, C.Teixeira, L.Sucena, E.Magalhaes, S.2017-11-06T19:05:28Z2014-04-222014-04-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/801porNelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 2014 111 (16) 5938-5943; published ahead of print April 7, 2014, doi:10.1073/pnas.140037811110.1073/pnas.1400378111info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:12Zoai:arca.igc.gulbenkian.pt:10400.7/801Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:01.537335Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
title |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
spellingShingle |
Host adaptation to viruses relies on few genes with different cross-resistance properties Martins, N. E. host–parasite interactions experimental evolution Drosophila immunity evolve and resequence |
title_short |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
title_full |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
title_fullStr |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
title_full_unstemmed |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
title_sort |
Host adaptation to viruses relies on few genes with different cross-resistance properties |
author |
Martins, N. E. |
author_facet |
Martins, N. E. Faria, V. G. Nolte, V. Schlotterer, C. Teixeira, L. Sucena, E. Magalhaes, S. |
author_role |
author |
author2 |
Faria, V. G. Nolte, V. Schlotterer, C. Teixeira, L. Sucena, E. Magalhaes, S. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Martins, N. E. Faria, V. G. Nolte, V. Schlotterer, C. Teixeira, L. Sucena, E. Magalhaes, S. |
dc.subject.por.fl_str_mv |
host–parasite interactions experimental evolution Drosophila immunity evolve and resequence |
topic |
host–parasite interactions experimental evolution Drosophila immunity evolve and resequence |
description |
The deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-22 2014-04-22T00:00:00Z 2017-11-06T19:05:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/801 |
url |
http://hdl.handle.net/10400.7/801 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Nelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 2014 111 (16) 5938-5943; published ahead of print April 7, 2014, doi:10.1073/pnas.1400378111 10.1073/pnas.1400378111 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
National Academy of Sciences |
publisher.none.fl_str_mv |
National Academy of Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130575784640512 |