Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants

Detalhes bibliográficos
Autor(a) principal: Barreto, M.
Data de Publicação: 2007
Outros Autores: Ferreira, RC., Lourenço, L., Moraes-Fontes, MF., Santos, E., Alves, M., Carvalho, C., Martins, B., Andreia, R., Viana, JF., Vasconcelos, C., Mota-Vieira, L., Ferreira, C., Demengeot, J., Vicente, AM.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/160
Resumo: Background: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females.
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spelling Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variantsREGULATORY T-CELLSSYSTEMIC-LUPUS-ERYTHEMATOSUSIMMUNOLOGICAL SELF-TOLERANCEIN-VIVO EXPANSIONAUTOANTIBODY PRODUCTIONMULTIPLE-SCLEROSISBackground: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females.Biomed CentralARCABarreto, M.Ferreira, RC.Lourenço, L.Moraes-Fontes, MF.Santos, E.Alves, M.Carvalho, C.Martins, B.Andreia, R.Viana, JF.Vasconcelos, C.Mota-Vieira, L.Ferreira, C.Demengeot, J.Vicente, AM.2010-08-11T11:10:29Z2007-01-272007-01-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/160engBarreto, M., Ferreira, R.C., Lourenco, L., Moraes-Fontes, M.F.,Santos, E., Alves, M.,Carvalho, C., Martins, B., Andreia, R., Viana, J. F., Vasconcelos, C., Mota-Vieira, L., Ferreira, C., Demengeot, J., Vicente, A.M. (2009). “Low frequency of CD4(+)CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants”. BMC Immunology. 10: 1 -141471-2172info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:40Zoai:arca.igc.gulbenkian.pt:10400.7/160Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:35.974109Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
title Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
spellingShingle Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
Barreto, M.
REGULATORY T-CELLS
SYSTEMIC-LUPUS-ERYTHEMATOSUS
IMMUNOLOGICAL SELF-TOLERANCE
IN-VIVO EXPANSION
AUTOANTIBODY PRODUCTION
MULTIPLE-SCLEROSIS
title_short Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
title_full Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
title_fullStr Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
title_full_unstemmed Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
title_sort Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants
author Barreto, M.
author_facet Barreto, M.
Ferreira, RC.
Lourenço, L.
Moraes-Fontes, MF.
Santos, E.
Alves, M.
Carvalho, C.
Martins, B.
Andreia, R.
Viana, JF.
Vasconcelos, C.
Mota-Vieira, L.
Ferreira, C.
Demengeot, J.
Vicente, AM.
author_role author
author2 Ferreira, RC.
Lourenço, L.
Moraes-Fontes, MF.
Santos, E.
Alves, M.
Carvalho, C.
Martins, B.
Andreia, R.
Viana, JF.
Vasconcelos, C.
Mota-Vieira, L.
Ferreira, C.
Demengeot, J.
Vicente, AM.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Barreto, M.
Ferreira, RC.
Lourenço, L.
Moraes-Fontes, MF.
Santos, E.
Alves, M.
Carvalho, C.
Martins, B.
Andreia, R.
Viana, JF.
Vasconcelos, C.
Mota-Vieira, L.
Ferreira, C.
Demengeot, J.
Vicente, AM.
dc.subject.por.fl_str_mv REGULATORY T-CELLS
SYSTEMIC-LUPUS-ERYTHEMATOSUS
IMMUNOLOGICAL SELF-TOLERANCE
IN-VIVO EXPANSION
AUTOANTIBODY PRODUCTION
MULTIPLE-SCLEROSIS
topic REGULATORY T-CELLS
SYSTEMIC-LUPUS-ERYTHEMATOSUS
IMMUNOLOGICAL SELF-TOLERANCE
IN-VIVO EXPANSION
AUTOANTIBODY PRODUCTION
MULTIPLE-SCLEROSIS
description Background: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-27
2007-01-27T00:00:00Z
2010-08-11T11:10:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/160
url http://hdl.handle.net/10400.7/160
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Barreto, M., Ferreira, R.C., Lourenco, L., Moraes-Fontes, M.F.,Santos, E., Alves, M.,Carvalho, C., Martins, B., Andreia, R., Viana, J. F., Vasconcelos, C., Mota-Vieira, L., Ferreira, C., Demengeot, J., Vicente, A.M. (2009). “Low frequency of CD4(+)CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants”. BMC Immunology. 10: 1 -14
1471-2172
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biomed Central
publisher.none.fl_str_mv Biomed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130571463458816

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