Tacrolimus: a forgotten agent in kidney transplant leukopenia

Detalhes bibliográficos
Autor(a) principal: Azevedo,Pedro
Data de Publicação: 2013
Outros Autores: Freitas,Cristina, Silva,Hugo, Aguiar,Pedro, Santos,Teresa, Cabral,João, Rocha,Guilherme, Almeida,Manuela, Pedroso,Sofia, Martins,La Salete, Dias,Leonídio, Henriques,António Castro, Cabrita,António
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009
Resumo: Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis.
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spelling Tacrolimus: a forgotten agent in kidney transplant leukopeniaLeukopeniarenal transplantationtacrolimusLeukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis.Sociedade Portuguesa de Nefrologia2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009Portuguese Journal of Nephrology & Hypertension v.27 n.1 2013reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009Azevedo,PedroFreitas,CristinaSilva,HugoAguiar,PedroSantos,TeresaCabral,JoãoRocha,GuilhermeAlmeida,ManuelaPedroso,SofiaMartins,La SaleteDias,LeonídioHenriques,António CastroCabrita,Antónioinfo:eu-repo/semantics/openAccess2024-02-06T17:04:41Zoai:scielo:S0872-01692013000100009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:50.173498Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tacrolimus: a forgotten agent in kidney transplant leukopenia
title Tacrolimus: a forgotten agent in kidney transplant leukopenia
spellingShingle Tacrolimus: a forgotten agent in kidney transplant leukopenia
Azevedo,Pedro
Leukopenia
renal transplantation
tacrolimus
title_short Tacrolimus: a forgotten agent in kidney transplant leukopenia
title_full Tacrolimus: a forgotten agent in kidney transplant leukopenia
title_fullStr Tacrolimus: a forgotten agent in kidney transplant leukopenia
title_full_unstemmed Tacrolimus: a forgotten agent in kidney transplant leukopenia
title_sort Tacrolimus: a forgotten agent in kidney transplant leukopenia
author Azevedo,Pedro
author_facet Azevedo,Pedro
Freitas,Cristina
Silva,Hugo
Aguiar,Pedro
Santos,Teresa
Cabral,João
Rocha,Guilherme
Almeida,Manuela
Pedroso,Sofia
Martins,La Salete
Dias,Leonídio
Henriques,António Castro
Cabrita,António
author_role author
author2 Freitas,Cristina
Silva,Hugo
Aguiar,Pedro
Santos,Teresa
Cabral,João
Rocha,Guilherme
Almeida,Manuela
Pedroso,Sofia
Martins,La Salete
Dias,Leonídio
Henriques,António Castro
Cabrita,António
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Azevedo,Pedro
Freitas,Cristina
Silva,Hugo
Aguiar,Pedro
Santos,Teresa
Cabral,João
Rocha,Guilherme
Almeida,Manuela
Pedroso,Sofia
Martins,La Salete
Dias,Leonídio
Henriques,António Castro
Cabrita,António
dc.subject.por.fl_str_mv Leukopenia
renal transplantation
tacrolimus
topic Leukopenia
renal transplantation
tacrolimus
description Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.27 n.1 2013
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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