Tacrolimus: a forgotten agent in kidney transplant leukopenia
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009 |
Resumo: | Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis. |
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Tacrolimus: a forgotten agent in kidney transplant leukopeniaLeukopeniarenal transplantationtacrolimusLeukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis.Sociedade Portuguesa de Nefrologia2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009Portuguese Journal of Nephrology & Hypertension v.27 n.1 2013reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009Azevedo,PedroFreitas,CristinaSilva,HugoAguiar,PedroSantos,TeresaCabral,JoãoRocha,GuilhermeAlmeida,ManuelaPedroso,SofiaMartins,La SaleteDias,LeonídioHenriques,António CastroCabrita,Antónioinfo:eu-repo/semantics/openAccess2024-02-06T17:04:41Zoai:scielo:S0872-01692013000100009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:50.173498Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
title |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
spellingShingle |
Tacrolimus: a forgotten agent in kidney transplant leukopenia Azevedo,Pedro Leukopenia renal transplantation tacrolimus |
title_short |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
title_full |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
title_fullStr |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
title_full_unstemmed |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
title_sort |
Tacrolimus: a forgotten agent in kidney transplant leukopenia |
author |
Azevedo,Pedro |
author_facet |
Azevedo,Pedro Freitas,Cristina Silva,Hugo Aguiar,Pedro Santos,Teresa Cabral,João Rocha,Guilherme Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Henriques,António Castro Cabrita,António |
author_role |
author |
author2 |
Freitas,Cristina Silva,Hugo Aguiar,Pedro Santos,Teresa Cabral,João Rocha,Guilherme Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Henriques,António Castro Cabrita,António |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Azevedo,Pedro Freitas,Cristina Silva,Hugo Aguiar,Pedro Santos,Teresa Cabral,João Rocha,Guilherme Almeida,Manuela Pedroso,Sofia Martins,La Salete Dias,Leonídio Henriques,António Castro Cabrita,António |
dc.subject.por.fl_str_mv |
Leukopenia renal transplantation tacrolimus |
topic |
Leukopenia renal transplantation tacrolimus |
description |
Leukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing within seven months after renal transplant. After excluding other potential causes, tacrolimus was switched to cyclosporine, with recovery of white blood cell count. Based on the clinical report, the authors reviewed causes of post-transplant leukopenia, focusing on the diagnostic investigation. Early diagnosis and interventions are fundamental to improve prognosis. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000100009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.27 n.1 2013 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137278351638528 |