Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/105334 https://doi.org/10.3390/pharmaceutics13040491 |
Resumo: | Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed. |
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Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?leishmaniasisnanomaterialsimmunosensorsgenosensorsparasitic diseasesLeishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.MDPI2021-04-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105334http://hdl.handle.net/10316/105334https://doi.org/10.3390/pharmaceutics13040491eng1999-4923Jain, SonaSantana, WanessaDolabella, Silvio S.Santos, André L. S.Souto, Eliana B.Severino, Patríciainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-02-17T10:40:48Zoai:estudogeral.uc.pt:10316/105334Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:55.653581Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
title |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
spellingShingle |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? Jain, Sona leishmaniasis nanomaterials immunosensors genosensors parasitic diseases |
title_short |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
title_full |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
title_fullStr |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
title_full_unstemmed |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
title_sort |
Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania? |
author |
Jain, Sona |
author_facet |
Jain, Sona Santana, Wanessa Dolabella, Silvio S. Santos, André L. S. Souto, Eliana B. Severino, Patrícia |
author_role |
author |
author2 |
Santana, Wanessa Dolabella, Silvio S. Santos, André L. S. Souto, Eliana B. Severino, Patrícia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Jain, Sona Santana, Wanessa Dolabella, Silvio S. Santos, André L. S. Souto, Eliana B. Severino, Patrícia |
dc.subject.por.fl_str_mv |
leishmaniasis nanomaterials immunosensors genosensors parasitic diseases |
topic |
leishmaniasis nanomaterials immunosensors genosensors parasitic diseases |
description |
Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/105334 http://hdl.handle.net/10316/105334 https://doi.org/10.3390/pharmaceutics13040491 |
url |
http://hdl.handle.net/10316/105334 https://doi.org/10.3390/pharmaceutics13040491 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4923 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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