Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/5890 |
Resumo: | Diabetes mellitus (DM) is a pandemic metabolic disease that affects an enormous amount of males at a very early age. It is a leading cause of morbidity and mortality, in both developed and in developing countries. Type 2 diabetes mellitus (T2DM) is responsible for the vast majority of DM cases. It comprises individuals who present insulin resistance and relative insulin deficiency. Unlike type 1 diabetes mellitus (T1DM), the main triggering factor of T2DM seems to be the new lifestyle of modern societies rather than genetic factors. The process of production of viable spermatozoa is strictly regulated and dependent of several factors. Any alterations in this process may result in fertility problems in the male. The developing germ cells are dependent on the metabolic cooperation established with the Sertoli cells (SCs), being reliant on the lactate produced by these testicular somatic cells, as energy source. Of the various antidiabetics available in the market, a number of them have a direct action in the individual metabolic homeodynamics. However, its mechanisms of action are different and vary dependent on several factors (e.g. tissue or target cells). In this work, we evaluated the effect of two antidiabetic drugs, pioglitazone and metformin, in human Sertoli cell metabolism (hSCs). Our results suggest that, like metformin, pioglitazone may be a suitable antidiabetic drug for young men and those in reproductive age. These novel findings suggest a possible protective role of pioglitazone to male reproductive function. |
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Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male FertilityEfeito de Antidiabéticos em Células de Sertoli Humanas: Implicações Para a FertilidadeCélulas de SertoliEspermatogéneseInfertilidadeMetforminaMitocôndriaPioglitazonaDomínio/Área Científica::Ciências Médicas::Ciências BiomédicasDiabetes mellitus (DM) is a pandemic metabolic disease that affects an enormous amount of males at a very early age. It is a leading cause of morbidity and mortality, in both developed and in developing countries. Type 2 diabetes mellitus (T2DM) is responsible for the vast majority of DM cases. It comprises individuals who present insulin resistance and relative insulin deficiency. Unlike type 1 diabetes mellitus (T1DM), the main triggering factor of T2DM seems to be the new lifestyle of modern societies rather than genetic factors. The process of production of viable spermatozoa is strictly regulated and dependent of several factors. Any alterations in this process may result in fertility problems in the male. The developing germ cells are dependent on the metabolic cooperation established with the Sertoli cells (SCs), being reliant on the lactate produced by these testicular somatic cells, as energy source. Of the various antidiabetics available in the market, a number of them have a direct action in the individual metabolic homeodynamics. However, its mechanisms of action are different and vary dependent on several factors (e.g. tissue or target cells). In this work, we evaluated the effect of two antidiabetic drugs, pioglitazone and metformin, in human Sertoli cell metabolism (hSCs). Our results suggest that, like metformin, pioglitazone may be a suitable antidiabetic drug for young men and those in reproductive age. These novel findings suggest a possible protective role of pioglitazone to male reproductive function.A diabetes mellitus (DM) é uma doença metabólica que está a atingir proporções pandémicas, afetando um elevado número de homens numa idade muito jovem. É uma das principais causas de morbilidade e mortalidade em países desenvolvidos e em desenvolvimento. A diabetes mellitus tipo 2 (T2DM) é responsável pela grande maioria de casos de DM. Compreende indivíduos que apresentam resistência à insulina e uma relativa deficiência na secreção de insulina. Ao contrário da diabetes mellitus tipo 1 (T1DM), o principal fator para o desenvolvimento da doença parece ser o estilo de vida das sociedades modernas em vez de fatores genéticos. O processo de produção de espermatozóides viáveis é altamente regulado, dependente de diversos fatores, e qualquer alteração pode resultar em problemas de fertilidade no homem. Entre outros aspectos, as células germinativas são dependentes da cooperação metabólica que estabelecem com as células de Sertoli (SCs), que mostrou ser essencial para a ocorrência da espermatogénese. Dos diferentes antidiabéticos disponíveis no mercado, vários têm uma ação na homeodinâmica metabólica do indivíduo. Contudo, os seus mecanismos de ação são distintos e variam dependendo de diversos fatores (p. ex. tecido ou células alvo). Neste trabalho, avaliámos o efeito de dois antidiabéticos, a pioglitazona e a metformina, no metabolismo de células de Sertoli humanas (hSCs). Os nossos resultados sugerem que, tal como a metformina, a pioglitazona é um antidiabético adequado para homens em idade reprodutiva. Para além disso, os resultados obtidos neste trabalho levam-nos a sugerir um possível papel protetor da pioglitazona na função reprodutiva masculina.Alves, Marco Aurélio GouveiaOliveira, Pedro FontesAlves, Marco Aurélio GouveiauBibliorumOliveira, Maria João Carvalho Meneses2018-08-30T15:34:17Z2015-6-52015-07-022015-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.6/5890TID:201644924enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:44:05Zoai:ubibliorum.ubi.pt:10400.6/5890Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:46:44.399322Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility Efeito de Antidiabéticos em Células de Sertoli Humanas: Implicações Para a Fertilidade |
title |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
spellingShingle |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility Oliveira, Maria João Carvalho Meneses Células de Sertoli Espermatogénese Infertilidade Metformina Mitocôndria Pioglitazona Domínio/Área Científica::Ciências Médicas::Ciências Biomédicas |
title_short |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
title_full |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
title_fullStr |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
title_full_unstemmed |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
title_sort |
Effect of Antidiabetic Drugs in Human Sertoli Cells: Implications for Male Fertility |
author |
Oliveira, Maria João Carvalho Meneses |
author_facet |
Oliveira, Maria João Carvalho Meneses |
author_role |
author |
dc.contributor.none.fl_str_mv |
Alves, Marco Aurélio Gouveia Oliveira, Pedro Fontes Alves, Marco Aurélio Gouveia uBibliorum |
dc.contributor.author.fl_str_mv |
Oliveira, Maria João Carvalho Meneses |
dc.subject.por.fl_str_mv |
Células de Sertoli Espermatogénese Infertilidade Metformina Mitocôndria Pioglitazona Domínio/Área Científica::Ciências Médicas::Ciências Biomédicas |
topic |
Células de Sertoli Espermatogénese Infertilidade Metformina Mitocôndria Pioglitazona Domínio/Área Científica::Ciências Médicas::Ciências Biomédicas |
description |
Diabetes mellitus (DM) is a pandemic metabolic disease that affects an enormous amount of males at a very early age. It is a leading cause of morbidity and mortality, in both developed and in developing countries. Type 2 diabetes mellitus (T2DM) is responsible for the vast majority of DM cases. It comprises individuals who present insulin resistance and relative insulin deficiency. Unlike type 1 diabetes mellitus (T1DM), the main triggering factor of T2DM seems to be the new lifestyle of modern societies rather than genetic factors. The process of production of viable spermatozoa is strictly regulated and dependent of several factors. Any alterations in this process may result in fertility problems in the male. The developing germ cells are dependent on the metabolic cooperation established with the Sertoli cells (SCs), being reliant on the lactate produced by these testicular somatic cells, as energy source. Of the various antidiabetics available in the market, a number of them have a direct action in the individual metabolic homeodynamics. However, its mechanisms of action are different and vary dependent on several factors (e.g. tissue or target cells). In this work, we evaluated the effect of two antidiabetic drugs, pioglitazone and metformin, in human Sertoli cell metabolism (hSCs). Our results suggest that, like metformin, pioglitazone may be a suitable antidiabetic drug for young men and those in reproductive age. These novel findings suggest a possible protective role of pioglitazone to male reproductive function. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-6-5 2015-07-02 2015-07-02T00:00:00Z 2018-08-30T15:34:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
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http://hdl.handle.net/10400.6/5890 TID:201644924 |
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http://hdl.handle.net/10400.6/5890 |
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TID:201644924 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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