A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma

Detalhes bibliográficos
Autor(a) principal: Santos,Ana Luísa
Data de Publicação: 2020
Outros Autores: Pereira,Vítor Magno, Coelho,Rosa, Gaspar,Rui, Cardoso,Hélder, Lopes,Joanne, Macedo,Guilherme
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009
Resumo: The authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis.
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spelling A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell CarcinomaNeuroendocrine carcinomaLiver metástasesLiver biopsyLiver failureHepatic encephalopathyThe authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis.Sociedade Portuguesa de Gastrenterologia2020-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009GE-Portuguese Journal of Gastroenterology v.27 n.3 2020reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009Santos,Ana LuísaPereira,Vítor MagnoCoelho,RosaGaspar,RuiCardoso,HélderLopes,JoanneMacedo,Guilhermeinfo:eu-repo/semantics/openAccess2024-02-06T17:34:04Zoai:scielo:S2341-45452020000300009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:36:11.569509Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
title A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
spellingShingle A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
Santos,Ana Luísa
Neuroendocrine carcinoma
Liver metástases
Liver biopsy
Liver failure
Hepatic encephalopathy
title_short A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
title_full A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
title_fullStr A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
title_full_unstemmed A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
title_sort A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
author Santos,Ana Luísa
author_facet Santos,Ana Luísa
Pereira,Vítor Magno
Coelho,Rosa
Gaspar,Rui
Cardoso,Hélder
Lopes,Joanne
Macedo,Guilherme
author_role author
author2 Pereira,Vítor Magno
Coelho,Rosa
Gaspar,Rui
Cardoso,Hélder
Lopes,Joanne
Macedo,Guilherme
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos,Ana Luísa
Pereira,Vítor Magno
Coelho,Rosa
Gaspar,Rui
Cardoso,Hélder
Lopes,Joanne
Macedo,Guilherme
dc.subject.por.fl_str_mv Neuroendocrine carcinoma
Liver metástases
Liver biopsy
Liver failure
Hepatic encephalopathy
topic Neuroendocrine carcinoma
Liver metástases
Liver biopsy
Liver failure
Hepatic encephalopathy
description The authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
publisher.none.fl_str_mv Sociedade Portuguesa de Gastrenterologia
dc.source.none.fl_str_mv GE-Portuguese Journal of Gastroenterology v.27 n.3 2020
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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