A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009 |
Resumo: | The authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis. |
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A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell CarcinomaNeuroendocrine carcinomaLiver metástasesLiver biopsyLiver failureHepatic encephalopathyThe authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis.Sociedade Portuguesa de Gastrenterologia2020-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009GE-Portuguese Journal of Gastroenterology v.27 n.3 2020reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009Santos,Ana LuísaPereira,Vítor MagnoCoelho,RosaGaspar,RuiCardoso,HélderLopes,JoanneMacedo,Guilhermeinfo:eu-repo/semantics/openAccess2024-02-06T17:34:04Zoai:scielo:S2341-45452020000300009Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:36:11.569509Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
title |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
spellingShingle |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma Santos,Ana Luísa Neuroendocrine carcinoma Liver metástases Liver biopsy Liver failure Hepatic encephalopathy |
title_short |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
title_full |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
title_fullStr |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
title_full_unstemmed |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
title_sort |
A Rare Cause of Acute Liver Failure: Diffuse Liver Metastization of Merkel Cell Carcinoma |
author |
Santos,Ana Luísa |
author_facet |
Santos,Ana Luísa Pereira,Vítor Magno Coelho,Rosa Gaspar,Rui Cardoso,Hélder Lopes,Joanne Macedo,Guilherme |
author_role |
author |
author2 |
Pereira,Vítor Magno Coelho,Rosa Gaspar,Rui Cardoso,Hélder Lopes,Joanne Macedo,Guilherme |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Ana Luísa Pereira,Vítor Magno Coelho,Rosa Gaspar,Rui Cardoso,Hélder Lopes,Joanne Macedo,Guilherme |
dc.subject.por.fl_str_mv |
Neuroendocrine carcinoma Liver metástases Liver biopsy Liver failure Hepatic encephalopathy |
topic |
Neuroendocrine carcinoma Liver metástases Liver biopsy Liver failure Hepatic encephalopathy |
description |
The authors describe a case of a 76-year-old male with a medical history of Merkel cell carcinoma (MCC) of the right lower eyelid. He was admitted to the emergency department due to abdominal pain in the right hypochondrium, nauseas, asthenia, and choluria with 3 days of evolution. Biochemical liver workup revealed a cytocholestase pattern as well as a prolonged prothrombin time. After admission, the patient developed hepatic encephalopathy, and a clinical and analytical worsening was observed. Abdominal ultrasound showed a reduction in the caliber of the hepatic veins, in apparent relation to a parenchymal compression. Liver biopsy was performed and showed an extensive infiltration of the hepatic parenchyma by a solid neoplasm, which, upon immunohistochemical study, was compatible with a diffuse metastization of a MCC. We report this clinical case due to its rarity of presentation and to show the important role of liver biopsy in cases of acute hepatitis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452020000300009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
dc.source.none.fl_str_mv |
GE-Portuguese Journal of Gastroenterology v.27 n.3 2020 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137414195707904 |