Muscle glycome in idiopathic inflammatory myopathies

Detalhes bibliográficos
Autor(a) principal: Campar, Ana
Data de Publicação: 2023
Outros Autores: Alves, Inês, Santos-Pereira, Beatriz, Nogueira, Rafaela, Pinto, Miguel Mendonça, Vasconcelos, Carlos, Pinho, Salomé S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/161343
Resumo: Funding: Supported by the Portugal 2020 Partnership Agreement’s Norte Portugal Regional Programme (NORTE 2020) (project NORTE-01-0145-FEDER-000029 ), Fundo Europeu de Desenvolvimento Regional (FEDER) funds from the Compete2020 Science, Technology, and Innovation Operational Programme (POCI), and the Portuguese Foundation for Science and Technology (FCT) (projects POCI-01/0145-FEDER-016601 and POCI-01-0145-FEDER-028772 ). A.C. work was supported by the Portuguese Society of Internal Medicine’s Group for Study of Autoimmune Diseases ( NEDAI ). I.A. and S.S.P. were also funded by Clinical Research in Autoimmunity prize (supported by National Medical Association in Autoimmunity (NEDAI) and National Society of Internal Medicine (SPMI)) and Pfizer prize (supported by Pfizer and Society of Medical Sciences of Lisbon ). Publisher Copyright: © 2023 The Author(s)
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spelling Muscle glycome in idiopathic inflammatory myopathiesImpact in IL-6 production and disease prognosisDiseaseGlycobiologyGlycomicsHealth sciencesGeneralFunding: Supported by the Portugal 2020 Partnership Agreement’s Norte Portugal Regional Programme (NORTE 2020) (project NORTE-01-0145-FEDER-000029 ), Fundo Europeu de Desenvolvimento Regional (FEDER) funds from the Compete2020 Science, Technology, and Innovation Operational Programme (POCI), and the Portuguese Foundation for Science and Technology (FCT) (projects POCI-01/0145-FEDER-016601 and POCI-01-0145-FEDER-028772 ). A.C. work was supported by the Portuguese Society of Internal Medicine’s Group for Study of Autoimmune Diseases ( NEDAI ). I.A. and S.S.P. were also funded by Clinical Research in Autoimmunity prize (supported by National Medical Association in Autoimmunity (NEDAI) and National Society of Internal Medicine (SPMI)) and Pfizer prize (supported by Pfizer and Society of Medical Sciences of Lisbon ). Publisher Copyright: © 2023 The Author(s)Idiopathic inflammatory myopathies (IIM) are a group of chronic autoimmune diseases mainly affecting proximal muscles. Absence of meaningful prognostic factors in IIM has hindered new therapies development. Glycans are essential molecules that regulate immunological tolerance and consequently the onset of autoreactive immune response. We showed that muscle biopsies from patients with IIM revealed a deficiency in the glycosylation pathway resulting in loss of branched N-glycans. At diagnosis, this glycosignature predicted disease relapse and treatment refractoriness. Peripheral CD4+ T cells from active-disease patients shown a deficiency in branched N-glycans, linked to increased IL-6 production. Glycan supplementation, restoring homeostatic glycosylation profile, led to a decrease in IL-6 levels. This study highlights the biological and clinical importance of glycosylation in IIM immunopathogenesis, providing a potential mechanism for IL-6 production. This pinpoints muscle glycome as promising biomarker for personalized follow-up and a potential target for new therapies in a patients’ subgroup with an ominous evolution.DQ - Departamento de QuímicaRUNCampar, AnaAlves, InêsSantos-Pereira, BeatrizNogueira, RafaelaPinto, Miguel MendonçaVasconcelos, CarlosPinho, Salomé S.2023-12-15T22:46:44Z2023-07-212023-07-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/161343engCampar, A., Alves, I., Santos-Pereira, B., Nogueira, R., Pinto, M. M., Vasconcelos, C., & Pinho, S. S. (2023). Muscle glycome in idiopathic inflammatory myopathies: Impact in IL-6 production and disease prognosis. ISCIENCE, 26(7), [107172]. https://doi.org/10.1016/j.isci.2023.1071722589-0042PURE: 75760399https://doi.org/10.1016/j.isci.2023.107172info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:44:15Zoai:run.unl.pt:10362/161343Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:29.904063Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Muscle glycome in idiopathic inflammatory myopathies
Impact in IL-6 production and disease prognosis
title Muscle glycome in idiopathic inflammatory myopathies
spellingShingle Muscle glycome in idiopathic inflammatory myopathies
Campar, Ana
Disease
Glycobiology
Glycomics
Health sciences
General
title_short Muscle glycome in idiopathic inflammatory myopathies
title_full Muscle glycome in idiopathic inflammatory myopathies
title_fullStr Muscle glycome in idiopathic inflammatory myopathies
title_full_unstemmed Muscle glycome in idiopathic inflammatory myopathies
title_sort Muscle glycome in idiopathic inflammatory myopathies
author Campar, Ana
author_facet Campar, Ana
Alves, Inês
Santos-Pereira, Beatriz
Nogueira, Rafaela
Pinto, Miguel Mendonça
Vasconcelos, Carlos
Pinho, Salomé S.
author_role author
author2 Alves, Inês
Santos-Pereira, Beatriz
Nogueira, Rafaela
Pinto, Miguel Mendonça
Vasconcelos, Carlos
Pinho, Salomé S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Campar, Ana
Alves, Inês
Santos-Pereira, Beatriz
Nogueira, Rafaela
Pinto, Miguel Mendonça
Vasconcelos, Carlos
Pinho, Salomé S.
dc.subject.por.fl_str_mv Disease
Glycobiology
Glycomics
Health sciences
General
topic Disease
Glycobiology
Glycomics
Health sciences
General
description Funding: Supported by the Portugal 2020 Partnership Agreement’s Norte Portugal Regional Programme (NORTE 2020) (project NORTE-01-0145-FEDER-000029 ), Fundo Europeu de Desenvolvimento Regional (FEDER) funds from the Compete2020 Science, Technology, and Innovation Operational Programme (POCI), and the Portuguese Foundation for Science and Technology (FCT) (projects POCI-01/0145-FEDER-016601 and POCI-01-0145-FEDER-028772 ). A.C. work was supported by the Portuguese Society of Internal Medicine’s Group for Study of Autoimmune Diseases ( NEDAI ). I.A. and S.S.P. were also funded by Clinical Research in Autoimmunity prize (supported by National Medical Association in Autoimmunity (NEDAI) and National Society of Internal Medicine (SPMI)) and Pfizer prize (supported by Pfizer and Society of Medical Sciences of Lisbon ). Publisher Copyright: © 2023 The Author(s)
publishDate 2023
dc.date.none.fl_str_mv 2023-12-15T22:46:44Z
2023-07-21
2023-07-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/161343
url http://hdl.handle.net/10362/161343
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Campar, A., Alves, I., Santos-Pereira, B., Nogueira, R., Pinto, M. M., Vasconcelos, C., & Pinho, S. S. (2023). Muscle glycome in idiopathic inflammatory myopathies: Impact in IL-6 production and disease prognosis. ISCIENCE, 26(7), [107172]. https://doi.org/10.1016/j.isci.2023.107172
2589-0042
PURE: 75760399
https://doi.org/10.1016/j.isci.2023.107172
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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