Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines

Detalhes bibliográficos
Autor(a) principal: Francisco, Carla S.
Data de Publicação: 2012
Outros Autores: Rodrigues, L. R., Cerqueira, N. M. F. S. A., Campos, Ana M. F. Oliveira, Rodrigues, Lígia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/16410
Resumo: The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship.
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spelling Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell linesBenzofurocoumarins;Benzopsoralen analoguesAntitumour activityDockingComputational studiesAntitumor activityScience & TechnologyThe synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship.FCT and FEDER, for National NMR Network (Bruker Avance II 400), REEQ/630/QUI/2005 (LC/MS instrument) and the PhD grant (SFRH/BD/48636/2008).ElsevierUniversidade do MinhoFrancisco, Carla S.Rodrigues, L. R.Cerqueira, N. M. F. S. A.Campos, Ana M. F. OliveiraRodrigues, Lígia M.2012-012012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16410eng0223-523410.1016/j.ejmech.2011.11.00522119152http://www.elsevier.com/locate/ejmechinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:05Zoai:repositorium.sdum.uminho.pt:1822/16410Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:56.150374Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
title Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
spellingShingle Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
Francisco, Carla S.
Benzofurocoumarins;
Benzopsoralen analogues
Antitumour activity
Docking
Computational studies
Antitumor activity
Science & Technology
title_short Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
title_full Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
title_fullStr Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
title_full_unstemmed Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
title_sort Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
author Francisco, Carla S.
author_facet Francisco, Carla S.
Rodrigues, L. R.
Cerqueira, N. M. F. S. A.
Campos, Ana M. F. Oliveira
Rodrigues, Lígia M.
author_role author
author2 Rodrigues, L. R.
Cerqueira, N. M. F. S. A.
Campos, Ana M. F. Oliveira
Rodrigues, Lígia M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Francisco, Carla S.
Rodrigues, L. R.
Cerqueira, N. M. F. S. A.
Campos, Ana M. F. Oliveira
Rodrigues, Lígia M.
dc.subject.por.fl_str_mv Benzofurocoumarins;
Benzopsoralen analogues
Antitumour activity
Docking
Computational studies
Antitumor activity
Science & Technology
topic Benzofurocoumarins;
Benzopsoralen analogues
Antitumour activity
Docking
Computational studies
Antitumor activity
Science & Technology
description The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/16410
url http://hdl.handle.net/1822/16410
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0223-5234
10.1016/j.ejmech.2011.11.005
22119152
http://www.elsevier.com/locate/ejmech
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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