Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

Detalhes bibliográficos
Autor(a) principal: Oliveira, Ana M. A. G.
Data de Publicação: 2006
Outros Autores: Campos, Ana M. F. Oliveira, Raposo, M. Manuela M., Machado, António E. H., Puapairoj, Prapawadee, Pedro, Madalena, Nascimento, Maria São José, Portela, César, Afonso, Carlos A. M., Pinto, Madalena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/5168
Resumo: Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.
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spelling Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studiesFurocoumarinsBenzopsoralensAntitumorComputational studiesScience & TechnologyEight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.For financial support from Fundação para a Ciência e Tecnologia, Portugal (I&D no. 226/9 and to CQ-UM), POCTI and FEDER; Ph.D. grants from FCT: Ana M.A.G. Oliveira (PRAXIS XXI/BD/19707/99), Madalena Pedro (SFRH/BD/1456/2000) and César Portela (SFRH/BD/3036/2000). For financial support and research grants to FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais) and CNPq (Conselho Nacional do Desenvolvimento Científico e Tecnológico, Brazil). The authors thank National Cancer Institute, Bethesda, MD (USA) for kindly providing the tumor cell lines and Elisa Pinto for obtaining 1H-NMR and 13C-NMR spectra and elemental analyses.POCTI.ElsevierUniversidade do MinhoOliveira, Ana M. A. G.Campos, Ana M. F. OliveiraRaposo, M. Manuela M.Machado, António E. H.Puapairoj, PrapawadeePedro, MadalenaNascimento, Maria São JoséPortela, CésarAfonso, Carlos A. M.Pinto, Madalena2006-032006-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/5168engOliveira, A. M. A. G., Raposo, M. M. M., Oliveira-Campos, A. M. F., Machado, A. E. H., Puapairoj, P., Pedro, M., . . . Pinto, M. (2006). Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies. European Journal of Medicinal Chemistry, 41(3), 367-372. doi: https://doi.org/10.1016/j.ejmech.2005.10.0160223-543410.1016/j.ejmech.2005.10.01616439037https://www.sciencedirect.com/science/article/pii/S0223523405003090info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:56:35Zoai:repositorium.sdum.uminho.pt:1822/5168Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:56:35Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
title Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
spellingShingle Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
Oliveira, Ana M. A. G.
Furocoumarins
Benzopsoralens
Antitumor
Computational studies
Science & Technology
title_short Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
title_full Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
title_fullStr Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
title_full_unstemmed Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
title_sort Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
author Oliveira, Ana M. A. G.
author_facet Oliveira, Ana M. A. G.
Campos, Ana M. F. Oliveira
Raposo, M. Manuela M.
Machado, António E. H.
Puapairoj, Prapawadee
Pedro, Madalena
Nascimento, Maria São José
Portela, César
Afonso, Carlos A. M.
Pinto, Madalena
author_role author
author2 Campos, Ana M. F. Oliveira
Raposo, M. Manuela M.
Machado, António E. H.
Puapairoj, Prapawadee
Pedro, Madalena
Nascimento, Maria São José
Portela, César
Afonso, Carlos A. M.
Pinto, Madalena
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Ana M. A. G.
Campos, Ana M. F. Oliveira
Raposo, M. Manuela M.
Machado, António E. H.
Puapairoj, Prapawadee
Pedro, Madalena
Nascimento, Maria São José
Portela, César
Afonso, Carlos A. M.
Pinto, Madalena
dc.subject.por.fl_str_mv Furocoumarins
Benzopsoralens
Antitumor
Computational studies
Science & Technology
topic Furocoumarins
Benzopsoralens
Antitumor
Computational studies
Science & Technology
description Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human turner cell lines representing different tumor types, MCF-7 (breast cancer), NCI-14460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofur-ocournarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the structure with the antitumor activity. This work provides supplementary information that could allow the development of new psoralen analogues with this type of biological activity.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
2006-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/5168
url http://hdl.handle.net/1822/5168
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira, A. M. A. G., Raposo, M. M. M., Oliveira-Campos, A. M. F., Machado, A. E. H., Puapairoj, P., Pedro, M., . . . Pinto, M. (2006). Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies. European Journal of Medicinal Chemistry, 41(3), 367-372. doi: https://doi.org/10.1016/j.ejmech.2005.10.016
0223-5434
10.1016/j.ejmech.2005.10.016
16439037
https://www.sciencedirect.com/science/article/pii/S0223523405003090
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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