Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing

Detalhes bibliográficos
Autor(a) principal: Barvitenko, Nadezhda
Data de Publicação: 2021
Outros Autores: Aslam, Muhammad, Lawen, Alfons, Saldanha, Carlota, Skverchinskaya, Elisaveta, Uras, Giuseppe, Manca, Alessia, Pantaleo, Antonella
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50062
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensingActin cortexActin polymerizationApoptosisCell volumeMechanosensorsMigrationNon-muscle myosin IIProliferationShrinkageSwelling© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Changes in plasma membrane curvature and intracellular ionic strength are two key features of cell volume perturbations. In this hypothesis we present a model of the responsible molecular apparatus which is assembled of two molecular motors [non-muscle myosin II (NMMII) and protrusive actin polymerization], a spring [a complex between the plasma membrane (PM) and the submembrane actin-based cytoskeleton (smACSK) which behaves like a viscoelastic solid] and the associated signaling proteins. We hypothesize that this apparatus senses changes in both the plasma membrane curvature and the ionic strength and in turn activates signaling pathways responsible for regulatory volume increase (RVI) and regulatory volume decrease (RVD). During cell volume changes hydrostatic pressure (HP) changes drive alterations in the cell membrane curvature. HP difference has opposite directions in swelling versus shrinkage, thus allowing distinction between them. By analogy with actomyosin contractility that appears to sense stiffness of the extracellular matrix we propose that NMMII and actin polymerization can actively probe the transmembrane gradient in HP. Furthermore, NMMII and protein-protein interactions in the actin cortex are sensitive to ionic strength. Emerging data on direct binding to and regulating activities of transmembrane mechanosensors by NMMII and actin cortex provide routes for signal transduction from transmembrane mechanosensors to cell volume regulatory mechanisms.MDPIRepositório da Universidade de LisboaBarvitenko, NadezhdaAslam, MuhammadLawen, AlfonsSaldanha, CarlotaSkverchinskaya, ElisavetaUras, GiuseppeManca, AlessiaPantaleo, Antonella2021-10-29T14:35:53Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50062engInt J Mol Sci. 2021 Jul 26;22(15):79671661-659610.3390/ijms221579671422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-14T15:37:11ZPortal AgregadorONG
dc.title.none.fl_str_mv Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
title Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
spellingShingle Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
Barvitenko, Nadezhda
Actin cortex
Actin polymerization
Apoptosis
Cell volume
Mechanosensors
Migration
Non-muscle myosin II
Proliferation
Shrinkage
Swelling
title_short Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
title_full Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
title_fullStr Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
title_full_unstemmed Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
title_sort Two motors and one spring: hypothetic roles of non-muscle Myosin II and submembrane actin-based Cytoskeleton in cell volume sensing
author Barvitenko, Nadezhda
author_facet Barvitenko, Nadezhda
Aslam, Muhammad
Lawen, Alfons
Saldanha, Carlota
Skverchinskaya, Elisaveta
Uras, Giuseppe
Manca, Alessia
Pantaleo, Antonella
author_role author
author2 Aslam, Muhammad
Lawen, Alfons
Saldanha, Carlota
Skverchinskaya, Elisaveta
Uras, Giuseppe
Manca, Alessia
Pantaleo, Antonella
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Barvitenko, Nadezhda
Aslam, Muhammad
Lawen, Alfons
Saldanha, Carlota
Skverchinskaya, Elisaveta
Uras, Giuseppe
Manca, Alessia
Pantaleo, Antonella
dc.subject.por.fl_str_mv Actin cortex
Actin polymerization
Apoptosis
Cell volume
Mechanosensors
Migration
Non-muscle myosin II
Proliferation
Shrinkage
Swelling
topic Actin cortex
Actin polymerization
Apoptosis
Cell volume
Mechanosensors
Migration
Non-muscle myosin II
Proliferation
Shrinkage
Swelling
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-10-29T14:35:53Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50062
url http://hdl.handle.net/10451/50062
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2021 Jul 26;22(15):7967
1661-6596
10.3390/ijms22157967
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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