Uncovering the interactions between deleterious mutations, divergent selection and migration

Detalhes bibliográficos
Autor(a) principal: Caneira, Gonçalo Abrantes
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53747
Resumo: Tese de mestrado, Biologia Evolutiva e do Desenvolvimento, Universidade de Lisboa, Faculdade de Ciências, 2022
id RCAP_de524f07eb7e7468d5ccfdde1fbdd684
oai_identifier_str oai:repositorio.ul.pt:10451/53747
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Uncovering the interactions between deleterious mutations, divergent selection and migrationBackground SelectionAssociative OverdominanceMutações DeletériasFluxo GénicoSeleção DivergenteTeses de mestrado - 2022Departamento de Biologia AnimalTese de mestrado, Biologia Evolutiva e do Desenvolvimento, Universidade de Lisboa, Faculdade de Ciências, 2022Background selection (BGS) and associative overdominance (AOD) are processes describing the effect of removal of deleterious mutations on linked neutral variation. Mathematical modelling and sim ulations predict that, in comparison to neutrality, BGS leads to reduced genetic diversity while AOD leads to an increase, with greater effects in low recombining regions. However, little is known about the impact of migration and hemizygosity (X-chromosomes or haplodiploid sex-determining system). Moreover, studies about divergent selection with migration usually ignore deleterious mutations. The objective of this thesis was to use simulations to predict genomic patterns of diversity and differenti ation resulting from the interaction between deleterious mutations, divergent selection, migration and haplodiploidy. We used forward-in-time simulations under an isolation-with-migration model with two populations, investigating variation in dominance, migration rate, recombination rate, and selective co efficients. To assess the impact of interactions between deleterious mutations and divergent selection, we performed simulations according to the demographic history from two sister species of haplodiploid Neodiprion sawflies to simulate a real-life based model. We found that the pattern of variation of the ratio of within population nucleotide diversity over its neutral expectation (π/πneutral) as a function of deleterious selective coefficient is only slightly influenced by gene flow. However, the ratio of between population differentiation (FST /FSTneutral) becomes closer to 1 as migration rate increases, suggesting a migration threshold above which linked selection has no effect on FST . We found a lower migration threshold for genomic regions under BGS than AOD. For fully and partially recessive deleterious mutations we discovered a transition between AOD and BGS as selective coefficients increased, both with and without migration. Finally, we introduce predictions for the genomic patterns of haplodiploid populations experiencing divergent selection and asymmetric gene flow.Sousa, Vítor Martins Conde e, 1981-Repositório da Universidade de LisboaCaneira, Gonçalo Abrantes2024-02-17T01:32:01Z202220222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/53747enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-19T01:18:03Zoai:repositorio.ul.pt:10451/53747Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:41.523659Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Uncovering the interactions between deleterious mutations, divergent selection and migration
title Uncovering the interactions between deleterious mutations, divergent selection and migration
spellingShingle Uncovering the interactions between deleterious mutations, divergent selection and migration
Caneira, Gonçalo Abrantes
Background Selection
Associative Overdominance
Mutações Deletérias
Fluxo Génico
Seleção Divergente
Teses de mestrado - 2022
Departamento de Biologia Animal
title_short Uncovering the interactions between deleterious mutations, divergent selection and migration
title_full Uncovering the interactions between deleterious mutations, divergent selection and migration
title_fullStr Uncovering the interactions between deleterious mutations, divergent selection and migration
title_full_unstemmed Uncovering the interactions between deleterious mutations, divergent selection and migration
title_sort Uncovering the interactions between deleterious mutations, divergent selection and migration
author Caneira, Gonçalo Abrantes
author_facet Caneira, Gonçalo Abrantes
author_role author
dc.contributor.none.fl_str_mv Sousa, Vítor Martins Conde e, 1981-
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Caneira, Gonçalo Abrantes
dc.subject.por.fl_str_mv Background Selection
Associative Overdominance
Mutações Deletérias
Fluxo Génico
Seleção Divergente
Teses de mestrado - 2022
Departamento de Biologia Animal
topic Background Selection
Associative Overdominance
Mutações Deletérias
Fluxo Génico
Seleção Divergente
Teses de mestrado - 2022
Departamento de Biologia Animal
description Tese de mestrado, Biologia Evolutiva e do Desenvolvimento, Universidade de Lisboa, Faculdade de Ciências, 2022
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022-01-01T00:00:00Z
2024-02-17T01:32:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53747
url http://hdl.handle.net/10451/53747
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134598045630464

Registros relacionados