C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia

Detalhes bibliográficos
Autor(a) principal: Gomes, A
Data de Publicação: 2024
Outros Autores: Ribeiro, R, Froes, F, Mergulhão, P, Gonçalves Pereira, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/52903
Resumo: Background and objective Community-acquired pneumonia (CAP) is a prevalent and life-threatening infection that causes significant morbidity and mortality. Biomarkers, such as C-reactive protein (CRP), can help to diagnose, monitor, and prognose patients with this condition. This study aimed to analyze the disease course, the CRP peak concentration, its relationship with prognosis, and its variation in hospitalized patients with pneumococcal CAP. Methodology This study included 797 patients diagnosed with pneumococcal CAP and admitted over four years to four different Portuguese hospitals, either to the ICU or the general ward. Results Although CRP peak concentration was not a good predictor of overall hospital mortality, higher peak concentration in older patients (>60 years) was associated with a dismal hospital prognosis. In contrast, younger patients who survived hospital discharge had a non-significant higher peak CRP concentration. A faster time until CRP decreased to at least half of its peak value also correlated with favorable outcomes after adjusting for age and bacteremia [failure to achieve a 50% decrease was associated with an adjusted hazard ratio (HR) for hospital mortality of 6.45; 95% confidence interval (CI): 4.30-9.69]. Conclusions Based on our findings, CRP may be a useful biomarker in the hospital setting for diagnosing and monitoring patients with pneumococcal CAP. Clinicians must be aware of its unique properties, clinical applications, and varying behaviors according to patient age groups.
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spelling C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal PneumoniaPneumonia PneumocócicaProteína C-ReativaPneumonia, PneumococcalC-Reactive ProteinBackground and objective Community-acquired pneumonia (CAP) is a prevalent and life-threatening infection that causes significant morbidity and mortality. Biomarkers, such as C-reactive protein (CRP), can help to diagnose, monitor, and prognose patients with this condition. This study aimed to analyze the disease course, the CRP peak concentration, its relationship with prognosis, and its variation in hospitalized patients with pneumococcal CAP. Methodology This study included 797 patients diagnosed with pneumococcal CAP and admitted over four years to four different Portuguese hospitals, either to the ICU or the general ward. Results Although CRP peak concentration was not a good predictor of overall hospital mortality, higher peak concentration in older patients (>60 years) was associated with a dismal hospital prognosis. In contrast, younger patients who survived hospital discharge had a non-significant higher peak CRP concentration. A faster time until CRP decreased to at least half of its peak value also correlated with favorable outcomes after adjusting for age and bacteremia [failure to achieve a 50% decrease was associated with an adjusted hazard ratio (HR) for hospital mortality of 6.45; 95% confidence interval (CI): 4.30-9.69]. Conclusions Based on our findings, CRP may be a useful biomarker in the hospital setting for diagnosing and monitoring patients with pneumococcal CAP. Clinicians must be aware of its unique properties, clinical applications, and varying behaviors according to patient age groups.Repositório ComumGomes, ARibeiro, RFroes, FMergulhão, PGonçalves Pereira, J2024-11-25T23:00:13Z20242024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/52903engCureus. 2024 Oct 22;16(10):e72112.10.7759/cureus.72112info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T07:34:31Zoai:comum.rcaap.pt:10400.26/52903Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T07:34:31Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
title C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
spellingShingle C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
Gomes, A
Pneumonia Pneumocócica
Proteína C-Reativa
Pneumonia, Pneumococcal
C-Reactive Protein
title_short C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
title_full C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
title_fullStr C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
title_full_unstemmed C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
title_sort C-reactive Protein Variation and Its Usefulness in the Prognostication and Monitoring of Patients With Pneumococcal Pneumonia
author Gomes, A
author_facet Gomes, A
Ribeiro, R
Froes, F
Mergulhão, P
Gonçalves Pereira, J
author_role author
author2 Ribeiro, R
Froes, F
Mergulhão, P
Gonçalves Pereira, J
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Gomes, A
Ribeiro, R
Froes, F
Mergulhão, P
Gonçalves Pereira, J
dc.subject.por.fl_str_mv Pneumonia Pneumocócica
Proteína C-Reativa
Pneumonia, Pneumococcal
C-Reactive Protein
topic Pneumonia Pneumocócica
Proteína C-Reativa
Pneumonia, Pneumococcal
C-Reactive Protein
description Background and objective Community-acquired pneumonia (CAP) is a prevalent and life-threatening infection that causes significant morbidity and mortality. Biomarkers, such as C-reactive protein (CRP), can help to diagnose, monitor, and prognose patients with this condition. This study aimed to analyze the disease course, the CRP peak concentration, its relationship with prognosis, and its variation in hospitalized patients with pneumococcal CAP. Methodology This study included 797 patients diagnosed with pneumococcal CAP and admitted over four years to four different Portuguese hospitals, either to the ICU or the general ward. Results Although CRP peak concentration was not a good predictor of overall hospital mortality, higher peak concentration in older patients (>60 years) was associated with a dismal hospital prognosis. In contrast, younger patients who survived hospital discharge had a non-significant higher peak CRP concentration. A faster time until CRP decreased to at least half of its peak value also correlated with favorable outcomes after adjusting for age and bacteremia [failure to achieve a 50% decrease was associated with an adjusted hazard ratio (HR) for hospital mortality of 6.45; 95% confidence interval (CI): 4.30-9.69]. Conclusions Based on our findings, CRP may be a useful biomarker in the hospital setting for diagnosing and monitoring patients with pneumococcal CAP. Clinicians must be aware of its unique properties, clinical applications, and varying behaviors according to patient age groups.
publishDate 2024
dc.date.none.fl_str_mv 2024-11-25T23:00:13Z
2024
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/52903
url http://hdl.handle.net/10400.26/52903
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cureus. 2024 Oct 22;16(10):e72112.
10.7759/cureus.72112
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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