A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

Detalhes bibliográficos
Autor(a) principal: Santos, Clementina M.M.
Data de Publicação: 2018
Outros Autores: Freitas, Marisa, Fernandes, Eduarda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/18353
Resumo: α-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of α-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.
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spelling A comprehensive review on xanthone derivatives as α-glucosidase inhibitorsDiabetesa-GlucosidaseInhibitionQSARXanthoneα-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of α-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.This work received financial support from the European Union (FEDER funds POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) under the Partnership Agreement PT2020 UID/QUI/50006/2013; FCT UID/QUI/00062/2013, and “Programa Operacional Competitividade e Internacionalização” (COMPETE) (POCI- 01-0145-FEDER-029241), and under the framework of QREN (NORTE-01-0145-FEDER-000024). Thanks are also due to Faculdade de Farmácia da Universidade do Porto and Instituto Politécnico de Bragança.Elsevier MassonBiblioteca Digital do IPBSantos, Clementina M.M.Freitas, MarisaFernandes, Eduarda2019-01-09T11:11:43Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/18353engSantos, Clementina M.M.; Freitas, Marisa; Fernandes, Eduarda (2018). A comprehensive review on xanthone derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry. ISSN 0223-5234. 157, p. 1460-14790223-523410.1016/j.ejmech.2018.07.073info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:42:07Zoai:bibliotecadigital.ipb.pt:10198/18353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:08:37.303097Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
title A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
spellingShingle A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
Santos, Clementina M.M.
Diabetes
a-Glucosidase
Inhibition
QSAR
Xanthone
title_short A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
title_full A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
title_fullStr A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
title_full_unstemmed A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
title_sort A comprehensive review on xanthone derivatives as α-glucosidase inhibitors
author Santos, Clementina M.M.
author_facet Santos, Clementina M.M.
Freitas, Marisa
Fernandes, Eduarda
author_role author
author2 Freitas, Marisa
Fernandes, Eduarda
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Santos, Clementina M.M.
Freitas, Marisa
Fernandes, Eduarda
dc.subject.por.fl_str_mv Diabetes
a-Glucosidase
Inhibition
QSAR
Xanthone
topic Diabetes
a-Glucosidase
Inhibition
QSAR
Xanthone
description α-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of α-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-01-09T11:11:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/18353
url http://hdl.handle.net/10198/18353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santos, Clementina M.M.; Freitas, Marisa; Fernandes, Eduarda (2018). A comprehensive review on xanthone derivatives as α-glucosidase inhibitors. European Journal of Medicinal Chemistry. ISSN 0223-5234. 157, p. 1460-1479
0223-5234
10.1016/j.ejmech.2018.07.073
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Masson
publisher.none.fl_str_mv Elsevier Masson
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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