Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Emanuel
Data de Publicação: 2018
Outros Autores: Machado, Ausenda, Silva, Susana, Nunes, Baltazar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1111/irv.12501
Resumo: Background: The aim of this study was to estimate excess pneumonia and influenza (P&I) hospitalizations during influenza epidemics and measure their correlation with influenza vaccine coverage in the 65 and more years old, according to the type/subtype of influenza virus. Methods: The study period comprised week 40/1998-40/2015. Age-specific weekly P&I hospitalizations (ICD-9: 480-487) as main diagnosis were extracted from the National Hospital Discharge database. Age-specific baseline hospitalization rates were estimated by autoregressive integrated moving average (ARIMA) model without time periods with excess hospitalizations. Excess hospitalizations were calculated by subtracting expected hospitalization rates from the observed during influenza epidemic periods. Correlation between excess P&I hospitalizations and influenza vaccine coverage in the elderly was measured with Pearson correlation coefficient. Results: The average excess P&I hospitalizations/season was 19.4/105 (range 0-46.1/105), and higher excess was observed in young children with <2 years (79.8/105) and ≥65 years (68.3/105). In epidemics with A(H3) dominant, the highest excess hospitalizations were observed among 65 and over. Seasons which influenza B or A(H1)pdm09 dominance the highest excess was observed in children with <2 years. High negative correlation was estimated between excess hospitalizations associated with A(H3) circulation and vaccine coverage in the elderly (r = −.653; 95% CI: −0.950 to −0.137). Conclusion: Over 80% of the influenza epidemics were associated with excess hospitalizations. However, excess P&I hospitalizations pattern differed from age group and circulating virus. This ecologic approach also identified a reduction in excess P&I associated with A(H3) circulation with increasing vaccine coverage in the elderly.
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spelling Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015autoregressive integrated moving average modelsexcess hospitalizationsinfluenza epidemicsvaccine coverageEpidemiologyPulmonary and Respiratory MedicinePublic Health, Environmental and Occupational HealthInfectious DiseasesSDG 3 - Good Health and Well-beingBackground: The aim of this study was to estimate excess pneumonia and influenza (P&I) hospitalizations during influenza epidemics and measure their correlation with influenza vaccine coverage in the 65 and more years old, according to the type/subtype of influenza virus. Methods: The study period comprised week 40/1998-40/2015. Age-specific weekly P&I hospitalizations (ICD-9: 480-487) as main diagnosis were extracted from the National Hospital Discharge database. Age-specific baseline hospitalization rates were estimated by autoregressive integrated moving average (ARIMA) model without time periods with excess hospitalizations. Excess hospitalizations were calculated by subtracting expected hospitalization rates from the observed during influenza epidemic periods. Correlation between excess P&I hospitalizations and influenza vaccine coverage in the elderly was measured with Pearson correlation coefficient. Results: The average excess P&I hospitalizations/season was 19.4/105 (range 0-46.1/105), and higher excess was observed in young children with <2 years (79.8/105) and ≥65 years (68.3/105). In epidemics with A(H3) dominant, the highest excess hospitalizations were observed among 65 and over. Seasons which influenza B or A(H1)pdm09 dominance the highest excess was observed in children with <2 years. High negative correlation was estimated between excess hospitalizations associated with A(H3) circulation and vaccine coverage in the elderly (r = −.653; 95% CI: −0.950 to −0.137). Conclusion: Over 80% of the influenza epidemics were associated with excess hospitalizations. However, excess P&I hospitalizations pattern differed from age group and circulating virus. This ecologic approach also identified a reduction in excess P&I associated with A(H3) circulation with increasing vaccine coverage in the elderly.Centro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNRodrigues, EmanuelMachado, AusendaSilva, SusanaNunes, Baltazar2018-04-16T22:17:53Z2018-01-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttps://doi.org/10.1111/irv.12501eng1750-2640PURE: 3934272http://www.scopus.com/inward/record.url?scp=85042268541&partnerID=8YFLogxKhttps://doi.org/10.1111/irv.12501info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:19:01Zoai:run.unl.pt:10362/34710Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:12.352401Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
title Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
spellingShingle Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
Rodrigues, Emanuel
autoregressive integrated moving average models
excess hospitalizations
influenza epidemics
vaccine coverage
Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
title_full Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
title_fullStr Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
title_full_unstemmed Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
title_sort Excess pneumonia and influenza hospitalizations associated with influenza epidemics in Portugal from season 1998/1999 to 2014/2015
author Rodrigues, Emanuel
author_facet Rodrigues, Emanuel
Machado, Ausenda
Silva, Susana
Nunes, Baltazar
author_role author
author2 Machado, Ausenda
Silva, Susana
Nunes, Baltazar
author2_role author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Rodrigues, Emanuel
Machado, Ausenda
Silva, Susana
Nunes, Baltazar
dc.subject.por.fl_str_mv autoregressive integrated moving average models
excess hospitalizations
influenza epidemics
vaccine coverage
Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
topic autoregressive integrated moving average models
excess hospitalizations
influenza epidemics
vaccine coverage
Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
description Background: The aim of this study was to estimate excess pneumonia and influenza (P&I) hospitalizations during influenza epidemics and measure their correlation with influenza vaccine coverage in the 65 and more years old, according to the type/subtype of influenza virus. Methods: The study period comprised week 40/1998-40/2015. Age-specific weekly P&I hospitalizations (ICD-9: 480-487) as main diagnosis were extracted from the National Hospital Discharge database. Age-specific baseline hospitalization rates were estimated by autoregressive integrated moving average (ARIMA) model without time periods with excess hospitalizations. Excess hospitalizations were calculated by subtracting expected hospitalization rates from the observed during influenza epidemic periods. Correlation between excess P&I hospitalizations and influenza vaccine coverage in the elderly was measured with Pearson correlation coefficient. Results: The average excess P&I hospitalizations/season was 19.4/105 (range 0-46.1/105), and higher excess was observed in young children with <2 years (79.8/105) and ≥65 years (68.3/105). In epidemics with A(H3) dominant, the highest excess hospitalizations were observed among 65 and over. Seasons which influenza B or A(H1)pdm09 dominance the highest excess was observed in children with <2 years. High negative correlation was estimated between excess hospitalizations associated with A(H3) circulation and vaccine coverage in the elderly (r = −.653; 95% CI: −0.950 to −0.137). Conclusion: Over 80% of the influenza epidemics were associated with excess hospitalizations. However, excess P&I hospitalizations pattern differed from age group and circulating virus. This ecologic approach also identified a reduction in excess P&I associated with A(H3) circulation with increasing vaccine coverage in the elderly.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-16T22:17:53Z
2018-01-01
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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url https://doi.org/10.1111/irv.12501
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1750-2640
PURE: 3934272
http://www.scopus.com/inward/record.url?scp=85042268541&partnerID=8YFLogxK
https://doi.org/10.1111/irv.12501
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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