Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/101613 https://doi.org/10.1167/iovs.18-26325 |
Resumo: | For the past 2 decades, neuroimaging studies in dyslexia have pointed toward a hypoactivation of the ventral occipitotemporal cortex (VOTC), a region that has been closely associated to reading through the extraction of a representation of words which is invariant to position, size, font or case. However, most of the studies are confined to the visual word form area (VWFA), while recent studies have demonstrated a posterior-to-anterior gradient of print specificity along the VOTC. In our study, the whole VOTC, partitioned into three main patches of cortex, is assessed in dyslexic and control adults. A total of 30 participants were included in this study (14 developmental dyslexics and 16 age- and education-matched controls). The design consisted of alternately viewed blocks of stimuli from a given class (words, consonant strings, phase-scrambled words, phasescrambled consonant strings, small checkerboards, large checkerboards). The analyzed contrast was print stimuli (words and consonants) versus scrambled stimuli and checkerboards. RESULTS. Corroborating previous findings, our results showed underactivation to print stimuli in the VWFA of dyslexics. Additionally, differences between dyslexics and controls were also found, particularly in an area of the anterior partition of the VOTC, suggesting a relevant role of this area in word processing. CONCLUSIONS. In sum, our study goes beyond the underactivation hypothesis in the VWFA of dyslexics and indicates that a particular area on the anterior fusiform region might be particularly involved in the reading deficits in dyslexia, demonstrating the involvement of multiple areas within VOTC in reading processes. |
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Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Areadevelopmental dyslexiafMRIvisual word form area (VWFA)ventral occipitotemporal cortex (VOTC)AdultBrain MappingDyslexiaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysOccipital LobePhoneticsReaction TimeReadingTemporal LobeYoung AdultFor the past 2 decades, neuroimaging studies in dyslexia have pointed toward a hypoactivation of the ventral occipitotemporal cortex (VOTC), a region that has been closely associated to reading through the extraction of a representation of words which is invariant to position, size, font or case. However, most of the studies are confined to the visual word form area (VWFA), while recent studies have demonstrated a posterior-to-anterior gradient of print specificity along the VOTC. In our study, the whole VOTC, partitioned into three main patches of cortex, is assessed in dyslexic and control adults. A total of 30 participants were included in this study (14 developmental dyslexics and 16 age- and education-matched controls). The design consisted of alternately viewed blocks of stimuli from a given class (words, consonant strings, phase-scrambled words, phasescrambled consonant strings, small checkerboards, large checkerboards). The analyzed contrast was print stimuli (words and consonants) versus scrambled stimuli and checkerboards. RESULTS. Corroborating previous findings, our results showed underactivation to print stimuli in the VWFA of dyslexics. Additionally, differences between dyslexics and controls were also found, particularly in an area of the anterior partition of the VOTC, suggesting a relevant role of this area in word processing. CONCLUSIONS. In sum, our study goes beyond the underactivation hypothesis in the VWFA of dyslexics and indicates that a particular area on the anterior fusiform region might be particularly involved in the reading deficits in dyslexia, demonstrating the involvement of multiple areas within VOTC in reading processes.2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/101613http://hdl.handle.net/10316/101613https://doi.org/10.1167/iovs.18-26325eng1552-5783Rodrigues, Ana PinaRebola, JoséPereira, Marcelinovan Asselen, MariekeCastelo Branco, Miguel de Sá e Sousainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-02T20:48:28Zoai:estudogeral.uc.pt:10316/101613Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:18:46.173415Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
title |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
spellingShingle |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area Rodrigues, Ana Pina developmental dyslexia fMRI visual word form area (VWFA) ventral occipitotemporal cortex (VOTC) Adult Brain Mapping Dyslexia Female Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways Occipital Lobe Phonetics Reaction Time Reading Temporal Lobe Young Adult |
title_short |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
title_full |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
title_fullStr |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
title_full_unstemmed |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
title_sort |
Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area |
author |
Rodrigues, Ana Pina |
author_facet |
Rodrigues, Ana Pina Rebola, José Pereira, Marcelino van Asselen, Marieke Castelo Branco, Miguel de Sá e Sousa |
author_role |
author |
author2 |
Rebola, José Pereira, Marcelino van Asselen, Marieke Castelo Branco, Miguel de Sá e Sousa |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Ana Pina Rebola, José Pereira, Marcelino van Asselen, Marieke Castelo Branco, Miguel de Sá e Sousa |
dc.subject.por.fl_str_mv |
developmental dyslexia fMRI visual word form area (VWFA) ventral occipitotemporal cortex (VOTC) Adult Brain Mapping Dyslexia Female Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways Occipital Lobe Phonetics Reaction Time Reading Temporal Lobe Young Adult |
topic |
developmental dyslexia fMRI visual word form area (VWFA) ventral occipitotemporal cortex (VOTC) Adult Brain Mapping Dyslexia Female Humans Magnetic Resonance Imaging Male Middle Aged Neural Pathways Occipital Lobe Phonetics Reaction Time Reading Temporal Lobe Young Adult |
description |
For the past 2 decades, neuroimaging studies in dyslexia have pointed toward a hypoactivation of the ventral occipitotemporal cortex (VOTC), a region that has been closely associated to reading through the extraction of a representation of words which is invariant to position, size, font or case. However, most of the studies are confined to the visual word form area (VWFA), while recent studies have demonstrated a posterior-to-anterior gradient of print specificity along the VOTC. In our study, the whole VOTC, partitioned into three main patches of cortex, is assessed in dyslexic and control adults. A total of 30 participants were included in this study (14 developmental dyslexics and 16 age- and education-matched controls). The design consisted of alternately viewed blocks of stimuli from a given class (words, consonant strings, phase-scrambled words, phasescrambled consonant strings, small checkerboards, large checkerboards). The analyzed contrast was print stimuli (words and consonants) versus scrambled stimuli and checkerboards. RESULTS. Corroborating previous findings, our results showed underactivation to print stimuli in the VWFA of dyslexics. Additionally, differences between dyslexics and controls were also found, particularly in an area of the anterior partition of the VOTC, suggesting a relevant role of this area in word processing. CONCLUSIONS. In sum, our study goes beyond the underactivation hypothesis in the VWFA of dyslexics and indicates that a particular area on the anterior fusiform region might be particularly involved in the reading deficits in dyslexia, demonstrating the involvement of multiple areas within VOTC in reading processes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/101613 http://hdl.handle.net/10316/101613 https://doi.org/10.1167/iovs.18-26325 |
url |
http://hdl.handle.net/10316/101613 https://doi.org/10.1167/iovs.18-26325 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1552-5783 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134082265776128 |