How do Kinetochores CLASP Dynamic Microtubules?

Detalhes bibliográficos
Autor(a) principal: Maiato, H
Data de Publicação: 2003
Outros Autores: Rieder, CL, Earnshaw, WC, Sunkel, CE
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/35062
Resumo: Maintenance of genetic stability during cell division requires binding of chromosomes to the mitotic spindle, a process that involves attachment of spindle microtubules to kinetochores. This enables chromosomes to move to the metaphase plate, to satisfy the spindle checkpoint and finally to segregate during anaphase. Recent studies on the function MAST in Drosophila and its human homologue CLASP1, have revealed that these microtubule-associated proteins play an essential role for the kinetochore-microtubule interaction. CLASP1 localizes to the plus ends of growing microtubules and to the most external kinetochore domain. Depletion of CLASP1 causes abnormal chromosome congression, collapse of the mitotic spindle and attachment of kinetochores to very short microtubules that do not show dynamic behavior. These results suggest that CLASP1 is required at kinetochores to regulate the dynamic behavior of attached microtubules.
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spelling How do Kinetochores CLASP Dynamic Microtubules?MicrotubulesMAPsMastOrbitCLASPTIPsDynamicsKinetochoresSpindleMitosisMaintenance of genetic stability during cell division requires binding of chromosomes to the mitotic spindle, a process that involves attachment of spindle microtubules to kinetochores. This enables chromosomes to move to the metaphase plate, to satisfy the spindle checkpoint and finally to segregate during anaphase. Recent studies on the function MAST in Drosophila and its human homologue CLASP1, have revealed that these microtubule-associated proteins play an essential role for the kinetochore-microtubule interaction. CLASP1 localizes to the plus ends of growing microtubules and to the most external kinetochore domain. Depletion of CLASP1 causes abnormal chromosome congression, collapse of the mitotic spindle and attachment of kinetochores to very short microtubules that do not show dynamic behavior. These results suggest that CLASP1 is required at kinetochores to regulate the dynamic behavior of attached microtubules.20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/35062eng1538-4101Maiato, HRieder, CLEarnshaw, WCSunkel, CEinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-27T09:11:15Zoai:repositorio-aberto.up.pt:10216/35062Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-27T09:11:15Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How do Kinetochores CLASP Dynamic Microtubules?
title How do Kinetochores CLASP Dynamic Microtubules?
spellingShingle How do Kinetochores CLASP Dynamic Microtubules?
Maiato, H
Microtubules
MAPs
Mast
Orbit
CLASP
TIPs
Dynamics
Kinetochores
Spindle
Mitosis
title_short How do Kinetochores CLASP Dynamic Microtubules?
title_full How do Kinetochores CLASP Dynamic Microtubules?
title_fullStr How do Kinetochores CLASP Dynamic Microtubules?
title_full_unstemmed How do Kinetochores CLASP Dynamic Microtubules?
title_sort How do Kinetochores CLASP Dynamic Microtubules?
author Maiato, H
author_facet Maiato, H
Rieder, CL
Earnshaw, WC
Sunkel, CE
author_role author
author2 Rieder, CL
Earnshaw, WC
Sunkel, CE
author2_role author
author
author
dc.contributor.author.fl_str_mv Maiato, H
Rieder, CL
Earnshaw, WC
Sunkel, CE
dc.subject.por.fl_str_mv Microtubules
MAPs
Mast
Orbit
CLASP
TIPs
Dynamics
Kinetochores
Spindle
Mitosis
topic Microtubules
MAPs
Mast
Orbit
CLASP
TIPs
Dynamics
Kinetochores
Spindle
Mitosis
description Maintenance of genetic stability during cell division requires binding of chromosomes to the mitotic spindle, a process that involves attachment of spindle microtubules to kinetochores. This enables chromosomes to move to the metaphase plate, to satisfy the spindle checkpoint and finally to segregate during anaphase. Recent studies on the function MAST in Drosophila and its human homologue CLASP1, have revealed that these microtubule-associated proteins play an essential role for the kinetochore-microtubule interaction. CLASP1 localizes to the plus ends of growing microtubules and to the most external kinetochore domain. Depletion of CLASP1 causes abnormal chromosome congression, collapse of the mitotic spindle and attachment of kinetochores to very short microtubules that do not show dynamic behavior. These results suggest that CLASP1 is required at kinetochores to regulate the dynamic behavior of attached microtubules.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/35062
url http://hdl.handle.net/10216/35062
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1538-4101
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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