Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts

Detalhes bibliográficos
Autor(a) principal: Gomes, AL
Data de Publicação: 2001
Outros Autores: Vieira, JP, Saldanha, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2341
Resumo: We report two cases of a peculiar leukoencephalopathy with temporal cysts. Both patients have a non-progressive neurological disorder with mental retardation, microcephaly and sensorineural deafness although clinical differences between them may reflect a different aetiology. The metabolic disorders with white matter involvement and the recently described leukoencephalopathies (Van Der Knaap disease, 'vanishing white matter disease') were excluded based on clinical, biologic and imaging findings. Cytomegalovirus infection is a likely possibility in the first case although the magnetic resonance imaging picture is only partially similar to previously reported cases. Our patients are strikingly similar to the patients reported by Deonna et al. and Olivier et al. We discuss the clinical and imaging findings in our patients and the differential diagnosis considering the known disorders of the white matter in childhood.
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spelling Non-Progressive Leukoencephalopathy with Bilateral Temporal CystsCentral Nervous System Cysts/diagnosisCerebral Cortex/pathologyCytomegalovirus Infections/congenitalCytomegalovirus Infections/diagnosisDemyelinating Diseases/diagnosisDiagnosis, DifferentialDominance, Cerebral/physiologyIntellectual Disability/diagnosisMagnetic Resonance ImagingChildInfant, Low Birth WeightFollow-Up StudiesHDE NEU PEDWe report two cases of a peculiar leukoencephalopathy with temporal cysts. Both patients have a non-progressive neurological disorder with mental retardation, microcephaly and sensorineural deafness although clinical differences between them may reflect a different aetiology. The metabolic disorders with white matter involvement and the recently described leukoencephalopathies (Van Der Knaap disease, 'vanishing white matter disease') were excluded based on clinical, biologic and imaging findings. Cytomegalovirus infection is a likely possibility in the first case although the magnetic resonance imaging picture is only partially similar to previously reported cases. Our patients are strikingly similar to the patients reported by Deonna et al. and Olivier et al. We discuss the clinical and imaging findings in our patients and the differential diagnosis considering the known disorders of the white matter in childhood.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEGomes, ALVieira, JPSaldanha, J2015-11-11T13:02:27Z20012001-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2341engEur J Paediatr Neurol. 2001;5(3):121-5.10.1053/ejpn.2001.0482info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:36:30Zoai:repositorio.chlc.min-saude.pt:10400.17/2341Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:42.169453Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
title Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
spellingShingle Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
Gomes, AL
Central Nervous System Cysts/diagnosis
Cerebral Cortex/pathology
Cytomegalovirus Infections/congenital
Cytomegalovirus Infections/diagnosis
Demyelinating Diseases/diagnosis
Diagnosis, Differential
Dominance, Cerebral/physiology
Intellectual Disability/diagnosis
Magnetic Resonance Imaging
Child
Infant, Low Birth Weight
Follow-Up Studies
HDE NEU PED
title_short Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
title_full Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
title_fullStr Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
title_full_unstemmed Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
title_sort Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts
author Gomes, AL
author_facet Gomes, AL
Vieira, JP
Saldanha, J
author_role author
author2 Vieira, JP
Saldanha, J
author2_role author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Gomes, AL
Vieira, JP
Saldanha, J
dc.subject.por.fl_str_mv Central Nervous System Cysts/diagnosis
Cerebral Cortex/pathology
Cytomegalovirus Infections/congenital
Cytomegalovirus Infections/diagnosis
Demyelinating Diseases/diagnosis
Diagnosis, Differential
Dominance, Cerebral/physiology
Intellectual Disability/diagnosis
Magnetic Resonance Imaging
Child
Infant, Low Birth Weight
Follow-Up Studies
HDE NEU PED
topic Central Nervous System Cysts/diagnosis
Cerebral Cortex/pathology
Cytomegalovirus Infections/congenital
Cytomegalovirus Infections/diagnosis
Demyelinating Diseases/diagnosis
Diagnosis, Differential
Dominance, Cerebral/physiology
Intellectual Disability/diagnosis
Magnetic Resonance Imaging
Child
Infant, Low Birth Weight
Follow-Up Studies
HDE NEU PED
description We report two cases of a peculiar leukoencephalopathy with temporal cysts. Both patients have a non-progressive neurological disorder with mental retardation, microcephaly and sensorineural deafness although clinical differences between them may reflect a different aetiology. The metabolic disorders with white matter involvement and the recently described leukoencephalopathies (Van Der Knaap disease, 'vanishing white matter disease') were excluded based on clinical, biologic and imaging findings. Cytomegalovirus infection is a likely possibility in the first case although the magnetic resonance imaging picture is only partially similar to previously reported cases. Our patients are strikingly similar to the patients reported by Deonna et al. and Olivier et al. We discuss the clinical and imaging findings in our patients and the differential diagnosis considering the known disorders of the white matter in childhood.
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01T00:00:00Z
2015-11-11T13:02:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2341
url http://hdl.handle.net/10400.17/2341
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Paediatr Neurol. 2001;5(3):121-5.
10.1053/ejpn.2001.0482
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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