Mitochondrial biogenesis in neurons: how and where

Detalhes bibliográficos
Autor(a) principal: Cardanho-Ramos, Carlos
Data de Publicação: 2021
Outros Autores: Morais, Vanessa A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50471
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Mitochondrial biogenesis in neurons: how and whereNRF-1/2PGC-1αTFAMCell bodyMitochondrial biogenesisNeurodegenerative diseasesNeuronsPeriphery© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Neurons rely mostly on mitochondria for the production of ATP and Ca2+ homeostasis. As sub-compartmentalized cells, they have different pools of mitochondria in each compartment that are maintained by a constant mitochondrial turnover. It is assumed that most mitochondria are generated in the cell body and then travel to the synapse to exert their functions. Once damaged, mitochondria have to travel back to the cell body for degradation. However, in long cells, like motor neurons, this constant travel back and forth is not an energetically favourable process, thus mitochondrial biogenesis must also occur at the periphery. Ca2+ and ATP levels are the main triggers for mitochondrial biogenesis in the cell body, in a mechanism dependent on the Peroxisome-proliferator-activated γ co-activator-1α-nuclear respiration factors 1 and 2-mitochondrial transcription factor A (PGC-1α-NRF-1/2-TFAM) pathway. However, even though of extreme importance, very little is known about the mechanisms promoting mitochondrial biogenesis away from the cell body. In this review, we bring forward the evoked mechanisms that are at play for mitochondrial biogenesis in the cell body and periphery. Moreover, we postulate that mitochondrial biogenesis may vary locally within the same neuron, and we build upon the hypotheses that, in the periphery, local protein synthesis is responsible for giving all the machinery required for mitochondria to replicate themselves.This research was funded by FCT—Fundação para a Ciência e Tecnologia, Grant Numbers: IF/01693/2014, PD/BD/135521/2018; UID/BIM/50005/2019; H2020 European Research Council, Grant Number: ERCStG-679168; European Molecular Biology Organization, Grant Number: EMBOIG/3309.MDPIRepositório da Universidade de LisboaCardanho-Ramos, CarlosMorais, Vanessa A.2021-12-20T16:51:08Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50471engInt J Mol Sci. 2021 Dec 2;22(23):13059.1422-006710.3390/ijms2223130591422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:41Zoai:repositorio.ul.pt:10451/50471Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:55.655448Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mitochondrial biogenesis in neurons: how and where
title Mitochondrial biogenesis in neurons: how and where
spellingShingle Mitochondrial biogenesis in neurons: how and where
Cardanho-Ramos, Carlos
NRF-1/2
PGC-1α
TFAM
Cell body
Mitochondrial biogenesis
Neurodegenerative diseases
Neurons
Periphery
title_short Mitochondrial biogenesis in neurons: how and where
title_full Mitochondrial biogenesis in neurons: how and where
title_fullStr Mitochondrial biogenesis in neurons: how and where
title_full_unstemmed Mitochondrial biogenesis in neurons: how and where
title_sort Mitochondrial biogenesis in neurons: how and where
author Cardanho-Ramos, Carlos
author_facet Cardanho-Ramos, Carlos
Morais, Vanessa A.
author_role author
author2 Morais, Vanessa A.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Cardanho-Ramos, Carlos
Morais, Vanessa A.
dc.subject.por.fl_str_mv NRF-1/2
PGC-1α
TFAM
Cell body
Mitochondrial biogenesis
Neurodegenerative diseases
Neurons
Periphery
topic NRF-1/2
PGC-1α
TFAM
Cell body
Mitochondrial biogenesis
Neurodegenerative diseases
Neurons
Periphery
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-12-20T16:51:08Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50471
url http://hdl.handle.net/10451/50471
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Mol Sci. 2021 Dec 2;22(23):13059.
1422-0067
10.3390/ijms222313059
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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publisher.none.fl_str_mv MDPI
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