Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/37201 |
Resumo: | Introduction: Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. Material and methods: An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. Results: The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. Conclusion: A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers. |
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Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic reviewBiomarkersChronic kidney diseasePeriodontitisProteinsSystematic reviewIntroduction: Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. Material and methods: An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. Results: The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. Conclusion: A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers.Veritati - Repositório Institucional da Universidade Católica PortuguesaTavares, Lisandra Taísa ReginaldoSaavedra-Silva, MarianaLópez-Marcos, Joaquín FranciscoVeiga, Nélio JorgeCastilho, Rogerio de MoraesFernandes, Gustavo Vicentis de Oliveira2022-03-30T16:09:18Z2022-02-172022-02-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/37201eng2079-972110.3390/diseases10010012PMC888393935225864000775432100001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:42:38Zoai:repositorio.ucp.pt:10400.14/37201Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:30:15.169301Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
title |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
spellingShingle |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review Tavares, Lisandra Taísa Reginaldo Biomarkers Chronic kidney disease Periodontitis Proteins Systematic review |
title_short |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
title_full |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
title_fullStr |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
title_full_unstemmed |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
title_sort |
Blood and salivary inflammatory biomarkers profile in patients with chronic kidney disease and periodontal disease: a systematic review |
author |
Tavares, Lisandra Taísa Reginaldo |
author_facet |
Tavares, Lisandra Taísa Reginaldo Saavedra-Silva, Mariana López-Marcos, Joaquín Francisco Veiga, Nélio Jorge Castilho, Rogerio de Moraes Fernandes, Gustavo Vicentis de Oliveira |
author_role |
author |
author2 |
Saavedra-Silva, Mariana López-Marcos, Joaquín Francisco Veiga, Nélio Jorge Castilho, Rogerio de Moraes Fernandes, Gustavo Vicentis de Oliveira |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Tavares, Lisandra Taísa Reginaldo Saavedra-Silva, Mariana López-Marcos, Joaquín Francisco Veiga, Nélio Jorge Castilho, Rogerio de Moraes Fernandes, Gustavo Vicentis de Oliveira |
dc.subject.por.fl_str_mv |
Biomarkers Chronic kidney disease Periodontitis Proteins Systematic review |
topic |
Biomarkers Chronic kidney disease Periodontitis Proteins Systematic review |
description |
Introduction: Periodontitis is the most prevalent inflammatory disease worldwide. Its inflammatory levels spread systemically, which can be associated with chronic kidney disease. Biomarkers have the potential to diagnose and correlate periodontitis and chronic kidney disease, helping to monitor systemic inflammation. Thereby, this study aimed to analyze the association between chronic kidney disease and periodontitis by conducting a biomarker analysis on blood and saliva. Material and methods: An electronic search through PubMed/MEDLINE, EMBASE, and Web of Science databases was conducted to identify clinical studies published in the last ten years, with no language restrictions. Twelve articles met all the inclusion criteria, two randomized controlled trials, one cohort study, and nine observational studies. Results: The studies included a total of 117 patients for saliva biomarkers, with a mean age of approximately 57 years old, and 56.68% of the subjects were female. After analyzing all the included studies, it was possible to verify the following biomarkers assessed: CRP, WBC, fibrinogen, IL-4 and -6, cardiac troponin T, NOx, ADMA, albumin, osteocalcin, cystatin C, PGLYRP1, cholesterol, HDL, LDL, triglycerides, and hemoglobin. Conclusion: A direct cause–effect association between periodontitis and CKD could not be established. However, it was possible to conclude that there was a correlating effect present, through the analyzed biomarkers. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-30T16:09:18Z 2022-02-17 2022-02-17T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/37201 |
url |
http://hdl.handle.net/10400.14/37201 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2079-9721 10.3390/diseases10010012 PMC8883939 35225864 000775432100001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132023879630848 |