Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review

• Autor(a) principal: Tavares, Lisandra Taísa Reginaldo
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.14/31085
• topic: Periodontitis; Periimplantitis; Chronic kidney disease; Salivary biomarkers; Systematic review; Periodontite; Peri-implantite; Doença renal crónica; Biomarcadores salivares; Revisão sistemática; Domínio/Área Científica::Ciências Médicas::Ciências da Saúde

Background: Periodontitis is the most prevalent inflammatory disease worldwide. Different authors have proposed that periodontal inflammation spreads systemically being associated with cardiovascular disease, the most frequent death cause in chronic kidney disease patients. Salivary biomarkers have a big potential in the diagnosis and correlation of both diseases, it can also be important in monitoring the systemic inflammation. Aim: Therefore, the aim of this study is to analyse the association between chronic kidney disease and periodontitis / periimplantitis by analysing salivary biomarkers. Materials and methods: A systematic electronic search through PubMed (MEDLINE), EMBASE and Web of Science databases was conducted by three independent reviewers to identify clinical studies performed in humans and published between January 2009 and January 2020, with no geographical or language restrictions. This systematic review followed the PRISMA guidelines. The present systematic review was registered in the PROSPERO. Results: Search strategy identified 7051 protentional eligible articles but only one met all the inclusion and exclusion criteria. The included article studied 4 salivary biomarkers, sTrem-1, PYGLRP1, IL-1β and MMP-8 in patients at predialysis stage with a follow-up of 157 months. Study results, by a confounders analysis, showed that periodontitis had a significant influence increasing the values of these inflammatory biomarkers. Conclusion: A direct cause-effect association between periodontitis and CKD cannot be established, but this work concludes that there was an effect correlating them through the analysed proinflammatory biomarkers. More controlled studies are suggested to reinforce this weak conclusion.