Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review

Detalhes bibliográficos
Autor(a) principal: Teixeira, Alexandra
Data de Publicação: 2023
Outros Autores: Carreira, Luís, Abalde-Cela, Sara, Sampaio-Marques, Belém, Areias, Anabela C., Ludovico, Paula, Diéguez, Lorena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/86586
Resumo: Acute myeloid leukemia (AML) comprises a group of hematologic neoplasms characterized by abnormal differentiation and proliferation of myeloid progenitor cells. AML is associated with poor outcome due to the lack of efficient therapies and early diagnostic tools. The current gold standard diagnostic tools are based on bone marrow biopsy. These biopsies, apart from being very invasive, painful, and costly, have low sensitivity. Despite the progress uncovering the molecular pathogenesis of AML, the development of novel detection strategies is still poorly explored. This is particularly important for patients that check the criteria for complete remission after treatment, since they can relapse through the persistence of some leukemic stem cells. This condition, recently named as measurable residual disease (MRD), has severe consequences for disease progression. Hence, an early and accurate diagnosis of MRD would allow an appropriate therapy to be tailored, improving a patient’s prognosis. Many novel techniques with high potential in disease prevention and early detection are being explored. Among them, microfluidics has flourished in recent years due to its ability at processing complex samples as well as its demonstrated capacity to isolate rare cells from biological fluids. In parallel, surface-enhanced Raman scattering (SERS) spectroscopy has shown outstanding sensitivity and capability for multiplex quantitative detection of disease biomarkers. Together, these technologies can allow early and cost-effective disease detection as well as contribute to monitoring the efficiency of treatments. In this review, we aim to provide a comprehensive overview of AML disease, the conventional techniques currently used for its diagnosis, classification (recently updated in September 2022), and treatment selection, and we also aim to present how novel technologies can be applied to improve the detection and monitoring of MRD.
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spelling Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative reviewAcute myeloid leukemia (AML)Measurable residual disease (MRD)MicrofluidicsSurface-enhanced Raman scattering (SERS)Science & TechnologyAcute myeloid leukemia (AML) comprises a group of hematologic neoplasms characterized by abnormal differentiation and proliferation of myeloid progenitor cells. AML is associated with poor outcome due to the lack of efficient therapies and early diagnostic tools. The current gold standard diagnostic tools are based on bone marrow biopsy. These biopsies, apart from being very invasive, painful, and costly, have low sensitivity. Despite the progress uncovering the molecular pathogenesis of AML, the development of novel detection strategies is still poorly explored. This is particularly important for patients that check the criteria for complete remission after treatment, since they can relapse through the persistence of some leukemic stem cells. This condition, recently named as measurable residual disease (MRD), has severe consequences for disease progression. Hence, an early and accurate diagnosis of MRD would allow an appropriate therapy to be tailored, improving a patient’s prognosis. Many novel techniques with high potential in disease prevention and early detection are being explored. Among them, microfluidics has flourished in recent years due to its ability at processing complex samples as well as its demonstrated capacity to isolate rare cells from biological fluids. In parallel, surface-enhanced Raman scattering (SERS) spectroscopy has shown outstanding sensitivity and capability for multiplex quantitative detection of disease biomarkers. Together, these technologies can allow early and cost-effective disease detection as well as contribute to monitoring the efficiency of treatments. In this review, we aim to provide a comprehensive overview of AML disease, the conventional techniques currently used for its diagnosis, classification (recently updated in September 2022), and treatment selection, and we also aim to present how novel technologies can be applied to improve the detection and monitoring of MRD.This work was supported by European Regional Development Fund (ERDF) through COMPETE2020, under the IMPAct-L project (030782); by the Foundation for Science and Technology (FCT) projects UIDB/50026/2020 and UIDP/50026/2020; and by the project NORTE-01-0145-FEDER-000055, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This project also received funding of the project Health From Portugal (C630926586-00465198), supported by Component C5–Capitalisation and Business Innovation, under the Portuguese Resilience and Recovery Plan, through the NextGenerationEU Fund. A.T. acknowledges the FCT studentship SFRH/BD/148091/2019. B.S.-M. acknowledges funding by FCT, grant number DL 57/2016.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoTeixeira, AlexandraCarreira, LuísAbalde-Cela, SaraSampaio-Marques, BelémAreias, Anabela C.Ludovico, PaulaDiéguez, Lorena2023-02-212023-02-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/86586engTeixeira, A.; Carreira, L.; Abalde-Cela, S.; Sampaio-Marques, B.; Areias, A.C.; Ludovico, P.; Diéguez, L. Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review. Cancers 2023, 15, 1362. https://doi.org/10.3390/cancers150513622072-669410.3390/cancers150513621362https://www.mdpi.com/2072-6694/15/5/1362info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:38:31Zoai:repositorium.sdum.uminho.pt:1822/86586Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:31:45.263420Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
title Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
spellingShingle Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
Teixeira, Alexandra
Acute myeloid leukemia (AML)
Measurable residual disease (MRD)
Microfluidics
Surface-enhanced Raman scattering (SERS)
Science & Technology
title_short Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
title_full Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
title_fullStr Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
title_full_unstemmed Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
title_sort Current and emerging techniques for diagnosis and MRD detection in AML: a comprehensive narrative review
author Teixeira, Alexandra
author_facet Teixeira, Alexandra
Carreira, Luís
Abalde-Cela, Sara
Sampaio-Marques, Belém
Areias, Anabela C.
Ludovico, Paula
Diéguez, Lorena
author_role author
author2 Carreira, Luís
Abalde-Cela, Sara
Sampaio-Marques, Belém
Areias, Anabela C.
Ludovico, Paula
Diéguez, Lorena
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Teixeira, Alexandra
Carreira, Luís
Abalde-Cela, Sara
Sampaio-Marques, Belém
Areias, Anabela C.
Ludovico, Paula
Diéguez, Lorena
dc.subject.por.fl_str_mv Acute myeloid leukemia (AML)
Measurable residual disease (MRD)
Microfluidics
Surface-enhanced Raman scattering (SERS)
Science & Technology
topic Acute myeloid leukemia (AML)
Measurable residual disease (MRD)
Microfluidics
Surface-enhanced Raman scattering (SERS)
Science & Technology
description Acute myeloid leukemia (AML) comprises a group of hematologic neoplasms characterized by abnormal differentiation and proliferation of myeloid progenitor cells. AML is associated with poor outcome due to the lack of efficient therapies and early diagnostic tools. The current gold standard diagnostic tools are based on bone marrow biopsy. These biopsies, apart from being very invasive, painful, and costly, have low sensitivity. Despite the progress uncovering the molecular pathogenesis of AML, the development of novel detection strategies is still poorly explored. This is particularly important for patients that check the criteria for complete remission after treatment, since they can relapse through the persistence of some leukemic stem cells. This condition, recently named as measurable residual disease (MRD), has severe consequences for disease progression. Hence, an early and accurate diagnosis of MRD would allow an appropriate therapy to be tailored, improving a patient’s prognosis. Many novel techniques with high potential in disease prevention and early detection are being explored. Among them, microfluidics has flourished in recent years due to its ability at processing complex samples as well as its demonstrated capacity to isolate rare cells from biological fluids. In parallel, surface-enhanced Raman scattering (SERS) spectroscopy has shown outstanding sensitivity and capability for multiplex quantitative detection of disease biomarkers. Together, these technologies can allow early and cost-effective disease detection as well as contribute to monitoring the efficiency of treatments. In this review, we aim to provide a comprehensive overview of AML disease, the conventional techniques currently used for its diagnosis, classification (recently updated in September 2022), and treatment selection, and we also aim to present how novel technologies can be applied to improve the detection and monitoring of MRD.
publishDate 2023
dc.date.none.fl_str_mv 2023-02-21
2023-02-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/86586
url https://hdl.handle.net/1822/86586
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Teixeira, A.; Carreira, L.; Abalde-Cela, S.; Sampaio-Marques, B.; Areias, A.C.; Ludovico, P.; Diéguez, L. Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review. Cancers 2023, 15, 1362. https://doi.org/10.3390/cancers15051362
2072-6694
10.3390/cancers15051362
1362
https://www.mdpi.com/2072-6694/15/5/1362
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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