A whole genome screen for association with multiple sclerosis in portuguese patients

Detalhes bibliográficos
Autor(a) principal: Santos, M.
Data de Publicação: 2003
Outros Autores: Pinto-Basto, J., Rio, M. E., Valença, Angela, Sá, Alfredo, Dinis, J., Figueiredo, J., Bigotte de Almeida, Luís, Coelho, I., Sawcer, S., Setakis, E., Compston, A., Sequeiros, Jorge, Maciel, P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/1646
Resumo: Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n = 188) and matched controls (n = 188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
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spelling A whole genome screen for association with multiple sclerosis in portuguese patientsGenome screenLinkage disequilibriumPortugalMultiple sclerosisDNA poolingScience & TechnologyMultiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n = 188) and matched controls (n = 188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.SERONO (Portugal).Fundação para a Ciência e a Tecnologia (FCT) - grant FRH/BD/9111/2002.British Council/ICCTI.Wellcome Trust, Multiple Sclerosis Societies of the United States and Great Britain, Multiple Sclerosis International Federation - GAMES project - grant 057097.ElsevierUniversidade do MinhoSantos, M.Pinto-Basto, J.Rio, M. E.Valença, AngelaSá, AlfredoDinis, J.Figueiredo, J.Bigotte de Almeida, LuísCoelho, I.Sawcer, S.Setakis, E.Compston, A.Sequeiros, JorgeMaciel, P.20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/1646eng"Journal of neuroimmunology". ISSN 0165-5728. 143 (2003) 112–115.0165-572810.1016/j.jneuroim.2003.08.02314575926http://www.elsevier.com/wps/find/homepage.cws_homeinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:11:24Zoai:repositorium.sdum.uminho.pt:1822/1646Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:03:11.330402Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A whole genome screen for association with multiple sclerosis in portuguese patients
title A whole genome screen for association with multiple sclerosis in portuguese patients
spellingShingle A whole genome screen for association with multiple sclerosis in portuguese patients
Santos, M.
Genome screen
Linkage disequilibrium
Portugal
Multiple sclerosis
DNA pooling
Science & Technology
title_short A whole genome screen for association with multiple sclerosis in portuguese patients
title_full A whole genome screen for association with multiple sclerosis in portuguese patients
title_fullStr A whole genome screen for association with multiple sclerosis in portuguese patients
title_full_unstemmed A whole genome screen for association with multiple sclerosis in portuguese patients
title_sort A whole genome screen for association with multiple sclerosis in portuguese patients
author Santos, M.
author_facet Santos, M.
Pinto-Basto, J.
Rio, M. E.
Valença, Angela
Sá, Alfredo
Dinis, J.
Figueiredo, J.
Bigotte de Almeida, Luís
Coelho, I.
Sawcer, S.
Setakis, E.
Compston, A.
Sequeiros, Jorge
Maciel, P.
author_role author
author2 Pinto-Basto, J.
Rio, M. E.
Valença, Angela
Sá, Alfredo
Dinis, J.
Figueiredo, J.
Bigotte de Almeida, Luís
Coelho, I.
Sawcer, S.
Setakis, E.
Compston, A.
Sequeiros, Jorge
Maciel, P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, M.
Pinto-Basto, J.
Rio, M. E.
Valença, Angela
Sá, Alfredo
Dinis, J.
Figueiredo, J.
Bigotte de Almeida, Luís
Coelho, I.
Sawcer, S.
Setakis, E.
Compston, A.
Sequeiros, Jorge
Maciel, P.
dc.subject.por.fl_str_mv Genome screen
Linkage disequilibrium
Portugal
Multiple sclerosis
DNA pooling
Science & Technology
topic Genome screen
Linkage disequilibrium
Portugal
Multiple sclerosis
DNA pooling
Science & Technology
description Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n = 188) and matched controls (n = 188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/1646
url http://hdl.handle.net/1822/1646
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Journal of neuroimmunology". ISSN 0165-5728. 143 (2003) 112–115.
0165-5728
10.1016/j.jneuroim.2003.08.023
14575926
http://www.elsevier.com/wps/find/homepage.cws_home
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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