A whole genome screen for association with multiple sclerosis in Portuguese patients

Detalhes bibliográficos
Autor(a) principal: Santos, M
Data de Publicação: 2003
Outros Autores: Pinto-Basto, J, Rio, ME, Sá, MJ, Valença, A, Sá, A, Dinis, J, Figueiredo, J, Bigotte de Almeida, L, Coelho, I, Sawcer, S, Setakis, E, Compston, A, Sequeiros, J, Maciel, P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/463
Resumo: Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
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spelling A whole genome screen for association with multiple sclerosis in Portuguese patientsPredisposição Genética para DoençaTestes GenéticosEsclerose MúltiplaMultiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.ElsevierRepositório Científico do Hospital de BragaSantos, MPinto-Basto, JRio, MESá, MJValença, ASá, ADinis, JFigueiredo, JBigotte de Almeida, LCoelho, ISawcer, SSetakis, ECompston, ASequeiros, JMaciel, P2013-07-18T11:56:37Z2003-01-01T00:00:00Z2003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/463engJ Neuroimmunol. 2003;143(1-2):112-5.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:06Zoai:repositorio.hospitaldebraga.pt:10400.23/463Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:00.068460Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A whole genome screen for association with multiple sclerosis in Portuguese patients
title A whole genome screen for association with multiple sclerosis in Portuguese patients
spellingShingle A whole genome screen for association with multiple sclerosis in Portuguese patients
Santos, M
Predisposição Genética para Doença
Testes Genéticos
Esclerose Múltipla
title_short A whole genome screen for association with multiple sclerosis in Portuguese patients
title_full A whole genome screen for association with multiple sclerosis in Portuguese patients
title_fullStr A whole genome screen for association with multiple sclerosis in Portuguese patients
title_full_unstemmed A whole genome screen for association with multiple sclerosis in Portuguese patients
title_sort A whole genome screen for association with multiple sclerosis in Portuguese patients
author Santos, M
author_facet Santos, M
Pinto-Basto, J
Rio, ME
Sá, MJ
Valença, A
Sá, A
Dinis, J
Figueiredo, J
Bigotte de Almeida, L
Coelho, I
Sawcer, S
Setakis, E
Compston, A
Sequeiros, J
Maciel, P
author_role author
author2 Pinto-Basto, J
Rio, ME
Sá, MJ
Valença, A
Sá, A
Dinis, J
Figueiredo, J
Bigotte de Almeida, L
Coelho, I
Sawcer, S
Setakis, E
Compston, A
Sequeiros, J
Maciel, P
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Santos, M
Pinto-Basto, J
Rio, ME
Sá, MJ
Valença, A
Sá, A
Dinis, J
Figueiredo, J
Bigotte de Almeida, L
Coelho, I
Sawcer, S
Setakis, E
Compston, A
Sequeiros, J
Maciel, P
dc.subject.por.fl_str_mv Predisposição Genética para Doença
Testes Genéticos
Esclerose Múltipla
topic Predisposição Genética para Doença
Testes Genéticos
Esclerose Múltipla
description Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01T00:00:00Z
2003-01-01T00:00:00Z
2013-07-18T11:56:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/463
url http://hdl.handle.net/10400.23/463
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Neuroimmunol. 2003;143(1-2):112-5.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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