Comparative Study of Different Plasticized Membrane Electrodes for the Stability-indicative Determination of Torsemide

• Autor(a) principal: Zaazaa,H.E.
• Data de Publicação: 2012
• Outros Autores: Abbas,S.S., Essam,Hebat A.M., El-Bardicy,M. G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000500004
• topic: Torsemide-selective electrode; graphite electrode; 2-hydroxy propyl-βcyclodextrin; stability indicating study; pharmaceutical dosage form

Four torsemide-selective electrodes all on solid state graphite support were developed and characterized in polyvinylchloride matrices. Precipitation-based technique with tetraphenylborate (TPB) as an electroactive material in polyvinylchloride (PVC) matrix was used for sensor 1 fabrication without incorporation of an ionophore. 2hydroxypropyl- β-cyclodextrin (HP-β-CD) based technique with tetraphenylborate and either dioctyl phatalate (DOP), dibutyl sebasate (DBS) or 2-nitrophenyl octyl ether (o- NPOE) as plastisizer in carboxylated polyvinylchloride (PVC-COOH) matrix were used for sensor 2, 3 and 4 fabrications, respectively. Fast and stable Nernstian responses were evaluated according to IUPAC recommendations in the concentration ranges from 1 × 10-5 to 1 × 10-3 M for sensor 1 , from 1 × 10-5 to 1 × 10-2 M for sensor 2, from 1 × 10-6 to 1 × 10-4 M for sensor 3, and from 1 × 10-6 to 1 × 10-3 M for sensor 4. The sensors show good selectivity to the drug in presence of a variety of inorganic and organic interferents including acid degradation product of torsemide, related substances and pharmaceutical excipients. Validation of the method showed the suitability of the proposed electrodes for the use in the quality control assessment of the drug. Furthermore, statistical comparison between the results obtained by the proposed method and the official method of the drug was performed and no significant difference was found.