Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector

Detalhes bibliográficos
Autor(a) principal: Cervini,Priscila
Data de Publicação: 2008
Outros Autores: Cavalheiro,Éder Tadeu Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500005
Resumo: A bare graphite-polyurethane composite was evaluated as an amperometric flow injection detector in the determination of paracetamol (APAP) in pharmaceutical formulations. A linear analytical curve was observed in the 5.00 x 10-5 to 5.00 x 10-3 mol L-1 range with a minimum detectable net concentration of 18.9 µmol L-1 and 180 determinations h-1, after optimization of parameters such as the detection potential, sample loop volume, and carrier solution flow rate. Interference of ascorbic acid was observed, however, it was possible overcome the interference, reaching results that agreed with HPLC within 95% confidence level. These results showed that the graphite-polyurethane composite can be used as an amperometric detector for flow analysis in the determination of APAP.
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spelling Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detectorparacetamolgraphite-PU composite electrodeFIAA bare graphite-polyurethane composite was evaluated as an amperometric flow injection detector in the determination of paracetamol (APAP) in pharmaceutical formulations. A linear analytical curve was observed in the 5.00 x 10-5 to 5.00 x 10-3 mol L-1 range with a minimum detectable net concentration of 18.9 µmol L-1 and 180 determinations h-1, after optimization of parameters such as the detection potential, sample loop volume, and carrier solution flow rate. Interference of ascorbic acid was observed, however, it was possible overcome the interference, reaching results that agreed with HPLC within 95% confidence level. These results showed that the graphite-polyurethane composite can be used as an amperometric detector for flow analysis in the determination of APAP.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500005Journal of the Brazilian Chemical Society v.19 n.5 2008reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532008000500005info:eu-repo/semantics/openAccessCervini,PriscilaCavalheiro,Éder Tadeu Gomeseng2008-08-05T00:00:00Zoai:scielo:S0103-50532008000500005Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2008-08-05T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
title Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
spellingShingle Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
Cervini,Priscila
paracetamol
graphite-PU composite electrode
FIA
title_short Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
title_full Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
title_fullStr Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
title_full_unstemmed Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
title_sort Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector
author Cervini,Priscila
author_facet Cervini,Priscila
Cavalheiro,Éder Tadeu Gomes
author_role author
author2 Cavalheiro,Éder Tadeu Gomes
author2_role author
dc.contributor.author.fl_str_mv Cervini,Priscila
Cavalheiro,Éder Tadeu Gomes
dc.subject.por.fl_str_mv paracetamol
graphite-PU composite electrode
FIA
topic paracetamol
graphite-PU composite electrode
FIA
description A bare graphite-polyurethane composite was evaluated as an amperometric flow injection detector in the determination of paracetamol (APAP) in pharmaceutical formulations. A linear analytical curve was observed in the 5.00 x 10-5 to 5.00 x 10-3 mol L-1 range with a minimum detectable net concentration of 18.9 µmol L-1 and 180 determinations h-1, after optimization of parameters such as the detection potential, sample loop volume, and carrier solution flow rate. Interference of ascorbic acid was observed, however, it was possible overcome the interference, reaching results that agreed with HPLC within 95% confidence level. These results showed that the graphite-polyurethane composite can be used as an amperometric detector for flow analysis in the determination of APAP.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000500005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532008000500005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.19 n.5 2008
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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